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Anisotropic Reinforcement to Improve Post-Infarction LV Function

各向异性强化可改善梗塞后左心室功能

基本信息

批准号：
8403788
负责人：
JEFFREY W HOLMES
金额：
$ 17.87万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-01-01 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8403788
关键词：
Acute Address Adrenergic beta-Antagonists Affect American Angioplasty Angiotensin-Converting Enzyme Inhibitors Animal Model Animals Anisotropy Anterior Area Canis familiaris Cardiology Cicatrix Clinical Computer Simulation Coronary artery Data Deterioration Development Fibrinolytic Agents Goals Healed Health Heart Heart failure Hour Infarction Lead Left Left Ventricular Function Left Ventricular Remodeling Location Mechanics Mental Depression Methods Muscle Myocardial Infarction Myocardium Natural regeneration Patients Pattern Pharmaceutical Preparations Preparation Property Psychological reinforcement Pump Recurrence Risk Role Shapes Stents Testing Therapeutic Tissues Ventricular Ventricular Function Woman Work base blood pump clinical application experience follow-up healing heart dimension/size heart function improved innovation men novel older patient prevent research study

项目摘要

Over a million Americans experience a myocardial infarction (heart attack) each year. Following a heart attack, damaged heart muscle cannot regenerate; instead, it is gradually replaced by scar tissue over the course of several weeks. The loss of heart muscle reduces the ability of the heart to pump blood, and in many cases this triggers a gradual decline in heart function and alterations in heart size and shape (remodeling) that ultimately lead to heart failure. Although drugs such as angiotensin converting enzyme (ACE) inhibitors can help reduce post-infarction remodeling, the risk of developing heart failure after surviving a heart attack remains high. Because the mechanical properties of the scar tissue that forms after a heart attack are critical determinants of both heart function and the eventual transition to heart failure, several new therapies under development attempt to modify the mechanical properties of that scar in order to reduce left ventricular (LV) remodeling, improve pump function, or both. Recent computer modeling and experimental studies suggest that infarcts that are very stiff in one direction but relatively soft in others (mechanically anisotropic) should provide the best heart function. This proposal focuses on a novel method to create mechanical anisotropy by surgically reinforcing the infarct. Based on preliminary data showing that anisotropic reinforcement dramatically improves pump function immediately after a heart attack, this project will test the hypothesis that anisotropic reinforcement reduces LV remodeling and functional deterioration over the first 2 months folowing myocardial infarction in a large animal model. New computational modeling studies will also determine whether infarcts in different locations require diferent patterns of mechanical reinforcement to optimize LV function.

每年有超过一百万的美国人经历心肌梗塞（心脏病发作）。跟随一颗心