Anisotropic Reinforcement to Improve Post-Infarction LV Function
各向异性强化可改善梗塞后左心室功能
基本信息
- 批准号:8403788
- 负责人:
- 金额:$ 17.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-01-01 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAdrenergic beta-AntagonistsAffectAmericanAngioplastyAngiotensin-Converting Enzyme InhibitorsAnimal ModelAnimalsAnisotropyAnteriorAreaCanis familiarisCardiologyCicatrixClinicalComputer SimulationCoronary arteryDataDeteriorationDevelopmentFibrinolytic AgentsGoalsHealedHealthHeartHeart failureHourInfarctionLeadLeftLeft Ventricular FunctionLeft Ventricular RemodelingLocationMechanicsMental DepressionMethodsMuscleMyocardial InfarctionMyocardiumNatural regenerationPatientsPatternPharmaceutical PreparationsPreparationPropertyPsychological reinforcementPumpRecurrenceRiskRoleShapesStentsTestingTherapeuticTissuesVentricularVentricular FunctionWomanWorkbaseblood pumpclinical applicationexperiencefollow-uphealingheart dimension/sizeheart functionimprovedinnovationmennovelolder patientpreventresearch study
项目摘要
Over a million Americans experience a myocardial infarction (heart attack) each year. Following a heart
attack, damaged heart muscle cannot regenerate; instead, it is gradually replaced by scar tissue over
the course of several weeks. The loss of heart muscle reduces the ability of the heart to pump blood,
and in many cases this triggers a gradual decline in heart function and alterations in heart size and
shape (remodeling) that ultimately lead to heart failure. Although drugs such as angiotensin converting
enzyme (ACE) inhibitors can help reduce post-infarction remodeling, the risk of developing heart failure
after surviving a heart attack remains high. Because the mechanical properties of the scar tissue that
forms after a heart attack are critical determinants of both heart function and the eventual transition to
heart failure, several new therapies under development attempt to modify the mechanical properties of
that scar in order to reduce left ventricular (LV) remodeling, improve pump function, or both. Recent
computer modeling and experimental studies suggest that infarcts that are very stiff in one direction but
relatively soft in others (mechanically anisotropic) should provide the best heart function. This proposal
focuses on a novel method to create mechanical anisotropy by surgically reinforcing the infarct. Based
on preliminary data showing that anisotropic reinforcement dramatically improves pump function
immediately after a heart attack, this project will test the hypothesis that anisotropic reinforcement
reduces LV remodeling and functional deterioration over the first 2 months folowing myocardial
infarction in a large animal model. New computational modeling studies will also determine whether
infarcts in different locations require diferent patterns of mechanical reinforcement to optimize LV
function.
每年有超过一百万美国人经历心肌梗塞(心脏病发作)。追随一颗心
发作时,受损的心肌无法再生;相反,它逐渐被疤痕组织取代
持续数周的过程。心肌的损失会降低心脏泵血的能力,
在许多情况下,这会引发心脏功能逐渐下降以及心脏大小和形状的改变
最终导致心力衰竭的形状(重塑)。虽然血管紧张素转换酶等药物
酶(ACE)抑制剂可以帮助减少梗死后重构,即发生心力衰竭的风险
心脏病发作后幸存下来仍然很高。因为疤痕组织的机械特性
心脏病发作后的形态是心脏功能和最终过渡到心脏功能的关键决定因素
心力衰竭,几种正在开发的新疗法试图改变心力衰竭的机械性能
去除疤痕是为了减少左心室 (LV) 重塑、改善泵功能,或两者兼而有之。最近的
计算机建模和实验研究表明,梗塞在一个方向上非常僵硬,但
其他相对较软(机械各向异性)应提供最佳的心脏功能。这个提议
专注于一种通过手术强化梗塞来产生机械各向异性的新方法。基于
初步数据显示,各向异性加固可显着改善泵功能
心脏病发作后,该项目将立即测试各向异性强化的假设
减少心肌梗塞后头 2 个月内的左室重塑和功能恶化
大型动物模型中的梗死。新的计算模型研究还将确定是否
不同位置的梗塞需要不同的机械强化模式来优化左心室
功能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JEFFREY W HOLMES其他文献
JEFFREY W HOLMES的其他文献
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{{ truncateString('JEFFREY W HOLMES', 18)}}的其他基金
Systems Pharmacology Model for Spatial Control of Cardiac Fibrosis
心脏纤维化空间控制的系统药理学模型
- 批准号:
9363220 - 财政年份:2017
- 资助金额:
$ 17.87万 - 项目类别:
2017 Summer Biomechanics, Bioengineering and Biotransport Conference
2017夏季生物力学、生物工程与生物转运会议
- 批准号:
9330598 - 财政年份:2017
- 资助金额:
$ 17.87万 - 项目类别:
Multiscale Models of Cardiac Growth, Remodeling, and Myocardial Infarction
心脏生长、重塑和心肌梗死的多尺度模型
- 批准号:
9144435 - 财政年份:2015
- 资助金额:
$ 17.87万 - 项目类别:
Computational Modeling of Scar Formation After Myocardial Infarction
心肌梗塞后疤痕形成的计算模型
- 批准号:
8916817 - 财政年份:2014
- 资助金额:
$ 17.87万 - 项目类别:
Computational Modeling of Scar Formation After Myocardial Infarction
心肌梗塞后疤痕形成的计算模型
- 批准号:
9131778 - 财政年份:2014
- 资助金额:
$ 17.87万 - 项目类别:
Computational Modeling of Scar Formation After Myocardial Infarction
心肌梗塞后疤痕形成的计算模型
- 批准号:
8629133 - 财政年份:2014
- 资助金额:
$ 17.87万 - 项目类别:
Anisotropic Reinforcement to Improve Post-Infarction LV Function
各向异性强化可改善梗塞后左心室功能
- 批准号:
8223807 - 财政年份:2012
- 资助金额:
$ 17.87万 - 项目类别:
PARAMETERIZATION OF CARDIAC WALL MOTION: REUNITING ENGINEERING & CARDIOLOGY
心壁运动的参数化:重新结合工程
- 批准号:
8169343 - 财政年份:2010
- 资助金额:
$ 17.87万 - 项目类别:
PARAMETERIZATION OF CARDIAC WALL MOTION: REUNITING ENGINEERING & CARDIOLOGY
心壁运动的参数化:重新结合工程
- 批准号:
7955232 - 财政年份:2009
- 资助金额:
$ 17.87万 - 项目类别:
MODEL-BASED DEVELOPMENT OF NEW DIAGNOSTIC MEASURES
基于模型的新诊断措施开发
- 批准号:
7955292 - 财政年份:2009
- 资助金额:
$ 17.87万 - 项目类别:
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