树突状细胞激活在肝纤维化发病机制中的作用-猫眼课题宝

树突状细胞激活在肝纤维化发病机制中的作用

批准号：

8673488

负责人：

George Miller

金额：

$14.86万

依托单位：

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-01-21 至 2016-01-20

来源：

https://reporter.nih.gov/project-details/8673488

关键词：

Accounting Affect Antigen-Presenting Cells Antigens CCL11 gene CCL2 gene CCL22 gene CCL23 gene Cell Culture Techniques Cell physiology Complex Dendritic Cells Dendritic cell activation Deposition Development Dose Effector Cell Extracellular Matrix Fibrosis Grant Hepatic Hepatic Stellate Cell Immune Immune Tolerance Immune response Immunity Immunosuppression In Vitro Inflammation Mediators Inflammatory Injury to Liver Interleukin-13 Interleukin-4 Interleukin-5 Interleukin-6 Liver Liver Cirrhosis Liver Fibrosis Liver parenchyma Lymphoid Tissue Macrophage Inflammatory Protein-1 Mediator of activation protein Molecular Mus Natural Killer Cells Nodal Organ Pathogenesis Phenotype Process Public Health Role Solid Staging T cell anergy T-Lymphocyte TNF gene Therapeutic Toxin Virus Work cell type chemokine cytokine cytotoxic immunogenic immunogenicity in vivo liver function liver injury liver transplantation research study response

项目摘要

项目成果

George Miller的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

Specific aims of this study are (i) To determine whether liver DC convert from inert inducers of tolerance to potent immune-stimulators and mediators of inflammation in liver fibrosis, (ii) To determine the contributory role of DC in the pathogenesis of fibrosis and their direct role in HSC activation, (iii) To determine whether blockade of the immunogenic function of liver DC can mitigate the fibrogenic response to liver injury. In vitro and in vivo experiments in Aims 2 and 3 were affected by our loss of cell cultures, mice, and our lab shutdown and then relocation. An extension will help us complete the Aims of the grant which has been very fruitful till this point.

期刊论文(2)

专著(0)

科研奖励(0)

会议论文

Interleukin 17-producing γδT cells promote hepatic regeneration in mice.

产生白细胞介素 17 的 γδT 细胞促进小鼠肝脏再生。

DOI： 10.1053/j.gastro.2014.04.042

发表时间： 2014-08

期刊：

Gastroenterology

影响因子： 29.4

作者：

[Rao R, Graffeo CS, Gulati R, Jamal M, Narayan S, Zambirinis CP, Barilla R, Deutsch M, Greco SH, Ochi A, Tomkötter L, Blobstein R, Avanzi A, Tippens DM, Gelbstein Y, Van Heerden E, Miller G]

通讯作者： Miller G

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

DOI： 10.1016/j.ccell.2018.10.006

发表时间： 2018-11-12

期刊：

Cancer cell

影响因子： 50.3

作者：

[Wang W, Marinis JM, Beal AM, Savadkar S, Wu Y, Khan M, Taunk PS, Wu N, Su W, Wu J, Ahsan A, Kurz E, Chen T, Yaboh I, Li F, Gutierrez J, Diskin B, Hundeyin M, Reilly M, Lich JD, Harris PA, Mahajan MK, Thorpe JH, Nassau P, Mosley JE, Leinwand J, Kochen Rossi JA, Mishra A, Aykut B, Glacken M, Ochi A, Verma N, Kim JI, Vasudevaraja V, Adeegbe D, Almonte C, Bagdatlioglu E, Cohen DJ, Wong KK, Bertin J, Miller G]

通讯作者： Miller G