Research Training for Physician-Scientists in Gastrointestinal Oncology

 描述(由申请人提供)：此申请寻求建立一个新的NIH资助的T32计划，以培训下一代胃肠道肿瘤学的内科科学家。我们认为，经过严格研究培训的内科科学家对于发现和转化胃肠道肿瘤学的新进展以及调查向患者提供癌症护理所面临的关键问题是必要的。我们的实习生将从纽约大学著名的内科肿瘤学或胃肠病学临床奖学金项目或放射肿瘤学或外科顶级住院医师项目中挑选出来。从代表不足的少数群体中招募个人将是至关重要的。受训人员将从临床活动中抽出两年时间，参加有关胃肠道癌症研究的全日制强化培训。我们建议的计划将有两个不同的轨道：(I)基础/转化科学轨道，面向希望指导自己的胃肠道肿瘤学基础科学实验室的个人，或希望领导在临床前实验室和临床调查之间轻松对接的转化性研究计划的个人；(Ii)人口科学轨道，面向寻求作为尖端GI癌症临床试验人员或在人口科学的不同领域，如癌症流行病学、比较有效性、差异或结果研究的受训者。这两个轨道将通过每周2小时的核心课程统一起来，涵盖GI癌症的基本主题和为癌症医生开始独立调查职业生涯的关键课程。我们的基础/转化科学轨道的特定轨道计划将包括两年的个性化指导研究，在学院实验室进行，并通过癌症生物学的强大平行教学计划来加强。人口科学课程将以严格的硕士课程为中心，教授临床试验设计、流行病学、比较有效性和结果研究方法，以及基于人口科学的指导性研究项目。因此，医学实习生将在基础或转化性胃肠道肿瘤学或人口科学方面进行密集培训，从而获得领导基础或转化性实验室、领导创新临床试验和/或开发人口科学计划所需的技能。我们计划每年招收3名博士后候选人，稳定在任何时候招收6名实习生。我们的计划将由一批在癌症研究和培训记录方面取得重大成就和无可挑剔的声誉的导师领导。该计划将得到纽约大学丰富的多学科胃肠道癌症计划的支持，该计划是一个重要的机构力量，目前拥有约35项胃肠道肿瘤临床试验。该奖学金的目标将是培养拥有领导自己研究计划的能力和资历的毕业内科科学家，并最终成为调查胃肠道肿瘤学的领导者和榜样。我们希望我们所有的毕业生都将完成他们的培训，并配备完善的K-Level助学金，以实现他们的第一次学术任命，我们预计该项目将成为培训胃肠道癌症研究方面的医生和研究人员的典范。

 DESCRIPTION (provided by applicant): This application seeks to establish a new NIH-funded T32 program to train the next generation of physician- scientists in gastrointestinal oncology. We believe that physician-scientists armed with rigorous research training are necessary to discover and translate new advances in gastrointestinal oncology as well as to investigate critical issues facing delivery of cancer care to patients. Our trainees will be drawn from NYU's renowned clinical fellowship programs in Medical Oncology or Gastroenterology or top-notch residency programs in Radiation Oncology or Surgery. Recruiting individuals from underrepresented minority groups will be paramount. Trainees will take a 2 year hiatus from clinical activities to engage in intensive full-time training in GI cancer research. Our proposed program will have 2 distinct tracks: (i) a Basic/Translational Science track aimed at individuals who wish to direct their own basic science laboratory in GI oncology or individuals who want to lead translational research programs that comfortably interface between the pre-clinical laboratory and clinical investigation and (ii) a Population Sciences tract for trainees who seek careers as cutting edge GI cancer clinical trialists or in the diverse fields of population science such as cancer epidemiology, comparative effectiveness, disparities, or outcomes research. The two tracks will be united through a weekly 2-hour core curriculum covering essential topics in GI cancer and critical lessons for cancer physicians embarking on independent investigative careers. The track-specific program for our Basic/Translational Science track will consist of two years of individualized mentored research in faculty laboratories, enhanced by a strong parallel didactic program in cancer biology. The Population Sciences track will be centered on a rigorous Masters-level curriculum that teaches clinical trial design, epidemiology, comparative-effectiveness, and outcomes research methodologies along with a mentored research project based in population sciences. Thus, physician-trainees will train intensively in basic or translational GI oncology or population sciences and thereby acquire the necessary skills to head a basic or translational laboratory, lead innovative clinical trials, and/or develop a population science program. We plan to enroll 3 new post-doctoral candidates annualy for a steady-state of 6 trainees at any given time. Our program will be led by a cadre of mentors with significant accomplishments and impeccable reputations in cancer research and stellar training records. The program will be supported by the rich Multidisciplinary GI Cancer Program at NYU which is a significant institutional strength that currently houses ~35 clinical trials in GI oncolgy. The aim of the fellowship will be to graduate physician-scientists armed with the capacity and credentials to lead their own research programs and eventually become leaders and role models in investigative GI oncology. We expect that all our graduates will finish their training armed with well-developed K-level grants to bring to their first academic appointment and we expect this program will become the paradigm for training physician-investigators in GI cancer research.