Research Training for Physician-Scientists in Gastrointestinal Oncology

 描述（由申请人提供）：本申请旨在建立一个新的NIH资助的T32项目，以培养下一代胃肠道肿瘤学的医生-科学家。我们认为，有严格的研究训练武装的医生科学家是必要的，以发现和翻译在胃肠道肿瘤学的新进展，以及调查面临的关键问题提供癌症护理的病人。我们的学员将来自纽约大学著名的临床肿瘤学或胃肠病学奖学金计划或放射肿瘤学或外科的一流住院医师计划。从代表性不足的少数群体中征聘个人将是至关重要的。受训者将从临床活动中抽出2年时间，从事GI癌症研究的强化全日制培训。我们的计划将有两个不同的轨道：（i）基础/转化科学轨道，针对希望在GI肿瘤学中指导自己的基础科学实验室的个人或希望领导转化研究项目的个人，这些项目在临床前实验室和临床研究之间提供了良好的接口，以及（ii）一个人口科学领域的学员谁寻求职业生涯作为尖端胃肠道癌症临床试验或在人口科学的不同领域，如癌症流行病学，比较有效性，差距，或成果研究。这两个轨道将通过每周2小时的核心课程，涵盖在胃肠道癌症和癌症医生开始独立的调查职业生涯的关键教训的基本主题相结合。我们的基础/转化科学轨道的轨道特定程序将包括两年的个性化指导研究在教师实验室，通过癌症生物学强有力的平行教学计划增强。人口科学轨道将集中在一个严格的硕士水平的课程，教授临床试验设计，流行病学，比较有效性和结果的研究方法沿着与指导的研究项目为基础的人口科学。因此，实习医生将在基础或转化胃肠道肿瘤学或人口科学方面进行密集培训，从而获得必要的技能，领导基础或转化实验室，领导创新的临床试验和/或开发人口科学计划。我们计划每年招收3名新的博士后候选人，以确保在任何给定时间都有6名实习生。我们的计划将由一批在癌症研究和一流培训记录方面取得重大成就和无可挑剔声誉的导师领导。该计划将得到纽约大学丰富的多学科GI癌症计划的支持，该计划是一个重要的机构力量，目前拥有约35项GI肿瘤学临床试验。该奖学金的目的将是毕业的医生科学家武装的能力和证书，以领导自己的研究计划，并最终成为领导者和榜样，在调查胃肠道肿瘤学。我们希望我们所有的毕业生将完成他们的培训武装与发达的K级赠款，使他们的第一次学术任命，我们希望这个计划将成为培训医生，调查人员在胃肠道癌症研究的典范。

 DESCRIPTION (provided by applicant): This application seeks to establish a new NIH-funded T32 program to train the next generation of physician- scientists in gastrointestinal oncology. We believe that physician-scientists armed with rigorous research training are necessary to discover and translate new advances in gastrointestinal oncology as well as to investigate critical issues facing delivery of cancer care to patients. Our trainees will be drawn from NYU's renowned clinical fellowship programs in Medical Oncology or Gastroenterology or top-notch residency programs in Radiation Oncology or Surgery. Recruiting individuals from underrepresented minority groups will be paramount. Trainees will take a 2 year hiatus from clinical activities to engage in intensive full-time training in GI cancer research. Our proposed program will have 2 distinct tracks: (i) a Basic/Translational Science track aimed at individuals who wish to direct their own basic science laboratory in GI oncology or individuals who want to lead translational research programs that comfortably interface between the pre-clinical laboratory and clinical investigation and (ii) a Population Sciences tract for trainees who seek careers as cutting edge GI cancer clinical trialists or in the diverse fields of population science such as cancer epidemiology, comparative effectiveness, disparities, or outcomes research. The two tracks will be united through a weekly 2-hour core curriculum covering essential topics in GI cancer and critical lessons for cancer physicians embarking on independent investigative careers. The track-specific program for our Basic/Translational Science track will consist of two years of individualized mentored research in faculty laboratories, enhanced by a strong parallel didactic program in cancer biology. The Population Sciences track will be centered on a rigorous Masters-level curriculum that teaches clinical trial design, epidemiology, comparative-effectiveness, and outcomes research methodologies along with a mentored research project based in population sciences. Thus, physician-trainees will train intensively in basic or translational GI oncology or population sciences and thereby acquire the necessary skills to head a basic or translational laboratory, lead innovative clinical trials, and/or develop a population science program. We plan to enroll 3 new post-doctoral candidates annualy for a steady-state of 6 trainees at any given time. Our program will be led by a cadre of mentors with significant accomplishments and impeccable reputations in cancer research and stellar training records. The program will be supported by the rich Multidisciplinary GI Cancer Program at NYU which is a significant institutional strength that currently houses ~35 clinical trials in GI oncolgy. The aim of the fellowship will be to graduate physician-scientists armed with the capacity and credentials to lead their own research programs and eventually become leaders and role models in investigative GI oncology. We expect that all our graduates will finish their training armed with well-developed K-level grants to bring to their first academic appointment and we expect this program will become the paradigm for training physician-investigators in GI cancer research.