FASEB SRC on post-transcriptional control of gene expression: Mechanisms of mRNA
FASEB SRC 关于基因表达转录后控制:mRNA 机制
基本信息
- 批准号:8720301
- 负责人:
- 金额:$ 0.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-05-01 至 2015-04-30
- 项目状态:已结题
- 来源:
- 关键词:BackBacteriaBiologyBiomedical ResearchCollaborationsCommunicable DiseasesDefectEnvironmentEnzymesEukaryotaEvaluationFertilizationFundingGene ExpressionGenetic TranscriptionGoalsHealthHereditary DiseaseHuman GeneticsLeftLettersMessenger RNAMontanaMutationOrganismPaperParticipantPlantsPost-Transcriptional RegulationPostdoctoral FellowProkaryotic CellsProtein BiosynthesisRNARNA DegradationRNA InterferenceRegulationResearchResearch PersonnelScheduleScientistSeriesSiteSystemabstractingdesigndisease-causing mutationexpectationgraduate studentmRNA DecaymRNA Transcript Degradationmeetingspathogenpublic health relevancesuccesssymposiumtool
项目摘要
DESCRIPTION (provided by applicant): The understanding that mRNA degradation is critical for gene expression traces back to 1959 when Pardee Jacob and Monod demonstrated in a historical paper that there had to be an unstable intermediate directing protein synthesis. More recently, the spectacular use of RNAi to experimentally degrade specific mRNAs has expanded the applications of understanding mRNA decay mechanisms beyond any expectations. Thus, mRNA degradation is clearly of fundamental importance to gene expression, and a complete understanding of mRNA degradation mechanisms and its regulation has clear applications for understanding biomedical problems and for generating new tools for biomedical research. The FASEB meeting on mechanisms of mRNA decay has developed into a unique conference that brings together the leading experts in mRNA decay in metazoan, fungal, plant, bacterial, and archaeal systems. Although we have a thorough understanding of how transcription and its regulation contribute to gene expression, our understanding of post-transcriptional steps in gene expression is incomplete. Almost every iteration of this FASEB meeting has included revelations of new enzymes involved in mRNA decay, and more may remain to be discovered for the 2014 meeting. For example, at the last meeting in 2012 the first results that indicated that DIS3L2 was involved in mRNA decay were discussed. Thus, much remains to be discovered about the mechanism of mRNA degradation, and a complete understanding of the mechanism is an obvious pre-requisite to understanding regulation. Towards the broad and long-term goal of increasing our understanding of the mechanisms of mRNA degradation we are continuing a series of scientific meetings from July 6th to 11th 2014 in Big Sky, Montana. The 2014 meeting is the 9th in a series organized by FASEB, which followed similar meetings organized by ASM in the 90's. This series of meetings has had a major impact on the field and is exceptionally valued as evidenced by the fact that 96% of the attendees of the 2012 meeting indicated that they planned to attend the 2014 meeting on the evaluation form, that only 1 of the 36 invited speakers declined our invitation for the 2014 meeting, and by the enclosed support letters of session chairs for the upcoming meeting. We hope to achieve this goal through three specific aims
描述(由申请人提供):mRNA降解对基因表达至关重要的认识可追溯到1959年,当时Pardee Jacob和Monod在一篇历史论文中证明,必须有一种不稳定的中间体指导蛋白质合成。最近,RNAi在实验上降解特定mRNA的惊人应用超出了任何预期,扩大了理解mRNA衰变机制的应用。因此,mRNA降解显然是基因表达的根本重要性,mRNA降解机制及其调节的完整理解有明确的应用程序,了解生物医学问题和生物医学研究的新工具。关于mRNA衰变机制的FASEB会议已经发展成为一个独特的会议,汇集了后生动物,真菌,植物,细菌和古细菌系统中mRNA衰变的领先专家。 虽然我们对转录及其调控如何促进基因表达有了透彻的理解,但我们对基因表达中转录后步骤的理解是不完整的。几乎每一次FASEB会议的迭代都包含了与mRNA衰变有关的新酶的发现,2014年的会议可能还会发现更多。例如,在2012年的最后一次会议上,讨论了表明DIS3L2参与mRNA衰变的第一个结果。因此,关于mRNA降解的机制仍有许多有待发现,而对该机制的完整理解是理解调控的明显先决条件。 为了提高我们对mRNA降解机制的理解这一广泛而长期的目标,我们将于2014年7月6日至11日在蒙大拿州的大天空继续举行一系列科学会议。2014年的会议是FASEB组织的系列会议中的第9次,该系列会议是ASM在90年代组织的类似会议之后举办的。这一系列会议对该领域产生了重大影响,并受到特别重视,2012年会议的与会者中有96%表示他们计划参加2014年会议的评估表,36位受邀发言人中只有一位拒绝了我们2014年会议的邀请,以及所附的会议主席关于即将举行的会议的支持信。我们希望通过三个具体目标来实现这一目标
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AMBRO VAN HOOF其他文献
AMBRO VAN HOOF的其他文献
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{{ truncateString('AMBRO VAN HOOF', 18)}}的其他基金
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10612205 - 财政年份:2022
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$ 0.9万 - 项目类别:
RNAse functions in post-transcriptional gene regulation
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RNAse 在转录后基因调控中发挥作用
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10601070 - 财政年份:2021
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RNAse functions in post-transcriptional gene regulation
RNAse 在转录后基因调控中发挥作用
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10203253 - 财政年份:2021
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RNA decay and processing activities of the RNA exosome
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8464162 - 财政年份:2012
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RNA decay and processing activities of the RNA exosome
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