CAI2R Technology Research and Development Project #1: Towards Rapid Continuous Comprehensive MR Imaging: New Methods, New Paradigms, and New Applications

项目概要：技术研发项目#1 快速连续综合磁共振成像：新方法、新范例和新应用 TR&D #1首席研究员： Ricardo Otazo博士和丹尼尔K. Sodickson，医学博士，博士 我们的先进成像创新与研究中心（CAI2R）的广泛使命是汇集 合作转化研究团队，用于开发高影响力的生物医学成像技术， 最终目标是改变日常的临床实践。技术研究与开发（TR&D） 项目#1的目标是在成像中使用新的时间，部署快速图像采集的前沿方法， 先进的图像重建，以取代传统的复杂，有针对性和效率低下的成像协议， 简单、全面、体积采集，包含有关多个互补 对比和多样的动态。具体目标如下： (1)新方法：开发新的快速MR采集和重建策略，专门针对 合作和服务项目的需求，利用压缩传感，并行成像和 基于模型的重建 (2)新范例：使用连续更新的运动鲁棒性，建立MR扫描的新范例 全面的采集消除了死区时间，再加上用户定制的图像重建， 定义的对比度和时空轮廓。 (3)新的应用：在协作和服务项目中实施这种新的扫描模式，并评估 其在常规患者人群中的有效性，用于高容量高影响临床应用。

Project Summary: Technology Research and Development Project #1 Towards Rapid Continuous Comprehensive MR Imaging: New Methods, New Paradigms, and New Applications TR&D #1 Principal Investigators: Ricardo Otazo, PhD and Daniel K. Sodickson, MD, PhD The broad mission of our Center for Advanced Imaging Innovation and Research (CAI2R) is to bring together collaborative translational research teams for the development of high-impact biomedical imaging technologies, with the ultimate goal of changing day-to-day clinical practice. Technology Research and Development (TR&D) project #1 aims at a new use of time in imaging, deploying leading-edge methods of rapid image acquisition and advanced image reconstruction to replace traditional complex, targeted, and inefficient imaging protocols with simple, comprehensive, volumetric acquisitions that contain rich information about multiple complementary contrasts and diverse dynamics. Specific aims are as follows: (1) New methods: Develop novel rapid MR acquisition and reconstruction strategies specifically tailored to the needs of collaborative and service projects, taking advantage of compressed sensing, parallel imaging and model-based reconstruction. (2) New paradigm: Establish a new paradigm for MR scanning, using continuously-updated motion-robust comprehensive acquisitions eliminating dead time, coupled with tailored image reconstructions with user- defined contrast and spatiotemporal profiles. (3) New applications: Implement this new scanning paradigm in collaborative and service projects and evaluate its efficacy in routine patient populations for high-volume high-impact clinical applications.