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Novel Adipokines and Coronary Heart Disease in U.S. Men and Women with Diabetes

美国男性和女性糖尿病患者中的新型脂肪因子和冠心病

基本信息

批准号：
8669052
负责人：
Qi Sun
金额：
$ 24.36万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8669052
关键词：
Accounting Address Adipocytes Adipose tissue Alcohol consumption Animals Area Atherosclerosis Award Basic Science Biochemical Biological Assay Biological Markers Blood specimen Body Weight Body mass index Cardiovascular Diseases Case-Control Studies Cause of Death Cessation of life Clinical Clinical Medicine Cohort Studies Collection Communities Complication Coronary heart disease Data Development Diabetes Mellitus Dietary Factors Disease Disease Association Dyslipidemias Early Diagnosis Environment Environmental Risk Factor Epidemiologic Studies Epidemiology Etiology FABP4 gene Fatty acid glycerol esters Female Functional disorder Funding General Population Genetic Genetic Determinism Genome Goals Grant Health Professional Housing Human Hypertension Individual Inflammation Insulin Resistance K-Series Research Career Programs Knowledge Linkage Disequilibrium Measures Medical Mentored Clinical Scientist Development Award (K08)Mentors Methods Mission Molecular Epidemiology Molecular Genetics Molecular Weight National Heart, Lung, and Blood Institute Non-Insulin-Dependent Diabetes Mellitus Nurses&apos Health Study Outcome Pathway interactions Phase Physical activity Plasma Play Population Prevention Prevention strategy Preventive Medicine Public Health Schools Qi Randomized Regulation Research Research Activity Research Design Research Personnel Retinol Binding Proteins Risk Risk Factors Role Sampling Scientist Single Nucleotide Polymorphism Stroke Testing The Sun Training Training Activity Translating Translations Visceral Woman Work abstracting adipokines adiponectin atherogenesis base cardiovascular disorder risk cardiovascular risk factor career career development clinical practice cohort diabetic diabetic patient epidemiologic data experience follow-up gene environment interaction genetic analysis genetic epidemiology genetic risk factor genetic variant genome wide association study glycemic control heart disease prevention heart disease risk high risk human FABP4 protein human data indexing inflammatory marker interdisciplinary approach interest lifestyle factors men novel novel marker prospective skills symposium therapeutic target treatment strategy waist circumference

项目摘要

6. Project Summary/Abstract There is an urgent need to identify and examine novel risk factors that can be utilized in the prevention and treatment of cardiovascular disease (CVD). Dr. Qi Sun has developed a strong interest in identifying novel biomedical and genetic risk factors for CVD and dedicated himself to a career in genetic and molecular epidemiology of CVD. To gain knowledge and skills necessary for the transition into an independent researcher in this field, Dr. Sun will implement a comprehensive training plan encompassing advanced course work in genetic epidemiology, attendance at seminars and research conferences, close interactions with mentors, and other significant research activities in the mentored K99 phase of this career development award. Drs. Frank Hu and James Meigs, two well-established researchers and highly experienced trainers, will serve as the mentors. The Harvard School of Public Health will provide an ideal environment for Dr. Sun's training and career development. The Harvard medical community houses a rich collection of established investigators with expertise in various areas who will provide additional training to Dr. Sun. The training activities will focus on acquiring knowledge and skills in genetic epidemiology, as well as expertise on epidemiologic study design and statistical analysis of genetic data. This training is necessary and essential for Dr. Sun's development into an independent scientist capable of using interdisciplinary approaches to addressing research questions in molecular and genetic CVD epidemiology. During the R00 phase of this award, Dr. Sun proposes to assay and examine three novel adipokines, i.e., retinol binding protein 4, fatty acid binding protein 4, and high-molecular-weight adiponectin, in plasma in relation to coronary heart disease (CHD) among type 2 diabetic patients in two large prospective cohorts. In addition, Dr. Sun will conduct whole-genome association (GWA) studies to search for genetic determinants for these biomarkers and subsequently utilize identified genetic variants to corroborate biomarker-disease associations and to examine gene-environment interactions. These biomarkers are identified in animal studies and proven to play causal roles in the etiology of CHD. However, lack of prospective human data limits the use of these molecules in the treatment and prevention of CHD in humans. The genetic studies will greatly deepen the understanding of genetic regulation on these molecules and facilitate the identification of high-risk populations. The proposed studies will provide timely and critical data that can be directly translated into CHD prevention and treatment strategies and, thus, are highly relevant to the mission of NHLBI.

6.项目总结/摘要迫切需要确定和审查新的风险因素，可用于预防和治疗心血管疾病（CVD）。孙奇博士对鉴定新的生物医学和遗传风险因素的心血管疾病，并致力于职业生涯中的遗传和分子 CVD的流行病学。获得必要的知识和技能过渡到一个独立的作为这一领域的研究人员，孙博士将实施一个全面的培训计划，包括高级课程从事遗传流行病学工作，出席研讨会和研究会议，与导师，和其他重要的研究活动，在辅导K99阶段的职业发展奖。 Drs. Frank Hu和James Meigs，两位知名的研究人员和经验丰富的培训师，将担任作为导师。哈佛公共卫生学院将为孙博士的培训提供理想的环境和职业发展。哈佛医学界聚集了一批经验丰富的研究人员他们将为孙博士提供额外的培训。培训活动将侧重于获得遗传流行病学的知识和技能，以及流行病学研究设计的专业知识和遗传数据的统计分析。这种训练是必要的和必不可少的孙博士的发展，一个独立的科学家能够使用跨学科的方法来解决研究问题，分子和遗传CVD流行病学。在该奖项的R 00阶段，孙博士建议分析和检查三种新的脂肪因子，即，视黄醇结合蛋白4、脂肪酸结合蛋白4和高分子量脂联素，在两个大型前瞻性队列中，2型糖尿病患者与冠心病（CHD）的关系。在此外，孙博士将进行全基因组关联（GWA）研究，以寻找遗传决定因素，这些生物标志物并随后利用鉴定的遗传变异来证实生物标志物疾病研究基因与环境的相互作用。这些生物标志物是在动物研究中确定的并被证明在冠心病的病因学中起着因果作用。然而，由于缺乏前瞻性的人类数据，这些分子在治疗和预防人类CHD中的应用。基因研究将大大深化了解这些分子的遗传调控，并促进高风险的识别人口。拟议的研究将提供可直接转化为CHD的及时和关键数据预防和治疗策略，因此，与国家HLBI的使命高度相关。