Novel Adipokines and Coronary Heart Disease in U.S. Men and Women with Diabetes

6.项目摘要/摘要 迫切需要确定和审查可用于预防和控制艾滋病的新的风险因素 治疗心血管疾病(CVD)。孙奇博士对小说的鉴赏产生了浓厚的兴趣 CVD的生物医学和遗传风险因素，致力于遗传和分子方面的职业 心血管疾病的流行病学。获得向独立企业转型所需的知识和技能 作为这一领域的研究人员，孙先生将实施包括高级课程在内的全面培训计划 在遗传流行病学方面的工作，出席研讨会和研究会议，与 导师，和其他重要的研究活动的导师K99阶段的这一职业发展奖。 Frank Hu博士和James Meigs博士是两位久负盛名的研究人员和经验丰富的培训师，他们将担任 作为导师。哈佛公共卫生学院将为孙博士的培训提供理想的环境 和职业发展。哈佛医学界聚集了一大批成熟的研究人员。 拥有多个领域的专业知识，将为孙先生提供额外的培训。培训活动将重点放在 获取遗传流行病学的知识和技能，以及流行病学研究设计方面的专门知识 以及遗传数据的统计分析。这种培训对于孙中山先生的发展是必要的和必不可少的 一位能够使用跨学科方法解决研究问题的独立科学家 分子和遗传心血管疾病流行病学。 在该奖项的R00阶段，孙博士建议化验和检测三种新的脂肪因子，即， 血浆中视黄醇结合蛋白4、脂肪酸结合蛋白4和高分子脂联素 在两个大型前瞻性队列中，2型糖尿病患者与冠心病的关系。在……里面 此外，孙博士将进行全基因组关联(GWA)研究，以寻找 这些生物标记物随后利用已识别的遗传变异来证实生物标记物疾病 并研究基因与环境之间的相互作用。这些生物标记物是在动物研究中确定的。 并被证实在冠心病的病因中起因果作用。然而，缺乏预期的人类数据限制了这一用途 这些分子在治疗和预防人类冠心病方面的作用。遗传学研究将大大深化 了解这些分子的遗传调控并有助于识别高危 人口。拟议的研究将提供可直接转化为冠心病的及时和关键的数据 预防和治疗战略，因此，与NHLBI的使命高度相关。

6. Project Summary/Abstract There is an urgent need to identify and examine novel risk factors that can be utilized in the prevention and treatment of cardiovascular disease (CVD). Dr. Qi Sun has developed a strong interest in identifying novel biomedical and genetic risk factors for CVD and dedicated himself to a career in genetic and molecular epidemiology of CVD. To gain knowledge and skills necessary for the transition into an independent researcher in this field, Dr. Sun will implement a comprehensive training plan encompassing advanced course work in genetic epidemiology, attendance at seminars and research conferences, close interactions with mentors, and other significant research activities in the mentored K99 phase of this career development award. Drs. Frank Hu and James Meigs, two well-established researchers and highly experienced trainers, will serve as the mentors. The Harvard School of Public Health will provide an ideal environment for Dr. Sun's training and career development. The Harvard medical community houses a rich collection of established investigators with expertise in various areas who will provide additional training to Dr. Sun. The training activities will focus on acquiring knowledge and skills in genetic epidemiology, as well as expertise on epidemiologic study design and statistical analysis of genetic data. This training is necessary and essential for Dr. Sun's development into an independent scientist capable of using interdisciplinary approaches to addressing research questions in molecular and genetic CVD epidemiology. During the R00 phase of this award, Dr. Sun proposes to assay and examine three novel adipokines, i.e., retinol binding protein 4, fatty acid binding protein 4, and high-molecular-weight adiponectin, in plasma in relation to coronary heart disease (CHD) among type 2 diabetic patients in two large prospective cohorts. In addition, Dr. Sun will conduct whole-genome association (GWA) studies to search for genetic determinants for these biomarkers and subsequently utilize identified genetic variants to corroborate biomarker-disease associations and to examine gene-environment interactions. These biomarkers are identified in animal studies and proven to play causal roles in the etiology of CHD. However, lack of prospective human data limits the use of these molecules in the treatment and prevention of CHD in humans. The genetic studies will greatly deepen the understanding of genetic regulation on these molecules and facilitate the identification of high-risk populations. The proposed studies will provide timely and critical data that can be directly translated into CHD prevention and treatment strategies and, thus, are highly relevant to the mission of NHLBI.