Interdisciplinary and Translational Research Training in NeuroAIDS

描述（由申请人提供）：这份修订后的竞争性续期申请为研究HIV感染中枢神经系统并发症和相关研究领域的博士生提供了“神经艾滋病跨学科和转化研究培训计划（ITRTP）”的延续和进一步发展的计划。这是天普大学（Temple University）和德雷塞尔大学（Drexel University）两所院校的联合项目，位于宾夕法尼亚州费城附近。该项目还整合了包括坦普尔大学和德雷塞尔大学在内的神经艾滋病综合中心（CNAC）的培训活动和研究资源，以及宾夕法尼亚大学神经内科和艾滋病研究中心（CFAR）长期以来的艾滋病和神经病毒学医学博士/博士和临床研究培训项目。我们正在进行的项目通过共享资源、联合研讨会、研讨会、专题讨论会、邀请演讲者、论文指导和两所机构的教育活动，进一步发展全市范围内的神经艾滋病跨学科和转化研究培训项目。这两所大学的研究生课程旨在为生物医学科学提供广泛的科学基础，包括神经科学、免疫学、微生物学、药理学和生理学。本课程包括负责任的研究行为、科学传播、统计学，以及分子和细胞神经生物学、神经发病机制和转化神经科学的深入训练的高级课程。该项目汇集了多个生物医学基础科学部门，并将两个机构与附近的宾夕法尼亚大学的联合培训活动整合在一起。随着临床艾滋病研究人员的加入，以及CNAC核心设施，我们的培训计划不仅是跨学科的，而且让学生了解以艾滋病毒/艾滋病/神经艾滋病为重点的基础科学和临床观点。我们的联合培训项目，加上我们的联合基础设施资源，通过我们的CNAC和附近的宾夕法尼亚大学CFAR，在大费城地区提供了一个强大的、互动的、非常成功的神经病毒学和神经艾滋病培训环境。为了支持和加强我们在这个项目中未被充分代表的少数民族的招募，这个申请现在包括本科生和医科学生的暑期实验室培训，这将为进入我们的神经艾滋病博士和医学博士/博士培训项目提供途径。

DESCRIPTION (provided by applicant): This revised competing renewal application provides a plan for the continuation and further development of the "Interdisciplinary and Translational Research Training Program (ITRTP) in NeuroAIDS" for predoctoral students studying central nervous system complications of HIV infection and related areas of research. This is a joint program from two institutions, Temple University and Drexel University, located in close proximity in Philadelphia, Pennsylvania. This program also integrates training activities and research resources available in the Comprehensive Center for NeuroAIDS (CNAC) involving both Temple and Drexel University as well as long-standing MD/PhD and clinical research training programs in AIDS and Neurovirology based in the Department of Neurology, and Center for AIDS Research (CFAR) at the University of Pennsylvania. Our ongoing program further develops a citywide interdisciplinary and translational research training program in NeuroAIDS through shared resources, joint seminars, workshops, symposia, invited speakers, as well as thesis mentoring and educational activities at both institutions. The graduate curriculum at both institutions is designed to provide a broad based scientific foundation in biomedical sciences, including neuroscience, immunology, microbiology, and pharmacology and physiology. This curriculum includes responsible conduct of research, scientific communication, statistics, as well as advanced courses with in- depth training in molecular and cellular neurobiology, neuropathogenesis, and translational neuroscience. This program brings together multiple biomedical basic science departments and integrates joint training activities at two institutions with nearby University of Pennsylvania. With the inclusion of clinical AIDS investigators, as well as CNAC Core facilities, our training program is not only interdisciplinary, but exposes students to basic sciences and clinical perspectives focusing on HIV/AIDS/NeuroAIDS. Our joint training program, together with our joint infrastructural resources available through our CNAC and the nearby University of Pennsylvania CFAR, provides a strong, interactive, and highly successful training environment in neurovirology and NeuroAIDS within the greater Philadelphia region. In order to support and enhance our under-represented minority recruitment within this program, this application now includes the provision for summer laboratory training of undergraduates and medical students that would provide pathways for entry into our PhD and MD/PhD training program in NeuroAIDS.