Resources and Workforce Development for the Tulane Regional Biocontainment Laboratory

杜兰国家灵长类动物研究中心（TNPRC）是七个国家灵长类动物研究中心之一。 研究中心（NPRCs）致力于进行非人灵长类动物（NHP）的研究， 改善人类健康的目标。主要关注传染病和生物防御 研究，TNPRC是唯一的NPRC与区域生物遏制实验室（RBL）， 生物安全3级（BSL-3），用于研究高后果病原体，包括特定病原体 和毒素。杜兰大学RBL于2010年6月上线，对以下方面至关重要： 推进TNPRC和整个地区对生物防御剂的研究， 感染性疾病，主要集中在使用NHP的体内研究。自成立以来， 为了利用RBL的存在，已经完成了重要的基础设施项目 并在TNPRC发展和多样化研究。近年来，特别是随着 在COVID-19大流行期间，TNPRC RBL扩大了其能力和容量， 适应BSL-3级新兴病原体和生物防御研究。总体目标 拟议项目的目的是战略性地增强和巩固BSL-3的研究能力， TNPRC RBL确保该计划在支持传染病方面的长期成功 生物防御研究和对策开发。这将通过以下方式实现： （1）确保TNPRC RBL对新出现的公众的反应的敏捷性 健康问题和威胁，利用强大的研究基础设施和独特的研究 TNPRC的优势，并实施特殊的预防性维护流程， 允许最佳实践、质量控制和广泛的安全监督， 结果病原体。(2)为分享安全方面的最佳做法提供正式结构， 与合作伙伴和其他RBL进行研究程序和设施管理。(3)坐标 生物防御设施网络的做法和程序，以利用 所有12个区域基准;确保高效和有效的交叉培训和方法、标准作业程序， 协调和推进传染病和生物防御研究， 全国范围内的对策发展。

The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) dedicated to conducting nonhuman primate (NHP) research with the goal of improving human health. With a primary focus on infectious disease and biodefense research, the TNPRC is only NPRC with a Regional Biocontainment Laboratory (RBL) at Biosafety Level 3 (BSL-3) for the study of high-consequence pathogens, including select agents and toxins. The Tulane University RBL, which came online in June 2010, has been critical for advancing research at the TNPRC and across the region on biodefense agents and emerging infectious diseases, with a primary focus on in vivo studies using NHPs. Since its inception, significant infrastructure projects have been completed to capitalize on the presence of the RBL and grow and diversify research at the TNPRC. In recent years, and particularly with the onset of the COVID-19 pandemic, the TNPRC RBL has expanded its capabilities and capacity to accommodate BSL-3-level emerging pathogen and biodefense research. The overarching goal of the proposed project is to strategically enhance and fortify BSL-3 research capabilities within the TNPRC RBL to ensure the long-term success of this program in support of infectious disease and biodefense research and countermeasure development. This will be accomplished through the following Specific Aims: (1) Ensure agility of the TNPRC RBL response to emerging public health concerns and threats by leveraging the robust research infrastructure and unique research strengths of the TNPRC and implementing exceptional preventative maintenance processes that allow for best practices, quality control, and extensive safety oversight for work with high- consequence pathogens. (2) Provide formal structure for sharing of best practices for safety, research procedures and facilities management with partners and other RBLs. (3) Coordinate practices and procedures across the Biodefense Facilities Network to leverage the strengths of all 12 RBLs; ensure efficient and effective cross-training and sharing of methodologies, SOPs, and best practices; and coordinate and advance infectious disease and biodefense research and countermeasure development nation-wide.