Facility Management Maintenance Operations Core

设施管理维护运营核心

• 批准号: 10794124
• 负责人: JAY RAPPAPORT
• 金额: $ 206.47万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-22 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10794124
• 关键词: Animals; Area; Collaborations; Communicable Diseases; Complex; Containment; Data; Decontamination; Engineering; Ensure; Environment; Equipment; Funding; Future; Goals; Laboratories; Maintenance; Measures; Modeling; Occupational Health; Operations Research; Primates; Procedures; Public Health; Quality Control; Reproducibility; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Resource Development; Risk; Role; Scientist; Security; Services; Standardization; Structure; System; Toxin; Waste Management; Workforce Development; biodefense; containment equipment; good laboratory practice; high risk; operation; pandemic response; pathogen; professional atmosphere; programs; quality assurance; response

The Biocontainment Operations core (Core 1) contributes to the operation and support of the high-containment research needs of the Regional Biocontainment Laboratory (RBL) at the Tulane National Primate Research Center (TNPRC). This core provides comprehensive services, available to core and affiliate scientists, to coordinate all aspects of high-containment research involving Risk Group 3 pathogens, select agents, and toxins and ensure compliance and efficient use of high-containment spaces. By coordinating facilities and research-related needs that must be integrated according to complex procedures and regulatory requirements in this high- containment research environment, Biocontainment Operations comprehensively supports investigators performing complex, high risk, and highly regulated research within the high- containment spaces in the RBL, including two Biosafety Level 3 (BSL-3) spaces, the Animal Biosafety Level 3 (ABSL-3) complex, and supporting areas. Additionally, the core is host to the TNPRC Quality Assurance Program, which provides services essential for attainment of rigorous and reproducible scientific data across all research activities at the TNPRC through implementation of quality standards guided by Good Laboratory Practices. The Specific Aims for this proposal include: (1) Develop an efficient and standardized approach to preventative maintenance and quality control of critical pieces of biocontainment equipment within the TNPRC RBL structure to include building systems, decontamination equipment, and primary containment equipment. (2) Develop practices for laboratory level equipment for biocontainment research procedures to ensure high levels of quality assurance and quality control to provide guarantee of rigor and reproducibility for data generated through studies. (3) Ensure adaptability to changing needs of the response environment to expand normal operating capacities during a public health, pandemic response, or biodefense response to meet critical biosafety measures and select agent requirements. The proposed UC7 will enhance the management of core maintenance, preventative maintenance, and operations and ensure continuity of support for all high- containment research operations with the highest level of biosafety compliance expertise and quality assurance oversight focused on ensuring rigor and reproducibility. Furthermore, these funds will guarantee that the TNPRC RBL is ready and able to support the incredible surge of capacity demand in the face of future public health, biodefense, and pandemic response needs.

生物防护运行核心（核心1）有助于 杜兰大学区域生物防护实验室（RBL）的高防护研究需求 国家灵长类动物研究中心（TNPRC）。该核心提供全面的服务， 提供给核心和附属科学家，以协调高遏制研究的各个方面 涉及风险组3病原体、特定物剂和毒素，并确保合规和高效 使用高度封闭的空间。通过协调设施和研究相关需求， 根据复杂的程序和监管要求，在这个高- 安全壳研究环境，生物安全壳操作全面支持 研究人员在高风险、高监管的环境中进行复杂、高风险和高监管的研究， RBL中的封闭空间，包括两个生物安全3级（BSL-3）空间，动物 生物安全3级（ABSL-3）综合体和支持区域。此外，核心是 TNPRC质量保证计划，为实现严格的 和可重复的科学数据在所有的研究活动在TNPRC通过 实施以良好实验室规范为指导的质量标准。具体目标为 该建议包括：（1）制定有效和标准化的预防方法， 对TNPRC内生物防护设备的关键部件进行维护和质量控制 RBL结构包括建筑系统、去污设备和一级安全壳 设备. (2)为生物防护研究制定实验室级设备的做法 程序，以确保高水平的质量保证和质量控制，以提供保证 通过研究生成的数据的严谨性和可重复性。(3)确保适应变化 应对环境的需求，以扩大公共卫生期间的正常运作能力， 大流行病应对或生物防御应对，以满足关键的生物安全措施和选择剂 要求.拟议的UC 7将加强核心维护的管理， 预防性维护和运营，并确保对所有高 具有最高水平生物安全合规专业知识的遏制研究业务， 质量保证监督的重点是确保严格性和可重复性。而且这些 资金将保证TNPRC RBL准备好并能够支持令人难以置信的激增， 面对未来的公共卫生、生物防御和流行病应对需求的能力需求。