Facility Management Maintenance Operations Core

生物遏制行动核心(核心1)有助于 杜兰地区生物遏制实验室(RBL)的高遏制研究需求 国家灵长类研究中心。该核心提供全面的服务， 可供核心和附属科学家使用，以协调高遏制研究的所有方面 涉及风险组3病原体、精选制剂和毒素，并确保合规和高效 使用高密封性空间。通过协调必须满足的设施和研究相关需求 根据复杂的程序和监管要求整合到此高- 遏制研究环境，生物遏制行动全面支持 调查人员在高风险和高度监管的环境中进行复杂、高风险的研究 RBL中的遏制空间，包括两个生物安全3级(BSL-3)空间，动物 生物安全3级(ABSL-3)综合体和支持区。此外，核心驻留在 TNPRC质量保证计划，该计划提供达到严格要求所必需的服务 以及TNPRC所有研究活动的可重复使用的科学数据 在实验室良好操作规范指导下实施质量标准。具体目标是 这项建议包括：(1)制定有效和标准化的预防方法 TNPRC内关键生物遏制设备的维护和质量控制 RBL结构，包括建筑系统、净化设备和初级安全壳 设备。(2)为生物遏制研究开发实验室级设备的实践 确保高水平的质量保证和质量控制的程序提供保证 通过研究产生的数据的严密性和可重复性。(三)确保应变能力 在公共卫生期间扩大正常运作能力的反应环境的需要， 大流行应对，或生物防御应对，以满足关键的生物安全措施和选择制剂 要求。拟议的UC7将加强核心维护的管理， 预防性维护和运营，并确保对所有高 具有最高水平的生物安全合规专业知识和 质量保证监督的重点是确保严密性和可重复性。此外，这些 资金将保证TNPRC RBL准备好并有能力支持令人难以置信的 面对未来的公共卫生、生物防御和大流行应对需求的能力需求。

The Biocontainment Operations core (Core 1) contributes to the operation and support of the high-containment research needs of the Regional Biocontainment Laboratory (RBL) at the Tulane National Primate Research Center (TNPRC). This core provides comprehensive services, available to core and affiliate scientists, to coordinate all aspects of high-containment research involving Risk Group 3 pathogens, select agents, and toxins and ensure compliance and efficient use of high-containment spaces. By coordinating facilities and research-related needs that must be integrated according to complex procedures and regulatory requirements in this high- containment research environment, Biocontainment Operations comprehensively supports investigators performing complex, high risk, and highly regulated research within the high- containment spaces in the RBL, including two Biosafety Level 3 (BSL-3) spaces, the Animal Biosafety Level 3 (ABSL-3) complex, and supporting areas. Additionally, the core is host to the TNPRC Quality Assurance Program, which provides services essential for attainment of rigorous and reproducible scientific data across all research activities at the TNPRC through implementation of quality standards guided by Good Laboratory Practices. The Specific Aims for this proposal include: (1) Develop an efficient and standardized approach to preventative maintenance and quality control of critical pieces of biocontainment equipment within the TNPRC RBL structure to include building systems, decontamination equipment, and primary containment equipment. (2) Develop practices for laboratory level equipment for biocontainment research procedures to ensure high levels of quality assurance and quality control to provide guarantee of rigor and reproducibility for data generated through studies. (3) Ensure adaptability to changing needs of the response environment to expand normal operating capacities during a public health, pandemic response, or biodefense response to meet critical biosafety measures and select agent requirements. The proposed UC7 will enhance the management of core maintenance, preventative maintenance, and operations and ensure continuity of support for all high- containment research operations with the highest level of biosafety compliance expertise and quality assurance oversight focused on ensuring rigor and reproducibility. Furthermore, these funds will guarantee that the TNPRC RBL is ready and able to support the incredible surge of capacity demand in the face of future public health, biodefense, and pandemic response needs.