Acute Alcohol Effects on Impulsivity and Risk for Drinking and Driving

描述（由申请人提供）：酒后驾驶仍然是一个主要的公共卫生问题，特别是对年轻人来说，他们报告的酒后驾驶率最高。虽然政策的变化（最低法律的饮酒年龄;本身的法律）已成功地减少酒后驾车，个别差异因素使某些人酒后驾车。研究清楚地表明，冲动是这样一个个体差异因素。然而，到目前为止，冲动性对酒后驾驶的影响主要是使用冲动人格特质的问卷调查。没有以前的研究探讨了急性酒精对冲动行为的影响及其与饮酒和驾驶行为的关系的个体差异。拟议的项目将测试一个酒后驾车的模型，该模型受到酒精对两个冲动性结构的急性影响：行为抑制（即，抑制/抑制行为的能力）和冲动决策（即，根据时间和可能发生的意外情况作出决定的能力）。参与者将从一项正在进行的纵向研究（PI：Kenneth Sher，R37 AA 07231）中抽取，该研究基于他们饮酒和驾驶行为的纵向过程。所有参与者将在两次实验室会议（酒精，无饮料控制）中完成冲动性的多种行为测量，以及对他们的饮酒和驾驶行为以及特定于饮酒和驾驶的风险变量进行为期3个月的随访评估。拟议的项目有三个具体目标：1）测试清醒和醉酒冲动与酒后驾驶的参与和持续性的关联。2)测试酒精对冲动性的影响如何受到其他饮酒风险因素的影响。3)测试冲动和特定于酒后驾驶的风险因素之间的相互作用，以确定酒后驾驶行为。拟议项目的结果可以通过描述醉酒冲动在酒后驾驶决策中的作用来推进酒后驾驶理论，研究和干预。

DESCRIPTION (provided by applicant): Driving after consuming alcohol continues to be a major public health problem, particularly for young adults, who report the highest rates of drinking and driving. Although changes in policy (minimum legal drinking age; per se laws) have been successful in reducing drinking and driving, individual difference factors predispose certain people to drive after drinking. Research clearly demonstrates that impulsivity is one such individual difference factor. However, to date the influence of impulsivity on drinking and driving has primarily been examined using questionnaire measures of impulsive personality traits. No previous study has examined individual differences in acute alcohol effects on behavioral measures of impulsivity and their association with drinking and driving behavior. The proposed project will test a model of drinking and driving as influenced by the acute effect of alcohol on two impulsivity constructs: behavioral inhibition (i.e., the ability to inhibit/suppress behavior) and impulsive decision making (i.e., the ability to make decisions in accordance with time and probability contingencies). Participants will be drawn from an ongoing longitudinal study (PI: Kenneth Sher, R37 AA07231) based on the longitudinal course of their drinking and driving behavior. All participants will complete multiple behavioral measures of impulsivity in two laboratory sessions (alcohol, no beverage control), as well as a 3 month follow-up assessment of their drinking and driving behavior and risk variables specific to drinking and driving. The proposed project has three specific aims: 1) Test the association of sober and intoxicated impulsivity with engagement in and persistence of drinking and driving. 2) Test how the effect of alcohol on impulsivity is moderated by other risk factors for alcohol use. 3) Test the interaction between impulsivity and risk factors specific to drinking and driving in determining drinking and driving behavior. Results of the proposed project can advance drinking and driving theory, research, and intervention by delineating the role of intoxicated impulsivity in drinking and driving decisions.