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Capacity and Mechanisms of Beta Cell Regeneration in Humans

人类β细胞再生的能力和机制

基本信息

批准号：
8627827
负责人：
Peter Cawood Butler
金额：
$ 33.5万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-01-15 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8627827
关键词：
2 year old 5 year old Adult Affect Agreement Apoptosis Beta Cell Biological Assay Birth Brain Death Candidate Disease Gene Cell Lineage Cell Maturation Cell physiology Cells Complement Complex Data Development Diabetes Mellitus Diabetic mouse Disease Endocrine Endocrine Glands Enterocytes Exocrine pancreas Fostering Genes Genetic Gland Glucagon Grant Health Human Hyperplasia Immunosuppression In Situ Inflammation Insulin Insulin-Dependent Diabetes Mellitus Islets of Langerhans Lasers Life Molecular Profiling Mus Mutation Natural regeneration Non-Insulin-Dependent Diabetes Mellitus Organ Donor PTGS1 gene Pancreas Pancreas Transplantation Pancreatic duct Patients Phenotype Pilot Projects Pregnancy Proliferating Rodent Signal Pathway Signal Transduction Source Stem cells Testing Therapeutic Translating aged aldehyde dehydrogenases base cell type chronic pancreatitis cytochrome c oxidase cytokine glucagon-like peptide 1 insight insulin secretion intestinal crypt intestinal villi islet islet stem cells non-diabetic novel postnatal human progenitor public health relevance response transcriptome sequencing

项目摘要

DESCRIPTION (provided by applicant): Both type 1 and 2 diabetes are caused by inadequate insulin secretion, and in both diseases this can be ascribed in large part to loss of pancreatic ¿-cells that produce insulin. Both diseases can be cured by replacement of pancreatic ¿-cells by pancreas transplantation but this requires life-long immunosuppression and there are far fewer organ donors than people with diabetes. An alternative approach to restoring pancreatic ¿-cells is to foster regeneration of ¿-cells in the patient. Recent studies in mice have provided important insights into how ¿-cells are formed and their number increased and maintained after birth. Complementary studies in humans are few because of the difficulty in obtaining appropriate material and the difficulty of undertaking lineage tracing studies in humans.

描述(申请人提供)：1型和2型糖尿病都是由胰岛素分泌不足引起的，在这两种疾病中，这在很大程度上可以归因于分泌胰岛素的胰腺细胞的丧失。这两种疾病都可以通过胰腺移植替换胰腺细胞来治愈，但这需要终生的免疫抑制，而且器官捐赠者比糖尿病患者少得多。另一种恢复胰腺细胞的方法是促进患者体内细胞的再生。最近对小鼠的研究提供了重要的洞察细胞是如何形成的，它们的数量在出生后增加并保持。人类补充研究很少，因为很难获得合适的材料，也很难进行人类血统追踪研究。