Developmental Research Program

计划说明 发展研究计划一直是孢子中最有价值和最有成效的计划之一 组件。卵巢癌的创新翻译研究概念的发展至关重要 取决于试点项目是否有灵活的资金来源。孢子发育的目的 研究计划是鼓励和开发具有翻译潜力的研究项目，这将减少 卵巢癌的发病率和死亡率或提高存活率和生活质量。实验室和临床都有 研究项目只要是翻译性质的，就有资格获得资助。孢子的一部分 预算(直接费用为90000美元)每年用于支持试点项目。每个人的资助限额为40,000美元 每个项目每年。我们将从卵巢孢子机构匹配中额外提供高达10,000美元 为每个项目提供40,000美元的资金。至少有三个项目已经实施并将继续实施 每年资助一次。资金最初是第一年的，可以续期一年；现在申请者将有 一次申请两年资助的选项。两年期提案的第二年资金将取决于 关于第一年取得的进展，该提案将与新的资金申请竞争。 发展研究计划的目的是资助任何年龄段的研究人员的有前途的项目 他们的工作可能并不完全集中在卵巢癌上，但他们提出了创新的翻译研究 卵巢癌可能成为全孢子项目或在外部成功竞争资金 孢子。 发展研究方案的目标如下： 宣传卵巢癌转化研究试点项目的启动资金可获得性。 确定在降低卵巢癌发病率方面具有创新性和巨大潜力的项目 无论是为了降低死亡率还是为了提高生存和生活质量。 鼓励孢子内科学家和孢子外科学家之间的合作 环境。 帮助潜在的试点项目调查人员定义和阐明翻译研究目标和步骤 需要将研究有益地转化为对人类的应用。 使用内部和外部审查员选择相互竞争的研究提案，以获得资金 标准。 为孢子研究所的研究人员和其他选定地点的科学家提供发展资金。 密切监督并与开发项目调查员合作，协助他们实现翻译研究目标。 管理一个灵活的计划，在该计划中，展示前景的试点项目将遵循以下三个课程之一：a)它们将再获得一年的资金，如果特别有希望，可能还会获得额外的支持；b)它们将被提升为完整的孢子项目；或c)将鼓励研究人员申请R01或其他同行审查的研究支持。未发挥潜力的开发项目将被终止。

Program Description The Developmental Research Program has been one of the most valuable and productive of the SPORE components. The development of innovative translational research concepts in ovarian cancer is critically dependent on the availability of flexible funding for pilot projects. The purpose of the SPORE Developmental Research Program is to encourage and develop research projects with translational potential that will reduce ovarian cancer incidence and mortality or improve survival and quality of life. Both laboratory and clinical research projects are eligible for funding, provided that they are translational in nature. A portion of the SPORE budget ($90,000 in direct costs) is allocated annually to support pilot projects. Funding is limited to $40,000 per year per project. We will provide up to an additional $10,000 from the Ovarian SPORE Institutional Matching funds in order to fund at the $40,000 per project level. At least three projects have been and will continue to be funded annually. Funding was initially f o r i year and was renewable for another year; now applicants will have the option to apply for 2 years of funding at once. Second-year funding of a 2-year proposal will be dependent on the progress made in the first year, and the proposal will compete with new applications for funding. The purpose of the Developmental Research Program is to fund promising projects by investigators of any age whose work may not focus exclusively on ovarian cancer, but who propose innovative translational studies of ovarian cancer that could become full SPORE projects or compete successfully for funding outside of the SPORE. The objectives of the Developmental Research Program are as follows: Publicize the availability of start-up funding for pilot projects in ovarian cancer translational research. Identify projects that are innovative and have significant potential for reducing ovarian cancer incidence and mortality or for improving survival and quality of life. Encourage collaborations among scientists within the SPORE and with scientists outside the SPORE environment. Help potential pilot project investigators define and articulate translational research goals and the steps required to beneficially translate research into application in humans. Select competing research proposals for funding using internal and external reviewers applying specific criteria. Provide developmental funding for investigators in the SPORE institution and scientists at other selected sites. Closely monitor and work with the Developmental Project investigators to assist them in achieving their translational research goals. Administer a flexible program in which pilot projects that demonstrate promise follow one of three courses: a) They will be funded for another year, possibly with additional support if particularty promising; b) They will be elevated to full SPORE projects; or c) Investigators will be encouraged to apply for an R01 or other peer-reviewed research support. Developmental projects that do not reach their potential will be terminated.