Representation and Binding of Spatial and Temporal Episodic Memories in Human Hip

人类髋关节空间和时间情景记忆的表征和结合

• 批准号: 8611401
• 负责人: ARNE D EKSTROM
• 金额: $ 5.46万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8611401
• 关键词: Accounting; Address; Affect; Architecture; Area; Binding; Brain region; Code; Complement; Confusion; Disease; Disorientation; Electroencephalography; Elements; Epilepsy; Episodic memory; Event; Functional Magnetic Resonance Imaging; Goals; Hip region structure; Hippocampus (Brain); Hospitals; Human; Impairment; Learning; Link; Maps; Memory; Mental disorders; Methods; Modeling; Monitor; Neurodegenerative Disorders; Neurologist; Neurosurgeon; Patients; Phase; Play; Process; Property; Recurrence; Relative (related person); Research; Research Personnel; Resolution; Rodent; Role; Schizophrenia; Seizures; Seminal; Source; Stroke; Structure; Symptoms; Testing; Time; Work; base; dentate gyrus; hippocampal subregions; imaging modality; innovation; insight; nervous system disorder; neuroimaging; neuromechanism; neurophysiology; novel; novel strategies; relating to nervous system; research study; way finding

DESCRIPTION (provided by applicant): The goal of this project is to determine the neural basis of human episodic memory using an innovative combination of high-resolution functional magnetic resonance imaging (fMRI) and intracranial EEG (iEEG). Episodic memory involves knowing where and when an event occurred relative to other events, both of which depend critically on the hippocampus. Yet exactly how and in what manner the hippocampus codes spatial and temporal aspects of episodic memory remains unclear and understudied, particularly in humans where the primary focus of research has been on verbal episodic memory. Using a newly developed experimental paradigm from our lab, we will study the spatial and temporal components of episodic memory, focusing on two critical processes underlying these components: representation and binding. To map these onto the hippocampal circuit, we employ high-resolution fMRI. In contrast to some previous models developed in the rodent, we hypothesize that spatio-temporal representation is a function shared across hippocampal subregions but that subregion CA3/DG plays a distinct role in parsing elements of context to represent an episode. We further hypothesize a central role for hippocampal subregion CA1 in spatio-temporal binding based on its unique connectivity, in contrast to previous models that have focused on CA3/DG. Collaborating with a team of neurologists and neurosurgeons at two different hospitals, we will also employ iEEG in patients undergoing seizure monitoring. This complementary approach will allow us to determine a separate yet critical component of episodic memory: how does coordinated neural activity in the hippocampus, long linked with spatial navigation in the rodent but understudied in humans, underlie representation and binding of spatio-temporal memory? Overall, our proposed experiments will provide novel insight into the neural basis of episodic memory as they take a new approach to this issue paradigmatically and methodologically and allow us to test several different models of hippocampal function, including our model. Neurodegenerative diseases such as stroke, epilepsy, and schizophrenia impact hippocampal subregion function and coordinated neural activity there, often resulting in symptoms of spatial disorientation and temporal confusion in patients afflicted with these conditions. Our approach thus will also have significant implications for neural diseases that affect the hippocampus.

描述(申请人提供)：该项目的目标是使用高分辨率功能磁共振成像(FMRI)和颅内脑电(IEEG)的创新组合来确定人类情节记忆的神经基础。情节记忆包括知道一个事件相对于其他事件发生的地点和时间，这两者都严重依赖于海马体。然而，海马体如何以及以何种方式编码情节记忆的空间和时间方面仍然不清楚，研究也很少，特别是在人类身上，因为研究的主要焦点一直是言语情节记忆。使用我们实验室新开发的实验范式，我们将研究情景记忆的空间和时间成分，重点研究这些成分背后的两个关键过程：表征和绑定。为了将它们映射到海马区，我们使用了高分辨率的功能磁共振成像。与以前在啮齿动物中发展的一些模型不同，我们假设时空表征是海马亚区共有的功能，但CA3/DG亚区在解析上下文元素以表征情节方面发挥着独特的作用。基于其独特的连接性，我们进一步假设海马亚区CA1在时空结合中扮演中心角色，而不是以前专注于CA3/DG的模型。与两家不同医院的神经学家和神经外科医生团队合作，我们还将在接受癫痫监测的患者中使用iEEG。这种互补的方法将使我们能够确定情节记忆的一个单独但关键的组成部分：海马体中的协调神经活动是如何作为时空记忆的表征和绑定的基础的？长期以来，海马体与啮齿动物的空间导航有关，但在人类中研究得较少。总体而言，我们提出的实验将为情节记忆的神经基础提供新的见解，因为它们在范式和方法上为这个问题采取了一种新的方法，并允许我们测试几种不同的海马体功能模型，包括我们的模型。神经退行性疾病，如中风、癫痫和精神分裂症，会影响海马区的功能和协调神经活动，通常会导致患有这些疾病的患者出现空间定向障碍和时间混乱的症状。因此，我们的方法也将对影响海马体的神经疾病产生重大影响。