Applications of methods in collaborative science

在NIEHS早期妊娠研究的相关工作中，我们有一篇正在修订的论文，该论文考虑了生育能力，早期妊娠丢失和月经周期特征与双酚a和邻苯二甲酸盐水平的关系，这些水平是通过EPS收集的每日尿液样本测量的。NHANES项目基本上是阴性的，只有一个例外是三氯生在男性中，这与抗核抗体的存在密切相关。那篇论文马上就要提交了。在另一个基于NHANES数据和ANA女性生殖史的项目中，发现与ANA患病率相关，胎次与这种自身免疫生物标志物的较高患病率相关。一项由国防部资助的军事人员自身免疫性疾病肌炎与他们在服役期间所经历的暴露有关的研究目前正在开展合作工作。这个项目的PI是Fred Miller （NIEHS）。我们在与卑尔根大学和挪威医学出生登记处合作的基础上还有另一套项目。我们已经分析了挪威的季节对早产的影响，并准备提交一篇论文，我们已经开始分析季节与先兆子痫的关系。

In work related to the NIEHS Early Pregnancy Study we have a paper under revision that considers fertility, early pregnancy loss and menstrual cycle characteristics in relation to levels of bisphenol A and phthalates, as measured in the daily urine samples collected in the EPS. The NHANES project was largely negative, with the one exception being triclosan in males, which was strongly related to the presence of antinuclear antibodies. That paper is very close to ready for submission. In another project based on NHANES data and ANA reproductive history in women was found to be related to the prevalence of ANA, with parity being associated with higher prevalence of this autoimmunity biomarker. Collaborative work is now beginning on a DoD-funded study of the auto-immune disease myositis in military personnel in relation to exposures experienced during their years of military service. The PI on this project is Fred Miller (NIEHS). We have another set of projects based on collaboration with the University of Bergen and the Medical Birth Registry of Norway. We have analyzed seasonal effects on preterm birth in Norway and have a paper almost ready to submit, and we have begun analysis of season in relation to preeclampsia.