Applications of methods in collaborative science

方法在协作科学中的应用

• 批准号: 10007481
• 负责人: Clarice Weinberg
• 金额: $ 7.07万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10007481
• 关键词: Air Pollution; Antinuclear Antibodies; Area; Autoimmune Diseases; Award; Back; Biological; Biological Markers; Biometry; Birth; Carbon Monoxide; China; Chinese People; Collaborations; Data; Epidemiology; Epigenetic Process; Exposure to; Family; Fertility; Genes; Genetic; Genetic study; Grant; Health Surveys; Hour; Inflammation; Inflammatory; Joints; Length; Long-Term Effects; Malignant Childhood Neoplasm; Maternal Age; Mediating; Methodology; Methods; Methylation; Mothers; National Health and Nutrition Examination Survey; National Institute of Environmental Health Sciences; Neuroblastoma; Nitric Oxide; Paper; Participant; Particulate; Pathway interactions; Population; Postdoctoral Fellow; Pre-Eclampsia; Pregnancy Complications; Publishing; Research; Research Personnel; Science; Scientist; Signal Transduction; Sister; Students; Time; Time trend; United States National Institutes of Health; Vitamin A; Vitamin D; Woman; Work; base; design; early pregnancy; follow-up; genetic variant; multidisciplinary; ovarian reserve; phthalates; reproductive; reproductive epidemiology; tenure track

In work collaborative with a student at UNC (Bauer, et al.) we explored genetic variants related to nitric oxide signaling and carbon monoxide in relation to preeclampsia, using a family-based design. A second project with a UNC student (Mazul, et al.), which concerned neuroblastoma, used genetic data from cases and their mothers to look at joint effects of vitamin A and related genes. Another project (Wang, et al.) had to do with air pollution and effects on inflammatory pathways that may be mediated by methylation. We found short-term effects (within 24 hours) based on a panel study of healthy students in Shanghai. A related second paper is undergoing review, which was based on long-term effects of ambient levels, using US data from the Sister Study. Some reproductive epidemiology related to Ann Steiners "Time to Conceive" study was published this year, based on effects of vitamin D on cycle length and ovarian reserved (Jukic, et al.). Another paper on effects of vitamin D on fecundability is now in revision.

在工作中与一个学生在ESTA（鲍尔，等人）我们使用基于家族的设计，探索了与先兆子痫相关的一氧化氮信号传导和一氧化碳的遗传变异。第二个项目是与一名学生合作（Mazul等人），该研究涉及神经母细胞瘤，使用病例及其母亲的遗传数据来研究维生素A和相关基因的联合作用。 另一个项目（Wang等人）与空气污染和对可能由甲基化介导的炎症途径的影响有关。 我们发现短期影响（24小时内）的基础上，在上海健康学生的小组研究。第二篇相关论文正在审查中，该论文基于环境水平的长期影响，使用了美国的姐妹研究数据。今年发表了一些与Ann Steiners“受孕时间”研究相关的生殖流行病学，该研究基于维生素D对周期长度和卵巢储备的影响（Jukic等人）。另一篇关于维生素D对生育力影响的论文正在修订中。