Mechanisms of HSK amelioration
Mechanisms of HSK amelioration
批准号:
8597431
负责人:
Patrick M Stuart
金额:
$33.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-01-01 至 2015-12-31
关键词:
AddressAntigensBiologyBlindnessCCL2 geneCCL3 geneCCL4 geneCD28 geneCD4 Positive T LymphocytesCD80 geneCXCR3 geneCell surfaceCellsCellular InfiltrationCicatrixClinicalClinical PathologyComparative StudyCorneaCorneal DiseasesCountryDataDefective VirusesDendritesDiseaseEpithelialExperimental ModelsEyeGenerationsGenesGlycoproteinsHerpesviridaeHerpesvirus 1Herpetic KeratitisHumanIL8 geneImmuneImmune responseImmunotherapyIncidenceInfectionInflammationInflammatoryInflammatory InfiltrateInterleukin-6KeratitisKeratoplastyLaboratoriesLeadMacrophage Inflammatory Protein-1MaintenanceMediatingModelingMolecular ProfilingMusNIH MousePathogenesisPathologyPhenotypePlayProteinsRecording of previous eventsRecurrenceRecurrent diseaseRelative (related person)ReportingResistanceRoleSimplexvirusT-LymphocyteTNFRSF5 geneTNFSF5 geneTestingTherapeutic InterventionTimeUnited StatesVaccinatedVaccinationVaccine TherapyVaccinesViralViral AntigensVirusVirus DiseasesVirus LatencyWomanWorkbasechemokinecytokinedesigngenital herpeshuman diseaseimprovedmacrophageneovascularizationpreventprophylacticreactivation from latencyresponsesuccessvaccine evaluationvirus host interaction
中文摘要
疱疹性间质角膜炎(HSK)是中国传染性失明的主要原因
英文摘要
Herpetic stromal keratitis (HSK) is a leading cause of infectious blindness in the
United States. Visual loss most commonly results from recurrent stromal
disease, as opposed to primary HSK and appears to be the result of immune-
mediated corneal destruction. Most experimental models have focused on
primary rather than recurrent keratitis. We study a model of recurrent HSK that
mimics many clinical and immunological features of recurrent HSK in humans.
While current data indicates that primary and recurrent HSK are similar, there are
significant differences in the clinical pathology, viral antigen distribution, cellular
infiltration within the cornea, importance of both some cytokines and chemokines
and responses to vaccine therapy, thus suggesting that the immune responses in
these two diseases is not identical. Over the past 15+ years our and a few other
labs have characterized much of what is known concerning recurrent HSK.
Based on our most recent data concerning the role that costimulatory molecules
play in HSK as we have demonstrated the central role that CD28 plays in
mediating this disease, but at the same time is involved in suppressing
spontaneous viral reactivation from latency. We have also shown that CD137L is
likely involved in disease amelioration. These data further support the notion that
HSK is mediated by CD4+ cells of the Th1 phenotype and that more importantly,
Th2 T cells are strongly associated with less disease. In order to test these
hypotheses we will: (1) Determine the role that the proinflammatory molecules
IL-6, KC (IL-8), IP10 (CXCL10), and CCL4 play in recurrent HSK disease
pathogenesis. (2) Determine the role that co-stimulatory interactions play in both
recurrent HSK and in maintenance of viral latency. (3) We will also determine
whether therapeutic intervention, either targeting or promoting these interactions,
will ameliorate disease using a vaccination paradigm. The information derived
from these studies will lead to a better understanding of the biology of recurrent
HSK in mice and by extension human disease. Furthermore, these studies could
possibly suggest more effective immunotherapies designed to ameliorate human
HSK disease.
期刊论文(5)
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CD137 costimulation is associated with reduced herpetic stromal keratitis and with developing normal CD8+ T cells in trigeminal ganglia.
CD137 共刺激与疱疹性基质角膜炎的减少以及三叉神经节中正常 CD8 T 细胞的发育有关。
DOI:
10.1099/jgv.0.001756
发表时间:
2022
期刊:
The Journal of general virology
影响因子:
--
作者:
[Yin,Xiao-Tang, Baugnon,NicholasK, Krishnan,Rohini, Potter,ChloeA, Yarlagadda,Sudha, Keadle,TammieL, Stuart,PatrickM]
通讯作者:
Stuart,PatrickM
CD28 Costimulation Is Required for Development of Herpetic Stromal Keratitis but Does Not Prevent Establishment of Latency.
CD28 共刺激对于疱疹性基质性角膜炎的发展是必需的,但不能阻止潜伏期的建立。
DOI:
10.1128/jvi.00659-19
发表时间:
2019
期刊:
Journal of virology
影响因子:
5.4
作者:
[Yin,Xiao-Tang, Baugnon,NicholasK, Potter,ChloeA, Tai,Shannon, Keadle,TammieL, Stuart,PatrickM]
通讯作者:
Stuart,PatrickM
Herpes simplex keratitis: challenges in diagnosis and clinical management.
单纯疱疹性角膜炎:诊断和临床管理方面的挑战。
DOI:
10.2147/opth.s80475
发表时间:
2017
期刊:
Clinical ophthalmology (Auckland, N.Z.)
影响因子:
--
作者:
[Azher TN, Yin XT, Tajfirouz D, Huang AJ, Stuart PM]
通讯作者:
Stuart PM
DOI:
10.3389/fmicb.2021.798927
发表时间:
2021
期刊:
Frontiers in microbiology
影响因子:
5.2
作者:
[Krishnan R, Stuart PM]
通讯作者:
Stuart PM
Mechanisms of HSK amelioration
-
批准号:8389553
-
项目类别:
-
资助金额:$35.63万
-
财政年份:2011
-
负责人:Patrick M Stuart
-
依托单位:
Mechanisms of HSK amelioration
-
批准号:8026561
-
项目类别:
-
资助金额:$36.25万
-
财政年份:2011
-
负责人:Patrick M Stuart
-
依托单位:
Mechanisms of HSK amelioration
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批准号:8207849
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项目类别:
-
资助金额:$37.5万
-
财政年份:2011
-
负责人:Patrick M Stuart
-
依托单位:
THE ROLE OF APOPTOTIC MOLECULES IN HERPETIC STROMAL
-
批准号:7526460
-
项目类别:
-
资助金额:$35.3万
-
财政年份:2009
-
负责人:Patrick M Stuart
-
依托单位:
THE ROLE OF APOPTOTIC MOLECULES IN HERPETIC STROMAL
-
批准号:7935224
-
项目类别:
-
资助金额:$34.44万
-
财政年份:2009
-
负责人:Patrick M Stuart
-
依托单位:
FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
-
批准号:6384835
-
项目类别:
-
资助金额:$32.37万
-
财政年份:1999
-
负责人:Patrick M Stuart
-
依托单位:
FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
-
批准号:2899161
-
项目类别:
-
资助金额:$27.25万
-
财政年份:1999
-
负责人:Patrick M Stuart
-
依托单位:
FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
-
批准号:6179299
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项目类别:
-
资助金额:$26.94万
-
财政年份:1999
-
负责人:Patrick M Stuart
-
依托单位:
FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
-
批准号:6951737
-
项目类别:
-
资助金额:$5.36万
-
财政年份:1999
-
负责人:Patrick M Stuart
-
依托单位:
FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
-
批准号:6414277
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项目类别:
-
资助金额:$6.49万
-
财政年份:1999
-
负责人:Patrick M Stuart
-
依托单位:
FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
-
批准号:6524983
-
项目类别:
-
资助金额:$33.2万
-
财政年份:1999
-
负责人:Patrick M Stuart
-
依托单位:
FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
-
批准号:6637194
-
项目类别:
-
资助金额:$29.44万
-
财政年份:1999
-
负责人:Patrick M Stuart
-
依托单位:
AMELIORATION OF RECURRENT HERPES KERATITIS
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批准号:6384708
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项目类别:
-
资助金额:$22.92万
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财政年份:1998
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负责人:Patrick M Stuart
-
依托单位:
Amelioration of recurrent herpes keratitis
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批准号:6617615
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项目类别:
-
资助金额:$37.08万
-
财政年份:1998
-
负责人:Patrick M Stuart
-
依托单位:
Amelioration of recurrent herpes keratitis
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批准号:6751542
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项目类别:
-
资助金额:$36.12万
-
财政年份:1998
-
负责人:Patrick M Stuart
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依托单位:
Amelioration of recurrent herpes keratitis
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批准号:6895084
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项目类别:
-
资助金额:$37.31万
-
财政年份:1998
-
负责人:Patrick M Stuart
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依托单位:
Amelioration of recurrent herpes keratitis
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批准号:7059913
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项目类别:
-
资助金额:$37.63万
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财政年份:1998
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负责人:Patrick M Stuart
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依托单位:
Amelioration of recurrent herpes keratitis
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批准号:7233139
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项目类别:
-
资助金额:$38.64万
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财政年份:1998
-
负责人:Patrick M Stuart
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依托单位:
AMELIORATION OF RECURRENT HERPES KERATITIS
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批准号:6179213
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项目类别:
-
资助金额:$22.41万
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财政年份:1998
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负责人:Patrick M Stuart
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依托单位:
IA INDUCTION/EXPRES'N IN NON-BONE MARROW-DERIVED CELLS
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批准号:3029218
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项目类别:
-
资助金额:$2.93万
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财政年份:1989
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负责人:Patrick M Stuart
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依托单位:
国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
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批准号:2022J011295
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项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:王亚伟
-
依托单位:
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究
-
批准号:30801055
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项目类别:青年科学基金项目
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资助金额:19.0万元
-
批准年份:2008
-
负责人:王丽梅
-
依托单位: