Training Grant in Genomic Analysis and Interpretation

基因组分析和解释培训补助金

• 批准号: 8698794
• 负责人: Kenneth L Lange
• 金额: $ 31.2万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8698794
• 关键词: Genomics; Grant; Training

DESCRIPTION (provided by applicant): Turning the data collected by the recent quantum leap in DNA sequencing technology into useful biomedical knowledge is one of the greatest scientific challenges of the 21st Century. The enormous volume of DNA data now collected cannot be accessed, manipulated, or analyzed without computers. However, the greatest bottlenecks involve software rather than hardware. In spite of current levels of sophistication, we still lack adequate theory and algorithms to perform many fundamental tasks in molecular genetics and genetic epidemiology with speed and precision. It will take a new generation of scientists trained in both the biological and mathematical sciences to push forward our nation's genomic agenda. Few universities have the infrastructure and human resources to mount a genomic analysis training program of the scope possible at UCLA. Our training program's core curriculum includes work in molecular biology, human genetics, probability and statistics, bioinformatics, and biomedical ethics. Students must also prepare for and attend pertinent weekly scientific seminars. The trainees collectively meet on a monthly basis with the program faculty and directors to learn about career matters not covered in regular coursework. Each year we will train 12 predoctoral students drawn preferentially from students in the first half of their doctoral programs. Each trainee will be funded for two years contingent on satisfactory progress. In exceptional cases a third year of funding will be considered. This training grant has brought together faculty from four schools and 14 PhD-granting departments within the university to address the current gap in scientific training. During the years 2002 to 2010, this training grant has successfully completed training of 22 predoctoral students in the art of genomic analysis and interpretation. These doctorates have gone on to productive careers in genomic sciences in industry, government, and academia.

描述（由申请人提供）：将DNA测序技术中最近的量子LEAP收集的数据转换为有用的生物医学知识是21世纪最大的科学挑战之一。没有计算机，现在无法访问，操纵或分析的大量DNA数据。但是，最大的瓶颈涉及软件而不是硬件。尽管目前具有复杂水平，但我们仍然缺乏足够的理论和算法来以速度和精度执行许多基本任务和分子遗传学和遗传流行病学。这将需要一批新一代的科学家在生物学和数学科学中培训，以推动我们国家的基因组议程。很少有大学拥有基础设施和人力资源，可以在UCLA实施基因组分析培训计划。我们的培训计划的核心课程包括分子生物学，人类遗传学，概率和统计，生物信息学和生物医学伦理学的工作。学生还必须为每周的科学研讨会做准备并参加相关的科学研讨会。学员每月与计划教师和董事共同开会，以了解常规课程中未涵盖的职业事务。每年，我们都会在上半年的博士课程中优先培训12名专业学生。每个学员将获得两年的资金，取决于令人满意的进展。在特殊情况下，将考虑第三年的资金。这项培训补助金已将大学内四所学校和14个博士学位系的教师汇集在一起​​，以解决科学培训中当前的差距。在2002年至2010年期间，这项培训补助金已成功完成了对22名基因组分析和解释艺术中22名学生的培训。这些博士学位一直从事工业，政府和学术界基因组科学的生产力。