Interactions between adaptable pathogens, drugs and the human host

临床免疫学和生物医学统计中心（CCIBS）代表了皇家珀斯医院和默多克大学之间的合作，汇集了国际公认的临床免疫学、实验生物学和生物统计学和计算创新方面的专业知识。这些资源已应用于艾滋病毒和丙型肝炎疾病和治疗的广泛框架内的广泛研究问题。CCIBS已成为国际领先的卓越研究中心，在宿主-病毒相互作用的创新方法方面建立了声誉，这些方法建立在对人类和病毒基因组的群体遗传学研究的悠久传统之上，并结合了协商复杂计算和统计挑战的意愿，以便忠实地反映群体水平上的动态生物过程。早期认识到遗传和临床数据的大型和集成存储库是基因组时代研究成功的基础，这也导致了世界上最全面的艾滋病毒基因测序数据存储库的创建。CCIBS在几个不同的研究领域做出的贡献，包括了解病毒对宿主免疫反应的适应，预测药物超敏反应的基因测试的发展，以及抗逆转录病毒药物相关毒性的原因，已发表在著名期刊上，包括科学，自然，自然免疫学，柳叶刀，美国国家科学院院刊和美国人类遗传学杂志。并且还促成了许多国际合作，这些合作认识到CCIBS能够为旨在了解艾滋病毒和丙型肝炎生物学和治疗基本方面的全球研究工作带来独特的属性。

The Centre for Clinical Immunology and Biomedical Statistics (CCIBS) represents a collaboration between Royal Perth Hospital and Murdoch University that has brought together internationally recognised expertise in clinical immunology, experimental biology and innovation in biostatistics and computing. These resources have been applied to a broad range of research issues within the broad framework of HIV and hepatitis C disease and treatment. CCIBS has become a leading centre of research excellence internationally, establishing a reputation for innovative approaches to host-viral interactions that are built on a long tradition of research into the population genetics of both human and viral genomes, combined with a willingness to negotiate complex computation and statistical challenges in order to faithfully reflect dynamic biological processes at a population level. An early recognition that large and integrated repositories of genetic and clinical data are fundamental to the research success in the genomic era has also led to the creation of the single most comprehensive repository of HIV genetic sequencing data in the world. The contributions that CCIBS has made to several distinct areas of research, including understanding viral adaptation to host immune responses, the development of genetic testing to predict drug hypersensitivity reactions, and causes of antiretroviral drug-associated toxicities, have been published in prestigious journals including Science, Nature, Nature Immunology, The Lancet, Proceedings of National Academy of Sciences, and The American Journal of Human Genetics, and have also resulted in numerous international collaborations that recognise the unique attributes that CCIBS has been able to bring to the global research effort aimed at understanding fundamental aspects of HIV and hepatitis C biology and treatment.