Understanding pathogen effects on human T cell receptor diversity and function

点击翻译按钮获取中文摘要

HIV diversity observed at the global level is mostly due to the selection pressure exerted on the virus by our adaptive immune response. This process is important in determining infection outcome. This proposal will use a unique single cell approach to understand this complex host-viral interaction to identify important correlates of immune efficacy against HIV that will aid in the rational design of potential vaccine candidates and addresses a fundamental concept in anti-viral immunity.