Characterisation of polymorphism in HIV-1 sequence: investigation of viral escape from HLA-restricted immune responses

HIV-1 序列多态性的表征：研究病毒逃离 HLA 限制性免疫反应

• 批准号: nhmrc : 237412
• 负责人: A/Pr Mina John
• 金额: $ 28.36万
• 依托单位: Murdoch University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-polymorphism-hiv-immune-responses/76538
• 关键词: Characterisation; polymorphism; HIV; sequence; investigation

Although drug therapy has been developed for treatment of HIV infection, there are many aspects of optimal long-term therapy that are problematic. An important reason for this is that HIV disease is different in different individuals, and we believe this is in large part attributable to the way in which the virus can escape an individual's unique immune responses against it. HIV has been shown to escape by mutating and evolving during infection, but the nature and extent to which this occurs in everyone is not established. This is an important barrier to the design of effective vaccines against HIV. This study uses a novel method to describe the ways that HIV evolves uniquely in every individual, and to determine how this information relates to subsequent disease severity, response to therapy and response to vaccination. This will allow HIV infected patients to have better 'individualised' therapy as well as help in the design of effective vaccines.

虽然药物治疗已经被开发用于治疗HIV感染，但最佳长期治疗的许多方面都存在问题。一个重要的原因是，艾滋病毒在不同的个体中是不同的，我们认为这在很大程度上是由于病毒可以逃脱个体独特的免疫反应。艾滋病毒已被证明在感染期间通过突变和进化而逃逸，但这种情况在每个人身上发生的性质和程度尚不确定。这是设计有效的艾滋病毒疫苗的一个重要障碍。这项研究使用了一种新颖的方法来描述HIV在每个个体中独特的进化方式，并确定这些信息与随后的疾病严重程度、对治疗的反应和对疫苗接种的反应之间的关系。这将使艾滋病毒感染者获得更好的“个体化”治疗，并有助于设计有效的疫苗。