Mortality in a community sample of adults with arthritis

项目摘要 这项辅助提案的目标是约翰斯顿县骨关节炎（JoCo OA） 项目：关节炎和残疾（1U 01 DP 003206 -01 -由CDC资助）是为了创建一个 参与者在其生命周期中的增强生命状态、日期和死亡原因的存储库 目前的随访，并检查膝关节和/或髋关节OA对死亡率的贡献， 非西班牙裔非洲裔美国人（AA）和白人男性和女性。母研究 旨在涵盖OA过程的多个方面， 从临床前到残疾。研究这个队列的死亡率 长达25年的观察和广泛的OA和慢性疾病数据， 多个时间点提供了完美的机会来回答这些问题， 其他研究不能，此外，加强母项目。我们的目标是 完成这三个具体目标和第四个探索性目标：1）创建一个 JoCo OA 20年以上随访中增强的生命状态数据库， 死亡日期和原因; 2）确定基线时膝关节和/或髋关节OA是否 与过高的全因或特定疾病死亡率相关，独立于 伴随的合并症和肥胖，以及是否按性别单独改变， 按种族和社会经济地位; 3）评估OA的综合影响， 肥胖、糖尿病或心血管疾病的全因和疾病特异性 死亡率;以及4）探讨OA的严重程度和OA症状的持续性 影响全因死亡率和特定疾病死亡率。

Project Abstract The goal of this ancillary proposal to the Johnston County Osteoarthritis (JoCo OA) Project: Arthritis and Disability (1U01DP003206-01 - funded by the CDC) is to create a repository of enhanced vital status, date and cause of death for participants during their current follow-up and to examine the contribution of knee and/or hip OA to mortality in non-Hispanic African-American (AA) and Caucasian men and women. The parent study was designed to encompass multiple aspects of the OA process from the biomedical to the psychosocial and from the pre-clinical to disability. Examining mortality in this cohort with up to 25 years of observation and extensive OA and chronic conditions data over multiple time points provides the perfect opportunity to answer these questions in ways other studies could not, and additionally, enhance the parent project. The goal will be accomplished with these 3 specific aims and a 4th exploratory aim: 1) to create a repository of enhanced vital status data in the 20+ year follow-up of the JoCo OA with the date and cause of death; 2) to determine whether knee and/or hip OA at baseline is associated with excess all-cause or disease-specific mortality, independent of concomitant comorbidities and obesity, and whether it is modified separately by gender, by race, and by socioeconomic status; 3) to evaluate the combined impact of OA and obesity, diabetes mellitus or cardiovascular disease on all-cause and disease specific mortality; and 4) to explore whether OA severity and persistence of symptoms of OA impacts all-cause and disease-specific mortality.