Mortality in a community sample of adults with arthritis

项目摘要 约翰斯顿县骨关节炎 (JoCo OA) 辅助提案的目标 项目：关节炎与残疾（1U01DP003206-01 - 由 CDC 资助）旨在创建一个 参与者在其期间的增强生命状态、死亡日期和原因的存储库 目前的随访并检查膝关节和/或髋关节 OA 对死亡率的影响 非西班牙裔非裔美国人 (AA) 和白人男性和女性。家长学习 旨在涵盖 OA 流程的多个方面，从生物医学到 心理社会，从临床前到残疾。检查该队列的死亡率 拥有长达 25 年的观察以及广泛的 OA 和慢性病数据 多个时间点提供了以多种方式回答这些问题的绝佳机会 另外，其他研究无法增强母项目。目标将是 实现了这 3 个具体目标和第四个探索性目标：1）创建 JoCo OA 20 年后续行动中增强的生命状态数据存储库 死亡日期和原因； 2) 确定基线时膝关节和/或髋关节 OA 是否为 与过度的全因或疾病特异性死亡率相关，独立于 伴随的合并症和肥胖，以及是否按性别单独修改， 按种族和社会经济地位； 3) 评估 OA 的综合影响 全因和特定疾病的肥胖、糖尿病或心血管疾病 死亡率； 4) 探讨 OA 的严重程度和 OA 症状的持续性 影响全因死亡率和特定疾病死亡率。

Project Abstract The goal of this ancillary proposal to the Johnston County Osteoarthritis (JoCo OA) Project: Arthritis and Disability (1U01DP003206-01 - funded by the CDC) is to create a repository of enhanced vital status, date and cause of death for participants during their current follow-up and to examine the contribution of knee and/or hip OA to mortality in non-Hispanic African-American (AA) and Caucasian men and women. The parent study was designed to encompass multiple aspects of the OA process from the biomedical to the psychosocial and from the pre-clinical to disability. Examining mortality in this cohort with up to 25 years of observation and extensive OA and chronic conditions data over multiple time points provides the perfect opportunity to answer these questions in ways other studies could not, and additionally, enhance the parent project. The goal will be accomplished with these 3 specific aims and a 4th exploratory aim: 1) to create a repository of enhanced vital status data in the 20+ year follow-up of the JoCo OA with the date and cause of death; 2) to determine whether knee and/or hip OA at baseline is associated with excess all-cause or disease-specific mortality, independent of concomitant comorbidities and obesity, and whether it is modified separately by gender, by race, and by socioeconomic status; 3) to evaluate the combined impact of OA and obesity, diabetes mellitus or cardiovascular disease on all-cause and disease specific mortality; and 4) to explore whether OA severity and persistence of symptoms of OA impacts all-cause and disease-specific mortality.