Mortality in a community sample of adults with arthritis

成人关节炎患者社区样本的死亡率

• 批准号: 8735617
• 负责人: LEIGH Fleming CALLAHAN
• 金额: $ 26.33万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-16 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735617
• 关键词: Adult; Affect; African American; Arthritis; Cardiovascular Diseases; Caring; Caucasians; Caucasoid Race; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chronic; Clinical; Communities; Comorbidity; County; Data; Degenerative polyarthritis; Diabetes Mellitus; Disease; Funding; Future; Gender; General Population; Goals; Health; Hip Osteoarthritis; Individual; Kidney Diseases; Knee; Measures; Mediating; Modeling; Morbidity - disease rate; Musculoskeletal Diseases; Not Hispanic or Latino; Obesity; Obesity associated cancer; Obesity associated cardiovascular disease; Operative Surgical Procedures; Pain; Parents; Participant; Patients; Physical activity; Policy Developments; Population; Prevalence; Process; Public Health; Quality of life; Quality-Adjusted Life Years; Race; Risk Factors; Sampling; Severities; Socioeconomic Status; Source; Symptoms; Time; United States National Center for Health Statistics; Visit; Vital Status; Woman; aged; attributable mortality; cohort; comparison group; design; disability; follow-up; indexing; low socioeconomic status; men; mortality; novel; parent project; population based; pre-clinical; prospective; psychosocial; public health relevance; repository

DESCRIPTION (provided by applicant): The goal of this ancillary proposal to the Johnston County Osteoarthritis (JoCo OA) Project: Arthritis and Disability (1U01DP003206-01 - funded by the CDC) is to create a repository of enhanced vital status, date and cause of death for participants during their current follow-up and to examine the contribution of knee and/or hip OA to mortality in non-Hispanic African-American (AA) and Caucasian men and women. The parent study was designed to encompass multiple aspects of the OA process from the biomedical to the psychosocial and from the pre-clinical to disability. Examining mortality in this cohort with u to 25 years of observation and extensive OA and chronic conditions data over multiple time points provides the perfect opportunity to answer these questions in ways other studies could not, and additionally, enhance the parent project. The goal will be accomplished with these 3 specific aims and a 4th exploratory aim: 1) to create a repository of enhanced vital status data in the 20+ year follow-up of the JoCo OA with the date and cause of death; 2) to determine whether knee and/or hip OA at baseline is associated with excess all-cause or disease-specific mortality, independent of concomitant comorbidities and obesity, and whether it is modified separately by gender, by race, and by socioeconomic status; 3) to evaluate the combined impact of OA and obesity, diabetes mellitus or cardiovascular disease on all-cause and disease specific mortality; and 4) to explore whether OA severity and persistence of symptoms of OA impacts all-cause and disease-specific mortality.

描述(由申请人提供)：约翰斯顿县骨关节炎(JoCo OA)项目：关节炎和残疾(1U01DP003206-01-由疾控中心资助)的这项辅助提案的目标是为参与者在当前的随访中创建一个增强的生命状态、日期和死亡原因的储存库，并检查膝盖和/或髋关节骨关节炎对非西班牙裔非裔美国人(AA)和高加索男性和女性死亡率的贡献。母体研究旨在涵盖从生物医学到心理社会以及从临床前到残疾的OA过程的多个方面。通过u到25年的观察和多个时间点的广泛的骨关节炎和慢性病数据来检验这个队列中的死亡率，提供了一个完美的机会来回答这些问题，这是其他研究无法做到的，此外，还可以增强母公司的项目。目标将通过以下3个具体目标和第4个探索性目标来实现：1)创建增强的生命状态数据存储库 JOCO OA的20年以上随访包括死亡日期和原因；2)确定基线水平的膝关节和/或髋关节OA是否与超额的全原因或特定疾病死亡率相关，独立于伴发的并发症和肥胖，以及是否按性别、种族和社会经济状况单独改变；3)评估OA与肥胖、糖尿病或心血管疾病对全原因和特定疾病死亡率的联合影响；4)探讨OA的严重程度和症状的持续性是否影响全原因和特定疾病的死亡率。