Mortality in a community sample of adults with arthritis

描述（由申请人提供）：本约翰斯顿县骨关节炎（JoCo OA）项目辅助建议书的目标：关节炎和残疾（1U 01 DP 003206 -01 -由CDC资助）是为了创建一个增强的生命状态存储库，当前随访期间受试者的死亡日期和原因，并检查膝关节和/或髋关节OA对非西班牙裔非洲人死亡率的影响-美国人（AA）和白人男性和女性。母研究旨在涵盖OA过程的多个方面，从生物医学到心理社会，从临床前到残疾。通过u至25年的观察和多个时间点的广泛OA和慢性疾病数据检查该队列的死亡率，为以其他研究无法回答的方式回答这些问题提供了绝佳的机会，此外，还增强了母项目。该目标将通过这三个具体目标和第四个探索性目标来实现：1）创建一个增强的生命状态数据库， JoCo OA的20年以上随访，包括死亡日期和原因; 2）确定基线时膝关节和/或髋关节OA是否与过度的全因或疾病特异性死亡率相关，与合并症和肥胖无关，以及是否按性别、种族和社会经济地位分别进行修改; 3）评估OA和肥胖、糖尿病或心血管疾病对全因和疾病特异性死亡率的联合影响;以及4）探索OA严重程度和OA症状的持续性是否影响全因和疾病特异性死亡率。

DESCRIPTION (provided by applicant): The goal of this ancillary proposal to the Johnston County Osteoarthritis (JoCo OA) Project: Arthritis and Disability (1U01DP003206-01 - funded by the CDC) is to create a repository of enhanced vital status, date and cause of death for participants during their current follow-up and to examine the contribution of knee and/or hip OA to mortality in non-Hispanic African-American (AA) and Caucasian men and women. The parent study was designed to encompass multiple aspects of the OA process from the biomedical to the psychosocial and from the pre-clinical to disability. Examining mortality in this cohort with u to 25 years of observation and extensive OA and chronic conditions data over multiple time points provides the perfect opportunity to answer these questions in ways other studies could not, and additionally, enhance the parent project. The goal will be accomplished with these 3 specific aims and a 4th exploratory aim: 1) to create a repository of enhanced vital status data in the 20+ year follow-up of the JoCo OA with the date and cause of death; 2) to determine whether knee and/or hip OA at baseline is associated with excess all-cause or disease-specific mortality, independent of concomitant comorbidities and obesity, and whether it is modified separately by gender, by race, and by socioeconomic status; 3) to evaluate the combined impact of OA and obesity, diabetes mellitus or cardiovascular disease on all-cause and disease specific mortality; and 4) to explore whether OA severity and persistence of symptoms of OA impacts all-cause and disease-specific mortality.