Center for Biomolecular Structure and Dynamics

生物分子结构与动力学中心

• 批准号: 8730685
• 负责人: Stephen R Sprang
• 金额: $ 198.2万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8730685
• 关键词: Address; Adenylate Cyclase; Amino Acids; Arenavirus; Binding Sites; Biochemical; Biochemistry; Biological; Biological Sciences; Biology; Biophysics; Catabolism; Catalysis; Cells; Centers of Research Excellence; Chemicals; Chemistry; Collaborations; Core Facility; Dioxygenases; Enzymes; Esapent; Faculty; Floor; Foundations; Funding; Glycoproteins; Goals; Homology Modeling; Human; Infection; Interdisciplinary Study; Investigation; Junin virus; Ligand Binding; Ligands; Magnetism; Mediating; Membrane Fusion; Membrane Proteins; Mental disorders; Mentors; Mentorship; Metabolism; Methods; Molecular; Molecular Computations; Molecular Machines; Molecular Structure; Montana; Multi-Drug Resistance; Nuclear; Opioid Receptor; Perception; Pharmacologic Substance; Physiology; Plant Roots; Positioning Attribute; Property; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Science; Self Assessment; Signal Transduction; Spectrum Analysis; Structure; System; Tertiary Protein Structure; Theoretical Biology; Tryptophan; Universities; Viral; Viral Proteins; Vision; X ray diffraction analysis; X-Ray Crystallography; X-Ray Diffraction; base; chemical genetics; computational chemistry; design; empowered; enzyme mechanism; human disease; indoleamine; infrastructure development; innovation; interest; member; molecular dynamics; multidisciplinary; programs; protein complex; quantum chemistry; research facility; research study; structural biology

The Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana (UM) is rooted in structural biology but multidisciplinary in scope. The rationale that underlies this program is based on the perception that effective biomedical innovation is driven from an understanding of macromolecular structure, which in turn, must be grounded on principles of experimental and theoretical chemistry. CBSD faculty are drawn from Department of Chemistry & Biochemistry, the Division of Biological Science and the Department of Biomedical and Pharmaceutical Sciences. Among this group are CBSD faculty with expertise in spectroscopy, structural biology, biochemistry and mechanistic and theoretical chemistry. We build on a strong foundation of sustained institutional support. Associated with the CBSD is a newly established interdisciplinary graduate program in Biochemistry and Biophysics. The goal of the proposed COBRE is to integrate investigators with research interests in cell and molecular physiology, mechanistic biochemistry, chemical biology, and theoretical and computational chemistry, into an interactive and collaborative network. With the creation of a CBSD COBRE, it is our goal to give structure to this vision by implementing the four aims of this proposal: Aim 1. Provide research support for five interdisciplinary research projects within the COBRE theme. These projects use theoretical and physical chemical methods to elucidate the catalytic mechanisms of enzymes involved in signal transduction and tryptophan catabolism. Structure-based homology modeling and chemical biology approaches will be used to design new ligands for the opioid receptor and to characterize the binding sites of the multidrug resistance transporter. Heteronuclear NMR experiments will be used to elucidate the structures of critical domains in the Junin arenavirus membrane fusion glycoprotein. Aim 2 shall be to recruit two new faculty members to CBSD-affiliated departments to build on existing strengths and introduce new expertise within the CBSD. Aim 3 will support collaborative activities involving CBSD faculty by sustaining of critical core research facilities in Macromolecular X-ray diffraction, Macromolecular NMR, BioSpectroscopy and Molecular Computation. Aim 4 will establish a supportive program to sustain an intellectually vibrant and cohesive CBSD that promotes infrastructure development, mentoring, scientific exchange and collaboration, with a robust advisory and self-assessment structure.

蒙大拿州大学（UM）的生物分子结构与动力学中心（CBSD）植根于结构生物学，但范围涉及多学科。该计划的基本原理是基于这样一种认识，即有效的生物医学创新是由对大分子结构的理解驱动的，而大分子结构又必须以实验和理论化学原理为基础。教职员工来自化学与生物化学系、生物科学系和生物医学与制药科学系。在这个群体中，CBSD的教师在光谱学，结构生物学，生物化学以及机械和理论化学方面具有专业知识。我们建立在持续的机构支持的坚实基础上。与CBSD相关的是一个新建立的生物化学和生物物理学跨学科研究生课程。拟议的COBRE的目标是将研究人员与细胞和分子生理学，机械生物化学，化学生物学，理论和计算化学的研究兴趣整合到一个互动和协作的网络中。随着CBSD COBRE的建立，我们的目标是通过实施本提案的四个目标来构建这一愿景：