Biomolecular Structure and Dynamics

加州大学生物分子结构与动力学生物医学研究中心 蒙大拿州(CBSD Cobre)支持应用生物物理学、结构物理学、 生物学和化学，以了解健康和疾病中生物过程的机制基础。 CBSD的教员来自人文学院和生物医学学院的基础和生物医学科学 理工学院和健康职业与生物医学学院。以中心为代表的学科 学院包括细胞生物学、药理学、神经生物学、生物化学、合成化学和 化学和生物学中的计算研究。CBSD Cobre计划第二阶段的第一个目标是 支持和指导CBSD调查人员：a)支持四名初级项目调查人员，他们将进行 研究调节或模拟蛋白质受体和酶的小分子的一般主题；b) 实施有效而有力的指导计划，引导初级调查人员走上 学术成就和独立资助；c)在以下方面确定和支持强有力的替代项目 CBSD研究主题，邀请现有的调查人员和合作项目来加强 中心的研究凝聚力；以及d)维持试点项目和过渡资助方案，以鼓励 创新的探索性研究，并在追求独立资金的同时支持富有成效的研究人员。 该提案的目标2是继续第一阶段的工作，以建立一支强大的CBSD调查队伍 战略性教师招聘，由职业发展奖支持，强调结构和 生物过程中大分子组装的动力学。目标3推进了核心设施结构 CBSD通过：a)维持一个强大的行政核心，提供有效的领导、监督和 中心的财务管理；b)发展更多的大分子X射线衍射能力 进行蛋白质表达和纯化以及小分子X射线结晶学的核心设施；c) 发展生物光谱核心研究实验室在时间分辨方面的先进能力 荧光光谱学，包括单分子分析，以及d)巩固综合协作 分子计算核心设施中的蛋白质建模和分子与动力学设施。目标4： 应用程序是为了进行一系列的程序性活动，以促进程序的凝聚力和科学性 太棒了。这项提议的一个重要的总体目标是通过指导和 支持一个由优秀的初级和老牌调查人员组成的社区，并通过采用多重资助 STREAMS以确保核心研究设施的可持续性。

The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics at the University of Montana (CBSD COBRE) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. CBSD faculty members are drawn from the basic and biomedical sciences in the Colleges of Humanities and Sciences and the College of Health Professions and Biomedical Sciences. Disciplines represented by Center faculty include cellular biology, pharmacology, neurobiology, biochemistry, synthetic chemistry and computational research in chemistry and biology. The first aim of the Phase II CBSD COBRE program is to support and mentor CBSD Investigators by: a) supporting four Junior Project Investigators who will conduct research in the general theme of small molecules that regulate or mimic protein receptors and enzymes; b) conducting an effective and robust mentoring program to guide Junior Investigators along the path towards academic success and independent funding; c) identifying and supporting strong replacement projects within the CBSD research theme, inviting both established investigators and collaborative projects to strengthen the research cohesion of the Center; and d) maintaining a Pilot Project and Bridge-funding Program to encourage innovative explorative research and sustain productive Investigators while they pursue independent funding. Aim 2 of the proposal is to carry on the work of Phase I to build a strong cohort of CBSD investigators though strategic faculty recruitment, supported by Career Development Awards, emphasizing the structure and dynamics of macromolecular assemblies in biological processes. Aim 3 advances the Core Facility structure of the CBSD by: a) maintaining a strong Administrative Core that provides effective leadership, oversight and financial management of the Center; b) developing additional capability in the Macromolecular X-ray Diffraction Core Facility to conduct protein expression and purification, as well as small molecule X-ray crystallography; c) developing advanced capabilities in the BioSpectroscopy Core Research Laboratory in time-resolved fluorescence spectroscopy, including single molecule analysis, and d) consolidating an integrated collaborative facility for protein modeling and molecular and dynamics in the Molecular Computation Core Facility. Aim 4 of the application is to conduct an array of programmatic activities to promote program cohesion and scientific excellence. An important overall goal of this proposal is to foster a self-sustainable Center by mentoring and supporting a community of outstanding junior and established investigators, and by adopting multiple funding streams to ensure sustainable Core Research Facilities.