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NOVEL APPROACAHES FOR IMPROVING PEDIATRIC BRAFV600E GLIOMA PATIENT OUTCOMES

NOVEL APPROACAHES FOR IMPROVING PEDIATRIC BRAFV600E GLIOMA PATIENT OUTCOMES
改善儿科 BRAFV600E 胶质瘤患者预后的新方法
批准号:
8514312
负责人:
Charles David James
金额:
$27.15万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-05-01 至 2018-08-31

项目摘要

项目成果

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中文摘要
翻译
神经胶质瘤是侵袭性脑肿瘤,影响儿童。目前对高级别胶质瘤的治疗,大多数通常包括手术、放疗和细胞毒化疗,仅将受累儿童的中位生存期延长至14个月,并导致显著的发病率。不能完全切除的低级别胶质瘤通常在化疗方法失败后用放射治疗,这会导致显著的神经认知和发育风险。该项目针对一种特定的癌基因改变,BRAF发生在多达14%的儿童高级别胶质瘤中。对于某些亚型的儿童胶质瘤,BRAF的频率要高得多(多形性黄色星形细胞瘤为66%)。针对BRAF^(R)的抑制剂已经被开发出来,并对含有这种突变的黑色素瘤显示出显著的疗效。一种这样的抑制剂vemurafenib现在已经被FDA批准用于黑色素瘤,并且正在研究用于治疗许多其他BRAF^(R)
英文摘要
instnjctions):Gliomas are aggressive brain tumors that affect children. Current treatment of high-grade glioma, most ofteninvolving surgery, radiation, and cytotoxic chemotherapy, only extend median survival of affected children to14 months, and results in significant morbidity. Low-grade glioma, that cannot be completely resected aretreated with radiation, typically after failure of chemotherapy approaches, with significant resulting neuro-cognitive and developmental risks. This project addresses a specific oncogene alteration, BRAF^^¿^occurring in as many as 14% of pediatric high-grade glioma. For certain subtypes of pediatric glioma thefrequency of BRAF''^¿¿^ is much higher (66% in pleomorphic xanthoastrocytoma). Inhibitors that specificallytarget BRAF^(R)¿¿^ have been developed and have shown remarkable efficacy against melanomas that harborthis mutation. One such inhibitor, vemurafenib, has now been FDA-approved for melanoma, and is underinvestigation for treating a number of other BRAF^(R)
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SLFN5: A Novel Therapeutic Target for Glioblastoma
  • 批准号:
    10240565
  • 项目类别:
  • 资助金额:
    $34.56万
  • 财政年份:
    2019
  • 负责人:
    Charles David James
  • 依托单位:
SLFN5: A Novel Therapeutic Target for Glioblastoma
  • 批准号:
    10468276
  • 项目类别:
  • 资助金额:
    $34.56万
  • 财政年份:
    2019
  • 负责人:
    Charles David James
  • 依托单位:
Career Enhancement Program
Career Enhancement Program
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