新颖的 APCI 源-猫眼课题宝

新颖的 APCI 源

批准号：

8715083

负责人：

EUGENE MOSKOVETS

金额：

$16.49万

依托单位：

MASSTECH, INC.

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-08-01 至 2016-01-31

来源：

https://reporter.nih.gov/project-details/8715083

关键词：

Air Antibiotics Area Atmospheric Pressure Biological Blood capillaries Charge Chemicals Complex Detection Disadvantaged Disease Drug-sensitive Electrodes Electrons Exhibits Figs - dietary Filament Frequencies Gases Goals Heating Intake Ions Life Lipids Mass Spectrum Analysis Methods Metric Molecular Monitor Nature Nebulizer Optics Performance Pharmaceutical Preparations Phase Physiologic pulse Plasma Pulse Rates Reagent Relative (related person)Sampling Sensitivity and Specificity Series Small Business Innovation Research Grant Solvents Source Specificity Speed Steroids Stream Surface System Techniques Testing Time United States National Institutes of Health Water Work analytical tool atmospheric conditions base capillary cold temperature design electric field improved instrument ion source ionization ionization technique mass spectrometer nanosecond novel planetary Atmosphere prevent public health relevance tandem mass spectrometry vapor voltage

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DESCRIPTION (provided by applicant): Significant increase in the efficiency and speed of atmospheric pressure chemical ionization (APCI) in tandem mass spectrometry (MS/MS) will have a profound impact on its applications to the entire analytical field of characterization of drugs, metabolites, lipids, steroids, etc. A broad applicability of APCI-based MS analysis makes it a unique analytical tool specifically targeting trace amounts of many chemical and biological substances. We plan to build a novel APCI ion source based on atmospheric dielectric barrier discharge (DBD) to significantly improve efficiency and specificity of ACPI-MS based detection method.

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