South Carolina Research Center for Recovery from Stroke

描述(由申请人提供)：南卡罗来纳州中风康复研究中心(SCRCRS)的总体目标是使中风康复方面的杰出多学科合作研究成为可能。中风对南卡罗来纳州具有独特的重要性，因为不成比例的发病率导致中风后残疾造成不适当的经济/社会负担。我们的组织理念是，更好地理解神经可塑性的经验依赖性本质将使我们能够研究和利用固有的神经恢复过程，开发和转化基于机制的新型干预策略，并最终改善中风康复者的功能和生活质量。其具体目标是：1)培养和指导一支精通多个领域的初级科学家队伍；2)开发创新的科学核心资源，旨在推动动物和人类研究中的中风恢复研究；以及3)通过开发多学科转换研究计划以及严格的评估和改进策略，促进SCRCRS的长期生存能力。 该中心由一个由一名博士生物医学工程师/生物力学科学家和一名医学博士/临床中风专家组成的多学科团队领导，汇集了医学院和相关健康科学学院的资源和学科。科学核心包括量化行为评估和康复核心，以提供标准化经验和行为和功能的定量测量；脑刺激核心，为治疗和可塑性及神经生理学的定量测量提供可塑性修改佐剂；神经成像核心，以提供可塑性以及结构和功能连接的定量测量；以及临床和翻译工具及资源核心，以通过与MUSC CTSA的强大接口，促进开发可查询的、安全的卒中临床注册数据库。所有初级调查员(JLS)将调查中风康复的某些方面，最初的重点是上肢功能、运动和缓解抑郁， 使用一套在中风康复研究环境中很少找到的测量工具。 该中心的创新特色包括核心领导者和JLS的跨专业和多学科专业知识；集成了运动捕捉和临床评估工具、脑刺激工具、神经成像工具，以及应用于中风康复研究的生物统计和患者记录管理资源；以及一种新颖的“多来源指导”方法，使JLS成为中风康复临床和翻译研究的未来领导者。广泛的机构支持-包括灵活的资金、新教师招聘和资本改善-将为中心的长期成功和生存能力提供保障。

DESCRIPTION (provided by applicant): The overall goal of the South Carolina Research Center for Recovery from Stroke (SCRCRS) is to enable outstanding multidisciplinary collaborative research in recovery from stroke. Stroke is of unique importance to South Carolina as a disproportionate rate of incidence results in undue economic/social burdens from post-stroke disability. Our organizing concept is that better understanding of the experience-dependent nature of neural plasticity will allow us to investigate and exploit inherent neural recovery processes, develop and translate novel mechanism- based interventional strategies, and ultimately improve the function and quality of life of individuals recovering from stroke. The specific aims are to: 1) train and mentor a cadre of junior scientists who are skilled in multiple domains; 2) develop innovative scientific core resources designed to advance stroke recovery research in animal and human studies; and 3) promote the long-term viability of the SCRCRS through development of multidisciplinary translational research programs and rigorous evaluation and improvement strategies. The Center is led by a multidisciplinary team, comprised of a PhD biomedical engineer/biomechanical scientist and an MD/clinical stroke expert, coalescing resources and disciplines from schools of medicine and allied health sciences. Scientific cores include the Quantitative Behavioral Assessment and Rehabilitation Core to provide standardized experience and quantitative measurement of behavior and function; Brain Stimulation Core to provide a plasticity modifying adjuvant for treatment and quantitative measurement of plasticity and neurophysiology; Neuroimaging Core to provide quantitative measurement of plasticity and structural and functional connectivity; and Clinical & Translational Tools and Resources Core to facilitate the development of a queriable, secure Stroke Clinical Registry Database via a robust interface with MUSC's CTSA. All Junior Investigators (Jls) will investigate some aspect of stroke recovery, with initial focus on upper extremity function, locomotion and alleviation of depression, using a suite of measurement tools rarely found in stroke recovery research settings. Innovative features of the Center include the interprofessional and multidisciplinary expertise of core leaders and Jls; the integration of motion capture and clinical assessment tools, brain stimulation tools, neuroimaging tools, and resources for biostatistics and patient record management applied to stroke recovery research; and a novel 'multiple source mentoring' approach to prepare the Jls as future leaders in clinical and translational research in recovery from stroke. Extensive institutional support - including flexible funds, new faculty recruitment an capital Improvements - will underwrite the Center's long-term success and viability.