National Center of Neuromodulation for Rehabilitation (NC NM4R)

 描述(由申请人提供)：我们提出了一个名为国家神经调制康复中心(NC NM4R)的医疗康复研究基础设施计划，该计划将成为研究人员使用NM4R令人兴奋的工具来开发下一代康复干预措施以及了解和研究与康复相关的神经再生神经系统变化的全国性资源。该中心在非侵入性脑刺激(Mark George博士)、康复(Steve Kautz和Rick Segal博士)、脑和脊髓网络的操作性调节(Aiko Thompson博士和Jon Wolpaw博士)以及NM4R动物模型(Deanna Adkins博士)方面拥有卓越的专业知识。MUSC现有的特殊资源将支持该中心，包括许多直接相关的核心资源，支持与NIH/NIGMS中风康复生物医学研究卓越中心(COBRE)相关的神经康复研究，以及使MUSC(在George博士的领导下)成为世界上第一个通过功能磁共振成像对TMS进行扫描的机构。MUSC丰富的NM4R研究组合为外部研究人员提供了强大的合作机会。最重要的目标是努力 对NM4R研究领域的持续、强大的影响-脑刺激的机制和使用，以及脑和脊髓网络的可操作性调节与康复原则相结合。我们寻求通过翻译活动和编程来实现这一目标。目标1.通过讲习班、高级实践培训和与南加州大学实验室的磋商以及研究技能和资助力方面的指导，对NM4R研究人员进行培训。目标2.通过网络研讨会、国家/国际会议和专门的NM4R会议，为NM4R提供科学规划。所有可能的材料都将与技术简报和其他内容一起存档在我们的网站上。目的3.在NM4R中发展一个研究社区，作为一个积极的催化剂，凝聚一个分享想法、广泛合作并为制定该领域未来目标做出贡献的互动社区。目标4.通过以下方式推进NM4R领域：(A)赞助一项重点技术开发方案，该方案将完善在讲习班和其他论坛上公布的材料，并继续开发和推进NM4R方法，特别是关键的翻译研究所需的方法；以及(B)提供利用人类和/或动物的同行评议的试点项目 模特们。重要的是，NM4R是一项可传授的专业知识--MUSC拥有向世界出口的成熟历史，并将在国家中心进一步发展。我们将使用广泛的评估和反馈来最好地确保NC NM4R的迭代和相关发展。

 DESCRIPTION (provided by applicant): We propose a medical rehabilitation research infrastructure program called the National Center of Neuromodulation for Rehabilitation (NC NM4R) that will be a national resource for researchers using the exciting tools of NM4R to develop the next generation of rehabilitation interventions and to understand and study neuroplastic nervous system changes associated with rehabilitation. The center builds on outstanding expertise in non-invasive brain stimulation (Dr. Mark George), rehabilitation (Drs. Steve Kautz and Rick Segal), operant conditioning of brain and spinal networks (Drs. Aiko Thompson and Jon Wolpaw), and animal models of NM4R (Dr. DeAnna Adkins). Exceptional resources already in place at MUSC will support the center, including a number of directly relevant core resources supporting neurorehabilitation research associated with an NIH/NIGMS Center of Biomedical Research Excellence (COBRE) in Stroke Recovery and the specially designed equipment that enabled MUSC (under Dr. George) to become the first institution in the world to image TMS in the scanner with fMRI. A rich portfolio of NM4R research at MUSC offers robust opportunities for collaboration for external investigators. The overarching goal is to exert a sustained, powerful influence on the research field of NM4R - the mechanisms and use of brain stimulation and operant conditioning of brain and spinal cord networks integrated with rehabilitation principles. We seek to fulfill that goal through translational activities and programming. Aim 1. Train researchers in NM4R through workshops, advanced hands-on training and consultations with MUSC laboratories and mentorship in research skills and grantsmanship. Aim 2. Provide scientific programming in NM4R through webinars, national/international conference sessions, and specialized NM4R conferences. All material possible will be archived on our website along with technical briefs and other content. Aim 3. Develop a research community in NM4R by being an active catalyst to coalesce an interactive community that shares ideas, collaborates extensively and contributes to setting future goals for the field. Aim 4. Advance the field of NM4R by (a) sponsoring a focused technical development program that will refine material for promulgation in the workshops and other forums and continue to develop and advance NM4R methods, particularly those needed in critical translational studies, and (b) offering peer-reviewed pilot projects utilizing human and/or animal models. Importantly, NM4R is a teachable expertise - one that MUSC has a proven history of exporting to the world and will build upon in the National Center. We will use extensive evaluation and feedback to best assure the iterative and relevant evolution of the NC NM4R.