National Center of Neuromodulation for Rehabilitation (NC NM4R)

国家康复神经调节中心 (NC NM4R)

• 批准号: 9750479
• 负责人: STEVEN A. KAUTZ
• 金额: $ 10.52万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750479
• 关键词: Animal Model; Archives; Brain; Centers of Research Excellence; Collaborations; Communities; Consultations; Disease; Educational workshop; Ensure; Equipment Design; Evaluation; Evidence based treatment; Evolution; Expenditure; Feedback; Functional Magnetic Resonance Imaging; Future; Goals; Image; Injury; Institution; International; Intervention; Laboratories; Long-Term Care; Mental Depression; Mental disorders; Mentorship; Methods; Modality; Movement Disorders; National Institute of General Medical Sciences; Nervous system structure; Neurologic; Neuronal Plasticity; Neurorehabilitation; Operant Conditioning; Parkinson Disease; Peer Review; Pilot Projects; Postdoctoral Fellow; Program Development; Program Evaluation; Public Health; Quality of life; Recording of previous events; Rehabilitation therapy; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Resources; Site; Spinal; Spinal Cord; Spinal cord injury; Stroke; Technology; Time; Training; Translations; United States National Institutes of Health; Work; catalyst; clinical practice; flexibility; functional disability; human model; improved; innovative technologies; multidisciplinary; neural circuit; neuroregulation; next generation; programs; public health relevance; skills; stroke recovery; symposium; tool; translational study; web site; webinar

 DESCRIPTION (provided by applicant): We propose a medical rehabilitation research infrastructure program called the National Center of Neuromodulation for Rehabilitation (NC NM4R) that will be a national resource for researchers using the exciting tools of NM4R to develop the next generation of rehabilitation interventions and to understand and study neuroplastic nervous system changes associated with rehabilitation. The center builds on outstanding expertise in non-invasive brain stimulation (Dr. Mark George), rehabilitation (Drs. Steve Kautz and Rick Segal), operant conditioning of brain and spinal networks (Drs. Aiko Thompson and Jon Wolpaw), and animal models of NM4R (Dr. DeAnna Adkins). Exceptional resources already in place at MUSC will support the center, including a number of directly relevant core resources supporting neurorehabilitation research associated with an NIH/NIGMS Center of Biomedical Research Excellence (COBRE) in Stroke Recovery and the specially designed equipment that enabled MUSC (under Dr. George) to become the first institution in the world to image TMS in the scanner with fMRI. A rich portfolio of NM4R research at MUSC offers robust opportunities for collaboration for external investigators. The overarching goal is to exert a sustained, powerful influence on the research field of NM4R - the mechanisms and use of brain stimulation and operant conditioning of brain and spinal cord networks integrated with rehabilitation principles. We seek to fulfill that goal through translational activities and programming. Aim 1. Train researchers in NM4R through workshops, advanced hands-on training and consultations with MUSC laboratories and mentorship in research skills and grantsmanship. Aim 2. Provide scientific programming in NM4R through webinars, national/international conference sessions, and specialized NM4R conferences. All material possible will be archived on our website along with technical briefs and other content. Aim 3. Develop a research community in NM4R by being an active catalyst to coalesce an interactive community that shares ideas, collaborates extensively and contributes to setting future goals for the field. Aim 4. Advance the field of NM4R by (a) sponsoring a focused technical development program that will refine material for promulgation in the workshops and other forums and continue to develop and advance NM4R methods, particularly those needed in critical translational studies, and (b) offering peer-reviewed pilot projects utilizing human and/or animal models. Importantly, NM4R is a teachable expertise - one that MUSC has a proven history of exporting to the world and will build upon in the National Center. We will use extensive evaluation and feedback to best assure the iterative and relevant evolution of the NC NM4R.

 描述（由申请人提供）：我们提出了一个名为国家康复神经调节中心 (NC NM4R) 的医疗康复研究基础设施计划，该计划将成为研究人员使用 NM4R 令人兴奋的工具开发下一代康复干预措施并了解和研究与康复相关的神经可塑性神经系统变化的国家资源。该中心建立在非侵入性脑刺激（Mark George 博士）、康复（Steve Kautz 博士和 Rick Segal 博士）、大脑和脊柱网络操作调节（Aiko Thompson 和 Jon Wolpaw 博士）以及 NM4R 动物模型（DeAnna Adkins 博士）方面的杰出专业知识之上。 MUSC 已具备的卓越资源将为该中心提供支持，包括支持与 NIH/NIGMS 中风康复生物医学卓越研究中心 (COBRE) 相关的神经康复研究的许多直接相关核心资源，以及专门设计的设备，使 MUSC（乔治博士领导下）成为世界上第一个在扫描仪中使用功能磁共振成像对 TMS 进行成像的机构。 MUSC 丰富的 NM4R 研究组合为外部研究人员提供了良好的合作机会。总体目标是发挥 对 NM4R 研究领域产生了持续、强大的影响——脑刺激的机制和使用以及脑和脊髓网络的操作调节与康复原理相结合。我们寻求通过翻译活动和规划来实现这一目标。 目标 1. 通过研讨会、高级实践培训、与 MUSC 实验室的咨询以及研究技能和资助方面的指导，对 NM4R 的研究人员进行培训。 目标 2. 通过网络研讨会、国家/国际会议和专门的 NM4R 会议提供 NM4R 的科学规划。所有可能的材料将与技术简介和其他内容一起存档在我们的网站上。 目标 3. 通过积极推动 NM4R 发展研究社区，凝聚互动社区，分享想法、广泛合作，并为制定该领域的未来目标做出贡献。 目标 4. 通过以下方式推进 NM4R 领域：(a) 赞助一项重点技术开发计划，该计划将完善在研讨会和其他论坛上公布的材料，并继续开发和推进 NM4R 方法，特别是关键转化研究所需的方法，以及 (b) 提供利用人类和/或动物的同行评审试点项目 模型。重要的是，NM4R 是一种可传授的专业知识 - MUSC 拥有向世界输出的良好历史，并将在国家中心继续发展。我们将利用广泛的评估和反馈来最好地确保 NC NM4R 的迭代和相关发展。