National Center of Neuromodulation for Rehabilitation (NC NM4R)

国家康复神经调节中心 (NC NM4R)

• 批准号: 10155563
• 负责人: STEVEN A. KAUTZ
• 金额: $ 148.59万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10155563
• 关键词: Address; Affect; Alabama; Animal Model; Applications Grants; Area; Award; Behavior; Belief; Brain; Centers of Research Excellence; Childhood; Clinical; Clinical Research; Clinical Trials; Collaborations; Combined Modality Therapy; Communities; Consultations; Data; Data Collection; Development; Educational workshop; Ensure; Equipment Design; Evaluation; Evidence based intervention; Evidence based treatment; Exposure to; Extramural Activities; Failure; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Gender; Goals; Grant; Image; Infant; Institution; Intervention; Journals; Measurement; Medical; Mentors; Methods; Modeling; National Institute of General Medical Sciences; Nervous system structure; Neuronal Plasticity; Operant Conditioning; Paper; Peer Review; Physical Medicine; Population; Postdoctoral Fellow; Process; Psychiatry; Publishing; Rehabilitation therapy; Reproducibility; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Resources; Site; South Carolina; Spinal; Standardization; System; Techniques; Technology; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; Work; base; career; cohesion; design; ethnic diversity; evidence base; improved; insight; multidisciplinary; network models; neural circuit; neuroregulation; next generation; novel; programs; racial and ethnic; rehabilitation research; skills; stroke recovery; success; technology development; tool

OVERALL – PROJECT SUMMARY / ABSTRACT Rehabilitation crucially requires interaction with the nervous system. Thus, neuromodulation (NM) is a tool uniquely able to address a large number of conditions and populations through a set of common principles that underlie an emerging neural circuit-based approach to rehabilitation and medicine. Our foundational belief is that applying NM to specific networks offers outstanding promise for advancing and improving nearly all fields of rehabilitation. While having grown over the past five years, the field of NM for rehabilitation (NM4R – the combination of NM and rehabilitation) is still nascent and is just beginning to clinically impact the practice of rehabilitation. The renewal of the National Center of Neuromodulation for Rehabilitation (NC NM4R) at the Medical University of South Carolina (MUSC) builds upon our early successes to facilitate the key steps in the discovery process that are required to develop the next generation of NM4R interventions and to use these tools to understand and study neuroplastic nervous system changes associated with rehabilitation. The center harnesses outstanding expertise in non-invasive NM, rehabilitation, operant conditioning of brain and spinal networks and animal models of NM4R. teams have formed a cohesive NM4R Community, returning to our center for multiple workshops and hands-on training experiential sessions, receiving follow-on consultations leading to pilot awards and extramural funding, and have publishing in peer-reviewed journals. The overarching goal over the new grant period is to impact multiple priorities of the NIH Research Plan for Rehabilitation (RPR) – most notably to translational science, pediatric rehabilitation and research design and methodology – by increasing rehabilitation research workforce access to NM4R approaches and supporting rigorous clinical research to translate them into effective, evidence-based rehabilitation interventions. Our Specific Aims are to: AIM 1. Increase the size and diversity of the rehabilitation research workforce with access to NM4R approaches; and AIM 2. Increase the impact of NM4R approaches. In the proposed renewal, our center will design yearly strategic activities to focus on impacting RPR priorities. Adjacent fields such as psychiatry are more advanced in applying NM tools in an emerging circuit-based medical model. NC NM4R will serve a vital purpose by infusing NM skills throughout the rehabilitation workforce and ensuring early exposure to the cutting edge of NM research for rehabilitation researchers in all domains.

总体而言——项目概要/摘要 康复至关重要需要与神经系统的相互作用。因此，神经调节（NM）是一种工具 能够通过一套共同原则来解决大量的情况和人群，这些原则是独一无二的 是新兴的基于神经回路的康复和医学方法的基础。我们的基本信念是 将 NM 应用于特定网络为推进和改进几乎所有领域提供了出色的前景 康复。尽管在过去五年中不断发展，NM 康复领域（NM4R – NM 和康复的结合）仍处于萌芽阶段，刚刚开始对临床实践产生影响 康复。国家神经调节康复中心 (NC NM4R) 的更新 南卡罗来纳医科大学 (MUSC) 在我们早期成功的基础上，推动了以下关键步骤： 开发下一代 NM4R 干预措施和使用这些工具所需的发现过程 了解和研究与康复相关的神经可塑性神经系统变化。中心 利用非侵入性 NM、康复、大脑和脊柱操作调节方面的杰出专业知识 NM4R 的网络和动物模型。团队已经形成了一个有凝聚力的 NM4R 社区，返回我们的中心 对于多个研讨会和实践培训体验课程，接受后续咨询，从而 试点奖项和校外资助，并在同行评审期刊上发表文章。总体目标结束 新的资助期将影响 NIH 康复研究计划 (RPR) 的多个优先事项——大多数 尤其是转化科学、儿科康复以及研究设计和方法——通过增加 康复研究人员可以使用 NM4R 方法并支持严格的临床研究 将它们转化为有效的、基于证据的康复干预措施。我们的具体目标是： AIM 1。 通过使用 NM4R 方法，增加康复研究队伍的规模和多样性； 目标 2. 提高 NM4R 方法的影响。在拟议的更新中，我们的中心将每年设计 战略活动重点关注影响 RPR 优先事项。精神病学等邻近领域更为先进 在新兴的基于电路的医学模型中应用 NM 工具。 NC NM4R 将通过注入 整个康复队伍的 NM 技能并确保尽早接触 NM 研究的前沿 适用于所有领域的康复研究人员。