National Center of Neuromodulation for Rehabilitation (NC NM4R)

总体-项目总结/摘要 康复至关重要的是需要与神经系统的相互作用。因此，神经调节（NM）是一种工具， 通过一套共同的原则， 是一种新兴的基于神经回路的康复和医学方法的基础。我们的基本信念是， 将网络管理应用于特定的网络，为推进和改善几乎所有领域的网络管理提供了出色的前景。 康复活动.虽然在过去五年中有所增长，但用于康复的NM领域（NM 4 R- NM和康复的组合）仍然是新生的，并且刚刚开始在临床上影响 康复活动.国家神经调节康复中心（NC NM 4 R）的更新 南卡罗来纳州医科大学（MUSC）建立在我们早期的成功，以促进在 开发下一代NM 4 R干预措施和使用这些工具所需的发现过程 了解和研究与康复相关的神经可塑性神经系统变化。中心 利用非侵入性NM，康复，大脑和脊柱操作性调节方面的杰出专业知识 网络和动物模型的NM 4 R。团队已经形成了一个有凝聚力的NM 4 R社区，回到我们的中心 参加多个研讨会和实践培训体验课程，接受后续咨询， 试点奖励和校外资助，并在同行评审的期刊上发表文章。总体目标是 新的拨款期将影响NIH康复研究计划（RPR）的多个优先事项， 特别是转化科学，儿科康复和研究设计和方法-通过增加 康复研究人员获得NM 4 R方法，并支持严格的临床研究， 将其转化为有效的循证康复干预措施。我们的具体目标是：目标1。 通过使用NM 4 R方法，增加康复研究人员的规模和多样性; 目标2增加NM 4 R方法的影响。在建议的更新中，我们中心将每年设计 战略活动的重点是影响RPR的优先事项。精神病学等邻近领域则更为先进 在新兴的基于电路的医疗模型中应用NM工具。NC NM 4 R将通过注入 NM技能在整个康复劳动力，并确保早期接触到NM研究的前沿 康复研究人员在所有领域。

OVERALL – PROJECT SUMMARY / ABSTRACT Rehabilitation crucially requires interaction with the nervous system. Thus, neuromodulation (NM) is a tool uniquely able to address a large number of conditions and populations through a set of common principles that underlie an emerging neural circuit-based approach to rehabilitation and medicine. Our foundational belief is that applying NM to specific networks offers outstanding promise for advancing and improving nearly all fields of rehabilitation. While having grown over the past five years, the field of NM for rehabilitation (NM4R – the combination of NM and rehabilitation) is still nascent and is just beginning to clinically impact the practice of rehabilitation. The renewal of the National Center of Neuromodulation for Rehabilitation (NC NM4R) at the Medical University of South Carolina (MUSC) builds upon our early successes to facilitate the key steps in the discovery process that are required to develop the next generation of NM4R interventions and to use these tools to understand and study neuroplastic nervous system changes associated with rehabilitation. The center harnesses outstanding expertise in non-invasive NM, rehabilitation, operant conditioning of brain and spinal networks and animal models of NM4R. teams have formed a cohesive NM4R Community, returning to our center for multiple workshops and hands-on training experiential sessions, receiving follow-on consultations leading to pilot awards and extramural funding, and have publishing in peer-reviewed journals. The overarching goal over the new grant period is to impact multiple priorities of the NIH Research Plan for Rehabilitation (RPR) – most notably to translational science, pediatric rehabilitation and research design and methodology – by increasing rehabilitation research workforce access to NM4R approaches and supporting rigorous clinical research to translate them into effective, evidence-based rehabilitation interventions. Our Specific Aims are to: AIM 1. Increase the size and diversity of the rehabilitation research workforce with access to NM4R approaches; and AIM 2. Increase the impact of NM4R approaches. In the proposed renewal, our center will design yearly strategic activities to focus on impacting RPR priorities. Adjacent fields such as psychiatry are more advanced in applying NM tools in an emerging circuit-based medical model. NC NM4R will serve a vital purpose by infusing NM skills throughout the rehabilitation workforce and ensuring early exposure to the cutting edge of NM research for rehabilitation researchers in all domains.