National Center of Neuromodulation for Rehabilitation (NC NM4R)

总体--项目摘要/摘要 康复至关重要的是需要与神经系统相互作用。因此，神经调节(NM)是一种工具 独一无二地能够通过一套共同的原则来解决大量的条件和人口问题 这是一种新兴的基于神经回路的康复和医学方法。我们的基本信念是 将NM应用于特定网络为推进和改进几乎所有领域提供了突出的前景 康复。虽然在过去五年中有所增长，但NM康复领域(NM4R-The NM和康复的结合)仍处于萌芽状态，并刚刚开始影响临床实践 康复。国家神经调节康复中心(NC NM4R)在北京举行的更新 南卡罗来纳医科大学(MUSC)在我们早期成功的基础上，促进了 开发下一代NM4R干预措施和使用这些工具所需的发现过程 了解和研究与康复相关的神经再生神经系统变化。中心 利用在非侵入性NM、康复、脑和脊柱的可操作性调节方面的杰出专业知识 NM4R的网络和动物模型。团队组成了一个有凝聚力的NM4R社区，回到了我们的中心 对于多个研讨会和实践培训体验会议，接受后续咨询导致 试点奖项和校外资助，并在同行评议的期刊上发表文章。首要目标是 新的赠款期限将影响NIH康复研究计划(RPR)的多个优先事项-MOST 尤其是转化科学、儿科康复和研究设计和方法--通过增加 康复研究人员获得NM4R方法并支持严格的临床研究 将其转化为有效的、循证的康复干预措施。我们的具体目标是：目标1。 通过使用NM4R方法，增加康复研究人员的规模和多样性； 和目标2.增加NM4R方法的影响。在拟议的更新中，我们中心将每年设计一次 开展战略活动，侧重于影响区域政策审查的优先事项。邻近的领域，如精神病学，更先进 在新兴的基于电路的医疗模式中应用NM工具。NC NM4R将通过注入 在康复劳动力中掌握NM技能，并确保及早接触NM研究的前沿 面向各个领域的康复研究人员。

OVERALL – PROJECT SUMMARY / ABSTRACT Rehabilitation crucially requires interaction with the nervous system. Thus, neuromodulation (NM) is a tool uniquely able to address a large number of conditions and populations through a set of common principles that underlie an emerging neural circuit-based approach to rehabilitation and medicine. Our foundational belief is that applying NM to specific networks offers outstanding promise for advancing and improving nearly all fields of rehabilitation. While having grown over the past five years, the field of NM for rehabilitation (NM4R – the combination of NM and rehabilitation) is still nascent and is just beginning to clinically impact the practice of rehabilitation. The renewal of the National Center of Neuromodulation for Rehabilitation (NC NM4R) at the Medical University of South Carolina (MUSC) builds upon our early successes to facilitate the key steps in the discovery process that are required to develop the next generation of NM4R interventions and to use these tools to understand and study neuroplastic nervous system changes associated with rehabilitation. The center harnesses outstanding expertise in non-invasive NM, rehabilitation, operant conditioning of brain and spinal networks and animal models of NM4R. teams have formed a cohesive NM4R Community, returning to our center for multiple workshops and hands-on training experiential sessions, receiving follow-on consultations leading to pilot awards and extramural funding, and have publishing in peer-reviewed journals. The overarching goal over the new grant period is to impact multiple priorities of the NIH Research Plan for Rehabilitation (RPR) – most notably to translational science, pediatric rehabilitation and research design and methodology – by increasing rehabilitation research workforce access to NM4R approaches and supporting rigorous clinical research to translate them into effective, evidence-based rehabilitation interventions. Our Specific Aims are to: AIM 1. Increase the size and diversity of the rehabilitation research workforce with access to NM4R approaches; and AIM 2. Increase the impact of NM4R approaches. In the proposed renewal, our center will design yearly strategic activities to focus on impacting RPR priorities. Adjacent fields such as psychiatry are more advanced in applying NM tools in an emerging circuit-based medical model. NC NM4R will serve a vital purpose by infusing NM skills throughout the rehabilitation workforce and ensuring early exposure to the cutting edge of NM research for rehabilitation researchers in all domains.