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中文摘要
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描述(由申请人提供):纽约大学医学中心是纽约市在医疗保健、生物医学研究、教育和公共服务方面领先的卓越中心。飓风桑迪对纽兰大学的研究基础设施造成了灾难性的破坏。结果,两个动物设施,Smilow地窖动物饲养场和MSB动物饲养场无法用于研究。这项建议的目的是恢复啮齿动物屏障和非屏障住房。此外,在飓风发生时,由美国国立卫生研究院(NIH)资助的G20翻新赠款(RR-030901)正在MSB动物园内进行。由于MSB不再用于研究,本提案的目标也寻求恢复G20的目标之一。拟议的建设将在纽伦大学主校区的NSB进行。这项研究基础设施的更换将能够支持研究人员,目前每年总共有81,116,830美元的活跃研究经费和116,218,917美元的未决研究经费。这项提案中包括的恢复将影响纽拉大学动物研究的能力和质量,这是保留现有研究人员所必需的,并使纽拉大学几乎所有基础科学系都能额外招聘教师。
英文摘要
DESCRIPTION (provided by applicant): NYULMC is a leading center of excellence in health care, biomedical research, education, and public service in New York City. Hurricane Sandy resulted in catastrophic damage to NYULMC research infrastructure. As a result, two animal facilities, the Smilow cellar vivarium and the MSB vivarium were rendered unusable for research. The Aims of this proposal are to restore rodent barrier and non-barrier housing. In addition, at the time of the hurricane, a National Institute of health (NIH)-funded G20 renovation grant (RR-030901) was underway in the MSB vivarium. As MSB is no longer usable for research, the Aims of this proposal seek to recover one of the G20 Aims as well. The proposed construction will take place above grade at the NSB on the NYULMC main campus. This replacement of research infrastructure will be able to support investigators with a current annual total of $81,116,830 in active and $116,218,917 in pending research grants. The restoration included in this proposal will impact the capacity and quality of animal research at NYULMC necessary to retain existing investigators and enable additional recruitment of faculty in almost all of the basic science departments at NYULMC.
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A novel monobody-drug conjugate to treat mutant KRas pancreatic cancer.
  • 批准号:
    10666997
  • 项目类别:
  • 资助金额:
    $21.0万
  • 财政年份:
    2022
  • 负责人:
    DAFNA BAR-SAGI
  • 依托单位:
A novel monobody-drug conjugate to treat mutant KRas pancreatic cancer.
  • 批准号:
    10323748
  • 项目类别:
  • 资助金额:
    $39.87万
  • 财政年份:
    2021
  • 负责人:
    DAFNA BAR-SAGI
  • 依托单位:
A novel monobody-drug conjugate to treat mutant Ras multiple myeloma
  • 批准号:
    10080987
  • 项目类别:
  • 资助金额:
    $39.99万
  • 财政年份:
    2020
  • 负责人:
    DAFNA BAR-SAGI
  • 依托单位:
Dectin-1 signaling drives pancreatic oncogenesis by inducing macrophage-mediated adaptive immune suppression
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