Legacy continuation of the KU CMLD Mission

KU CMLD 使命的延续

• 批准号: 8753214
• 负责人: THOMAS EDWARD PRISINZANO
• 金额: $ 54.06万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8753214
• 关键词: Acute; Address; Award; Back; Biological; Biological Assay; Biology; Biomedical Research; Charge; Chemicals; Client; Clinical Trials; Collection; Communities; Development; Elements; Ensure; Evaluation; Funding; Funding Mechanisms; Funding Opportunities; Future; Goals; Kansas; Libraries; Library Collection Development; Liquid Chromatography; Maintenance; Methodology; Methods; Metric; Mission; Modeling; Molecular Bank; NIH Program Announcements; National Institute of General Medical Sciences; Pharmaceutical Chemistry; Powder dose form; Preparation; Process; Public Sector; Publications; Publishing; Quality Control; Recovery; Research; Research Personnel; Research Project Grants; Resources; Sampling; Scientist; Staging; Structure; Testing; United States National Institutes of Health; Universities; Validation; analog; base; cost; drug discovery; high throughput screening; interest; member; milligram; novel; operation; outreach; programs; public health relevance; repository; screening; small molecule; small molecule libraries

DESCRIPTION (provided by applicant): To provide academic researchers with high-quality compound collections for biological screening, the National Institute of General Medical Sciences established the Chemical Methodologies and Library Development (CMLD) Network and charged it with developing new ways of creating libraries and providing them to the SMR. The CMLD network was maintained under a R41 funding mechanism and has been discontinued, making it eligible for consideration as a legacy resource under the present program announcement. As part of the CMLD network, the University of Kansas CMLD center was responsible for developing numerous chemical methods and for providing >7000 compounds to the SMR. Most excitingly, numerous KU CMLD center compounds have been identified as hits in diverse screens, with a few progressing to full-blown development efforts currently underway. The NIH plans to maintain the SMR for the foreseeable future, with new screens being enabled by currently active, project-specific R01 awards (PAR-12-058), meaning that new hits will continue to be identified. However, the ability of researchers to have continued access to non-commercial compounds, which constitute a valuable and unique asset of the repository, is threatened by diminishing supplies of these compounds, many of which have been depleted. This threat is particularly acute with respect to pure samples (generally powders) that are essential for validation efforts following the initial screen. We propose to address these concerns through the present program. Our near-term goal is to supply scientists who have uncovered screening hits in the SMR with structurally validated quantitatively quality-controlled samples of the hit of interest as well as chemically similar analogs for validation efforts. This wll require a sustained effort in scientific outreach to maximize the potential client base for these activities as well as technical maintenance of our synthetic and compound purification/management capabilities Our long-term goal is to transform our library synthesis and hit validation activities into a sustainable effort that will eventually be supported by cost recovry from project-specific research grants and charge-backs to clients.

描述（由申请人提供）：为了给学术研究人员提供高质量的化合物集合用于生物筛选，美国国家普通医学科学研究所建立了化学方法和文库开发网络，并负责开发创建文库的新方法并将其提供给SMR。CMLD网络是在R41资助机制下维持的，并且已经停止，使其有资格作为当前项目公告下的遗留资源进行考虑。作为CMLD网络的一部分，堪萨斯大学CMLD中心负责开发多种化学方法，并向SMR提供了17000种化合物。最令人兴奋的是，许多KU CMLD中心化合物已经在不同的筛选中被确定为热门药物，其中一些正在进行全面的开发工作。NIH计划在可预见的未来维持SMR，新的筛选将由当前活跃的、特定项目的R01奖励（PAR-12-058）启用，这意味着新的热门将继续被确定。然而，研究人员的能力一直在继续