Chemical Biology of Infectious Disease

 描述(申请人提供)：传染病新疗法的开发是生物医学科学的一个重大挑战，因为对现有疗法具有抗药性的生物体不断扩大，曾经被认为已被征服的传染病病原体重新出现，以及缺乏有效治疗的传染病的传播。本提案旨在建立一个生物医学研究卓越中心，以传染病化学生物学为多学科主题。化学生物学需要发现能够调节与感染过程相关的途径的化学实体，并可能导致确定新的化学干预目标。拟建的中心将 加强基础设施，使堪萨斯州的科学家和生物医学研究成为可能，并由经验丰富的研究人员和科学管理人员、大学杰出教授杰弗里·奥贝领导。它将解决以下具体目标：(1)提供一个世界级的环境，适当地管理和配备人员，使研究人员能够获得与传染病化学生物学有关的关键技术。(2)支持和使初级教员通过积极的指导、获得适当的资源和资助有价值的计划来建立成功的研究计划。(3)通过招聘优秀的初级教员、建立系列研讨会和其他丰富科学知识的机会，并向所有感兴趣的研究人员提供核心设施，加强整个区域科学界的传染病研究。

 DESCRIPTION (provided by applicant): The development of new treatments of infectious disease is a preeminent challenge of biomedical science due to the continued expansion of organisms resistant to existing therapies, the reemergence of infectious agents once thought vanquished, and the spread of infectious diseases lacking effective treatments. The present proposal seeks to establish a Center for Biomedical Research Excellence with a multidisciplinary theme of Chemical Biology of Infectious Disease. Chemical biology entails the discovery of chemical entities able to modulate pathways related to infectious processes and can lead to the identification of novel targets for chemical intervention. The proposed Center will strengthen infrastructure and enable scientists and biomedical research in the State of Kansas and be led by University Distinguished Professor Jeffrey Aube, an experienced researcher and scientific administrator. It will address the following specific aims: (1) Provide a world-class environment, appropriately administered and staffed, to provide researchers access to key techniques relevant to the chemical biology of infectious disease. (2) Support and enable junior faculty to build successful research programs through active mentorship, access to appropriate resources, and funding of meritorious programs. (3) Enhance infectious disease research throughout the regional scientific community by the recruitment of outstanding junior faculty, establishment of seminar series and other opportunities for scientific enrichment, and by providing core facility access to all interested researchers.