Chemical Biology of Infectious Disease

 描述（由申请人提供）：由于对现有疗法具有抗性的生物体的持续扩张、曾经被认为已被征服的传染性病原体的重新出现以及缺乏有效治疗的传染性疾病的传播，开发传染性疾病的新治疗方法是生物医学科学的一项突出挑战。本提案旨在建立一个生物医学研究卓越中心，以传染病的化学生物学为多学科主题。化学生物学需要发现能够调节与感染过程相关的途径的化学实体，并可能导致识别化学干预的新靶点。拟建中心将 加强基础设施，使堪萨斯州的科学家和生物医学研究，并由大学杰出教授杰弗里奥布，经验丰富的研究人员和科学管理人员领导。它将实现以下具体目标：（1）提供一个世界一流的环境，适当管理和配备人员，为研究人员提供与传染病化学生物学相关的关键技术。(2)支持和使初级教师通过积极的导师，获得适当的资源，并有价值的计划的资金建立成功的研究计划。(3)通过招募优秀的初级教师，建立系列研讨会和其他科学丰富的机会，并通过向所有感兴趣的研究人员提供核心设施，加强整个区域科学界的传染病研究。

 DESCRIPTION (provided by applicant): The development of new treatments of infectious disease is a preeminent challenge of biomedical science due to the continued expansion of organisms resistant to existing therapies, the reemergence of infectious agents once thought vanquished, and the spread of infectious diseases lacking effective treatments. The present proposal seeks to establish a Center for Biomedical Research Excellence with a multidisciplinary theme of Chemical Biology of Infectious Disease. Chemical biology entails the discovery of chemical entities able to modulate pathways related to infectious processes and can lead to the identification of novel targets for chemical intervention. The proposed Center will strengthen infrastructure and enable scientists and biomedical research in the State of Kansas and be led by University Distinguished Professor Jeffrey Aube, an experienced researcher and scientific administrator. It will address the following specific aims: (1) Provide a world-class environment, appropriately administered and staffed, to provide researchers access to key techniques relevant to the chemical biology of infectious disease. (2) Support and enable junior faculty to build successful research programs through active mentorship, access to appropriate resources, and funding of meritorious programs. (3) Enhance infectious disease research throughout the regional scientific community by the recruitment of outstanding junior faculty, establishment of seminar series and other opportunities for scientific enrichment, and by providing core facility access to all interested researchers.