Alteration and Renovation

改建和翻新

• 批准号: 8812380
• 负责人: THOMAS EDWARD PRISINZANO
• 金额: $ 9.28万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8812380
• 关键词: Biological; Biological Assay; Biology; Chemicals; Communicable Diseases; Containment; Equipment; Funding; Housing; Infectious Agent; Kansas; Laboratories; Location; Research; Screening procedure; Time; Universities; Validation; assay development; hazard; high throughput screening; screening; small molecule libraries; square foot; structural biology

Project Summary Effective and efficient high-throughput screening (HTS) of large chemical libraries requires many carefully coordinated efforts that span target selection through assay validation and into automated large-scale screening. Additionally, assay development and performing high-throughput screening for infectious disease targets can often require special consideration and conditions due to biological hazard and containment issues. To provide for these special considerations and minimize the impact of infectious agents on the general activities of the HTS facility and associated equipment, we propose to renovate space adjacent to the high- throughput screening facility such that it is suitable for performing infectious disease assay development and limited chemical screening associated with Core B. The proposed renovations would provide 211 sq ft of laboratory space dedicated for infectious disease assay development and many high-throughput screening procedures. The proposed laboratory would be suitably equipped through direct contributions from the University of Kansas. Timing for renovations to be completed are estimated to be within six months after receipt of funds.

项目摘要 有效和高效的大规模化学文库的高通量筛选（HTS）需要许多仔细的 协调努力，涵盖目标选择、分析验证和自动化大规模 筛选此外，检测方法的开发和对传染病进行高通量筛查 由于生物危害和密封问题，目标往往需要特殊考虑和特殊条件。 提供这些特别考虑因素，并尽量减少传染性病原体对一般 活动的HTS设施和相关设备，我们建议翻新空间毗邻的高， 通量筛选设施，使得其适合于进行传染病测定开发， 与核心B相关的有限化学筛选。拟议的翻修将提供211平方英尺的 专门用于传染病检测开发和许多高通量筛选的实验室空间 程序.拟议实验室的设备将由 堪萨斯大学。预计翻修工程将在2010年12月31日之后的六个月内完成。 收到资金。