Chemical Biology of Infectious Disease

传染病化学生物学

基本信息

批准号：
9274106
负责人：
THOMAS EDWARD PRISINZANO
金额：
$ 226.53万
依托单位：
UNIVERSITY OF KANSAS LAWRENCE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-15 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9274106
关键词：
Address Administrator Animals Area Biological Biological Models Biological Sciences Biology Biomedical Research Centers of Research Excellence Chemicals Chemotherapy-Oncologic Procedure Communicable Diseases Communities Core Facility Development Environment Facility Accesses Faculty Funding Future Human Infectious Agent Infectious Diseases Research Institution Intervention Kansas Lead Mentors Mentorship Microbiology Modernization Molecular Organism Pathogenesis Pathway interactions Peer Review Pharmaceutical Chemistry Pharmacologic Substance Pharmacology Principal Investigator Process Proteomics Public Health Recruitment Activity Research Research Infrastructure Research Personnel Resistance Resources Science Scientist Series Techniques United States National Institutes of Health Universities Validation Virulence Factors Work antimicrobial distinguished professor drug discovery effective therapy experience high throughput screening infectious disease treatment interest microbial microbiota mid-career faculty multidisciplinary novel pathogen professor programs public health relevance tool

项目摘要

DESCRIPTION (provided by applicant): The development of new treatments of infectious disease is a preeminent challenge of biomedical science due to the continued expansion of organisms resistant to existing therapies, the reemergence of infectious agents once thought vanquished, and the spread of infectious diseases lacking effective treatments. The present proposal seeks to establish a Center for Biomedical Research Excellence with a multidisciplinary theme of Chemical Biology of Infectious Disease. Chemical biology entails the discovery of chemical entities able to modulate pathways related to infectious processes and can lead to the identification of novel targets for chemical intervention. The proposed Center will strengthen infrastructure and enable scientists and biomedical research in the State of Kansas and be led by University Distinguished Professor Jeffrey Aube, an experienced researcher and scientific administrator. It will address the following specific aims: (1) Provide a world-class environment, appropriately administered and staffed, to provide researchers access to key techniques relevant to the chemical biology of infectious disease. (2) Support and enable junior faculty to build successful research programs through active mentorship, access to appropriate resources, and funding of meritorious programs. (3) Enhance infectious disease research throughout the regional scientific community by the recruitment of outstanding junior faculty, establishment of seminar series and other opportunities for scientific enrichment, and by providing core facility access to all interested researchers.

描述（由适用提供）：由于有生物体对现有疗法具有抗药性，感染力的再生能力曾经被认为消失的疾病的再出现，传染病科学的新疗法的发展是生物医学科学的巨大挑战。本提案旨在建立一个卓越生物医学研究中心，具有传染病化学生物学的多学科主题。化学生物学吸引了发现能够调节与传染过程相关的途径的化学实体的发现，并可能导致确定化学干预的新靶标。拟议的中心将加强堪萨斯州的基础设施并使科学家和生物医学研究，并由大学杰出教授杰弗里·安（Jeffrey Abe）领导，他是经验丰富的研究员和科学管理员。它将解决以下具体目标：（1）提供适当管理和人员配备的世界一流环境，以使研究人员获得与传染病化学生物学相关的关键技术。（2）支持并使初级教师能够在积极的心态，获得适当的资源以及对优异计划的资金资金中建立成功的研究计划。（3）通过招募杰出的初级教师，开创性系列和其他科学酶的机会，并通过向所有感兴趣的研究人员提供核心设施，从而增强了整个区域科学界的传染病研究。