Hedgehog signaling and signal transduction

Hedgehog信号传导和信号转导

• 批准号: 8632014
• 负责人: THOMAS B. KORNBERG
• 金额: $ 29.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-15 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8632014
• 关键词: Address; Alleles; Animals; Area; Behavior; Biology; Brain; Breast; C-terminal; Caliber; Cancer cell line; Cells; Cholesterol; Clinical Trials; Colon; Data; Development; Disease; Drug or chemical Tissue Distribution; Erinaceidae; Genetic; Hematologic Neoplasms; Homeostasis; Image; Invertebrates; Learning; Length; Life; Location; Lung; Malignant Neoplasms; Malignant neoplasm of pancreas; Measures; Methods; Monitor; Movement; Organ; Output; Palmitates; Pathway interactions; Physiological; Play; Process; Production; Prostate; Proteins; Publishing; RNA Interference; Reagent; Regimen; Regulation; Resistance; Resolution; Role; Signal Transduction; Skin Cancer; Staging; System; Therapeutic; Time; Tissues; Transgenes; Vertebrates; Work; body system; cancer therapy; chemotherapy; fly; hedgehog signal transduction; human SMO protein; improved; mutant; pancreatic cancer cells; public health relevance; response; smoothened signaling pathway; stem cell niche; tissue fixing; tool; transcription factor

Project Summary/Abstract Hedgehog signaling has been implicated in many cancers and has been shown to be a useful target for anti-cancer therapy. Previous work, including key contributions from my lab, have established that the Hedgehog protein is one of the major regulators of animal development, playing key roles in most tissues and organs in both invertebrates and vertebrates. Using newly developed reagents and methods that open new ways to study Hh signaling, the work proposed in this application will identify and characterize the processes that Hh-producing cells use to prepare and deliver Hh protein, the processes that Hh-receiving cells use to prepare for and handle its arrival, and the processes that regulate the form and activity of Ci, the transcription factor that is responsible for Hh pathway output. These issues are critical to understanding how new and better therapeutic regimens controlling Hh activity can be developed.

项目总结/摘要 Hedgehog信号传导与许多癌症有关，并且已被证明是治疗癌症的有用靶标。 抗癌治疗以前的工作，包括我的实验室的主要贡献，已经确定， Hedgehog蛋白是动物生长发育的主要调节因子之一，在许多组织中起着关键作用 以及脊椎动物和无脊椎动物的器官。使用新开发的试剂和方法， 研究Hh信号的新方法，本申请中提出的工作将识别和表征 产生Hh的细胞用于制备和递送Hh蛋白的过程， 细胞用来准备和处理它的到来，以及调节Ci的形式和活性的过程， 负责Hh途径输出的转录因子。这些问题对于理解 如何开发新的和更好的控制Hh活性的治疗方案。