Gene regulation and function in early embryos

描述（由申请人提供）：细胞周期进展、细胞迁移和基因表达发生在错误的时间或地点，或调节不准确，可能导致 发育异常，并可能导致疾病状态。有许多系统可以研究，以提高我们对细胞周期，细胞运动和基因表达的理解。具有几个独特优势的是早期的果蝇胚胎，当核循环在受精后的前两个小时内产生大约4000个核时。这些早期周期提供了为数不多的易于处理的系统之一，既具有高度一致性，又具有缩短且明显简化的细胞周期。这个提议描述了对这些核分裂的研究;作为提议的实验基础的发现已经表明，我们对这个早期的、关键的发展阶段的理解必须彻底改变。

DESCRIPTION (provided by applicant): Cell cycle progression, cell migrations and gene expression that occur at the wrong time or place, or that are inaccurately regulated, can result in abnormal development and can lead to disease states. There are many systems that can be studied to improve our understanding of the cell cycle, cell movements and gene expression. One that has several unique advantages is the early Drosophila embryo when nuclear cycles produce approximately four thousand nuclei within the first two hours after fertilization. These early cycles offer one of the few tractable systems with both high uniformity and an abbreviated and apparently simplified cell cycle. This proposal describes an investigation of these nuclear divisions; findings that are the basis for the proposed experiments already reveal that our understanding of this early, critical stage of development must change radically.