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MOLECULAR AND CELLULAR BIOCHEMISTRY CORE

分子和细胞生物化学核心

基本信息

批准号：
8578084
负责人：
DAVID E. COHEN
金额：
$ 21.14万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8578084
关键词：
Affinity Area Bacteria Basic Science Bile fluid Biliary Biochemical Biochemistry Biological Assay Biological Models Biology Biophysics Body Fluids Boston Cell Culture Techniques Cell physiology Cells Cellular biology Cloning Consultations Detection Development Digestion Digestive System Disorders Ensure Epithelial Epithelial Cells Equipment Equus caballus Exclusion Fluorescence Fostering Fractionation Gastrointestinal tract structure Genotype High Pressure Liquid Chromatography Hospitals Host Defense Hypersensitivity Insecta Institution Interdisciplinary Study Intestinal Content Intestines Isoelectric Focusing Laboratories Lipid Biochemistry Lipids Lipoproteins Liquid Chromatography Liver Mass Spectrum Analysis Medical Messenger RNA Methods Mission Molecular Molecular Analysis Mucosal Immunity Mus Neoplasms Nucleic Acids Organelles Pancreas Pediatric Hospitals Peptides Plasma Post-Translational Protein Processing Preparation Procedures Productivity Protein Analysis Protein Biochemistry Proteins Proteomics Protocols documentation Reader Reagent Recombinant Proteins Recruitment Activity Research Research Personnel Resources Sampling Satellite Hospitals Scientist Services Solutions Specialist Specimen Spectrometry, Mass, Electrospray Ionization System Techniques Technology Thin Layer Chromatography Time Tissues Training Translational Research Update Western Blotting Woman Work absorption base cost effective design detector expression vector fast protein liquid chromatography gastrointestinal improved in vivo instrument instrumentation luminescence mass spectrometer medical schools meetings member operation programs protein complex protein expression protein purification research and development small molecule theories tissue/cell preparation vector

项目摘要

Introduction to Center and Core Missions The Harvard Digestive Disease Center is focused on the cell biology and function of epithelial cells of the alimentary tract, liver, and pancreas; and how epithelial biology manifests itself in mucosal immunity and allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract. The Center aims to facilitate multidisciplinary research in this field by providing technical resources. Core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in the Longwood Medical Area. We also aim to recruit new and established investigators into the fields of gastrointestinal biology. Our overarching mission is to foster better basic and translational science in fields related to digestive diseases by: "connecting people, 'creating opportunity, and 'extending resources. Shared intellectual and scientific resources to enhance this effort and the productivity of our research base are provided by four service Cores and an Administrative Core (see Figure 1-CoreD). Each Core provides the following general resources to the HDDC: ¿ Core Services ¿ Materials and Reagents ¿ Instrumentation and Equipment -Expertise, Protocols, and Training ¿ Core-development research Core D provided HDDC members with needed work-horse technologies in protein and lipid biochemistry and a full array of advanced services in Proteomics.

中心和核心任务介绍哈佛消化疾病中心专注于消化道、肝脏和胰腺上皮细胞的细胞生物学和功能;以及上皮生物学如何在粘膜免疫和过敏、先天宿主防御、消化和吸收、胃肠道肿瘤的发展以及胃肠道的许多其他功能中表现出来。该中心旨在通过提供技术资源促进该领域的多学科研究。核心服务，科学专业知识，以及一个重要的交汇点，以促进哈佛附属医院，哈佛医学院和朗伍德医学区相邻研究机构的独立研究者之间的密切科学和知识关系。我们还旨在招募新的和建立的研究人员进入胃肠道生物学领域。我们的首要使命是通过“连接人”、"创造机会“和”扩展资源“，在消化系统疾病相关领域促进更好的基础和转化科学。共享的智力和科学资源，以加强这一努力和我们的研究基地的生产力是由四个服务核心和行政核心（见图1-核心D）。每个核心向HDDC提供以下一般资源：核心服务、材料和试剂核心开发研究核心D为HDDC成员提供了蛋白质和脂质生物化学方面所需的主力技术以及蛋白质组学方面的全套先进服务。