Molecular Immunopathology Core

分子免疫病理学核心

• 批准号: 8751067
• 负责人: Kevin R. Macaluso
• 金额: $ 15.43万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-02 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8751067
• 关键词: Address; Advertising; Animal Model; Animals; Antibody Formation; Appointment; Arthropod Vectors; Arthropods; Bioinformatics; Biological Assay; Biopsy; Cells; Centers of Research Excellence; Certification; Collaborations; Communicable Diseases; Confocal Microscopy; Core Facility; Development; Diagnosis; Disease; Ensure; Equipment; Faculty; Fees; Fiber; Flow Cytometry; Funding; Future; Goals; Grant; Human Resources; Ice; Image; Immune; Immunohistochemistry; Immunology; Immunophenotyping; In Vitro; Income; Individual; Infection; Infectious Diseases Research; Institution; Joints; Label; Laboratories; Laboratory Animal Medicine; Lasers; Lead; Leadership; Location; Louisiana; Methodology; Microscope; Microscopy; Molecular; Molecular Biology; Nature; Optics; Participant; Pathologist; Pathology; Phase; Postdoctoral Fellow; Primates; Process; Proteins; Protocols documentation; Reagent; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Rodent; Role; Sampling; Scanning Transmission Electron Microscopy Procedures; Schedule; Scientist; Services; Specialized Center; Students; Technology; Testing; Tissue Sample; Tissues; Training; United States National Institutes of Health; Veterinary Pathology; Videoconferences; Videoconferencing; Viral; Virus; Work; base; cell type; cost; data exchange; experience; graduate student; immunopathology; instrument; interest; investigator training; member; new technology; nonhuman primate; novel; pathogen; pathogenic bacteria; theories; web site

During the previous two Phases ofthe COBRE "Center for Experimental Infectious Disease Research (CEIDR)", the CEIDR Molecular Immunopathology Core (MIPC) leveraged support of multiple Core Facilities and Equipment at both LSU and Tulane National Primate Research Center (TNPRC) to support NIH-funded infectious disease research. The original MIPC remains intact except that two specialized functions dealing with molecular biology, NGS and bioinformatics are now covered by the Genelab while protein and antibody production and protein characterization is covered by the PCL. MIPC now leverages and coordinates Core activities in flow cytometry, pathology and microscopy at both ISU-SVM and TNPRC. All three activities constitute established Core laboratories operating as a consortium of cost centers at both ISU-SVM and TNPRC. MIPC Units are highly likely to be sustained in the future, since currently, ISU-SVM provides up to 80% ofall personnel costs, while TNPC facilities are supported by the Primate Center NIH base grant and a robust fee-for-sen/ice income. LSU facilities focus primarily on rodents and arthropod vectors, while TNPRC facilities almost exclusively focus on non-human primate (NHP) research support. Thus, it is projected that COBRE phase 111 funding for these facilities will be easily replaced by fee-for-sen/ice income, ensuring a self-sustaining future for MIPC facilities. It is envisioned that increasing collaboration among LSU and TNPRC scientists, as evidenced by the presence of three collaborative projects between LSU-SVM and TNPRC scientists and a jointly hired faculty member (recruitment in process), will lead to enhancement of know-how and support functions for all MIPC facilities. Certain functions ofthe MIPC are unique to either location. The MIPC aims to 1) Provide access to specialized equipment and molecular immunopathological and microscopy expertise to CEIDR researchers. 2) Train investigators and their staff in the theory and use of technologies available in MIPC. 3) Promote the development and use of new technologies and assays that can be used to characterize pathogen-host interactions in vitro and in experimental animal infections (small animals and NHP).

在COBRE“实验传染病研究中心”的前两个阶段 (CEIDR)”，CEIDR 分子免疫病理学核心 (MIPC) 利用多个核心的支持 路易斯安那州立大学和杜兰国家灵长类研究中心 (TNPRC) 的设施和设备支持 NIH 资助的传染病研究。原来的 MIPC 保持完整，除了两个专门的 Genelab 现在涵盖了涉及分子生物学、NGS 和生物信息学的功能，同时 PCL 涵盖蛋白质和抗体生产以及蛋白质表征。 MIPC 现在利用 并协调 ISU-SVM 和 TNPRC 流式细胞术、病理学和显微镜学方面的核心活动。 所有三项活动均构成已建立的核心实验室，作为成本中心联盟在 ISU-SVM 和 TNPRC。 MIPC 装置在未来极有可能得到维持，因为目前，ISU-SVM 提供高达 80% 的人员成本，而 TNPC 设施由 NIH 灵长类动物中心提供支持 基本补助金和丰厚的 sen/ice 费用收入。路易斯安那州立大学设施主要关注啮齿动物和节肢动物 载体，而 TNPRC 设施几乎完全专注于非人类灵长类动物 (NHP) 研究支持。 因此，预计 COBRE 第 111 阶段对这些设施的资助将很容易被 收费/冰收入，确保 MIPC 设施的自给自足的未来。预计将增加 路易斯安那州立大学和 TNPRC 科学家之间的合作，三个合作伙伴的存在就证明了这一点 LSU-SVM 和 TNPRC 科学家以及联合聘用的教员之间的项目（在 过程），将增强所有 MIPC 设施的专业知识和支持功能。肯定 MIPC 的功能对于任一地点来说都是独特的。 MIPC 的目标是 1) 提供专业的服务 向 CEIDR 研究人员提供设备和分子免疫病理学和显微镜专业知识。 2) 火车 研究人员及其工作人员了解 MIPC 中可用技术的理论和使用。 3) 推广 开发和使用可用于表征病原体宿主的新技术和检测方法 体外和实验动物感染（小动物和 NHP）中的相互作用。