Molecular Immunopathology Core

分子免疫病理学核心

• 批准号: 8751067
• 负责人: Kevin R. Macaluso
• 金额: $ 15.43万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-02 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8751067
• 关键词: Address; Advertising; Animal Model; Animals; Antibody Formation; Appointment; Arthropod Vectors; Arthropods; Bioinformatics; Biological Assay; Biopsy; Cells; Centers of Research Excellence; Certification; Collaborations; Communicable Diseases; Confocal Microscopy; Core Facility; Development; Diagnosis; Disease; Ensure; Equipment; Faculty; Fees; Fiber; Flow Cytometry; Funding; Future; Goals; Grant; Human Resources; Ice; Image; Immune; Immunohistochemistry; Immunology; Immunophenotyping; In Vitro; Income; Individual; Infection; Infectious Diseases Research; Institution; Joints; Label; Laboratories; Laboratory Animal Medicine; Lasers; Lead; Leadership; Location; Louisiana; Methodology; Microscope; Microscopy; Molecular; Molecular Biology; Nature; Optics; Participant; Pathologist; Pathology; Phase; Postdoctoral Fellow; Primates; Process; Proteins; Protocols documentation; Reagent; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Rodent; Role; Sampling; Scanning Transmission Electron Microscopy Procedures; Schedule; Scientist; Services; Specialized Center; Students; Technology; Testing; Tissue Sample; Tissues; Training; United States National Institutes of Health; Veterinary Pathology; Videoconferences; Videoconferencing; Viral; Virus; Work; base; cell type; cost; data exchange; experience; graduate student; immunopathology; instrument; interest; investigator training; member; new technology; nonhuman primate; novel; pathogen; pathogenic bacteria; theories; web site

During the previous two Phases ofthe COBRE "Center for Experimental Infectious Disease Research (CEIDR)", the CEIDR Molecular Immunopathology Core (MIPC) leveraged support of multiple Core Facilities and Equipment at both LSU and Tulane National Primate Research Center (TNPRC) to support NIH-funded infectious disease research. The original MIPC remains intact except that two specialized functions dealing with molecular biology, NGS and bioinformatics are now covered by the Genelab while protein and antibody production and protein characterization is covered by the PCL. MIPC now leverages and coordinates Core activities in flow cytometry, pathology and microscopy at both ISU-SVM and TNPRC. All three activities constitute established Core laboratories operating as a consortium of cost centers at both ISU-SVM and TNPRC. MIPC Units are highly likely to be sustained in the future, since currently, ISU-SVM provides up to 80% ofall personnel costs, while TNPC facilities are supported by the Primate Center NIH base grant and a robust fee-for-sen/ice income. LSU facilities focus primarily on rodents and arthropod vectors, while TNPRC facilities almost exclusively focus on non-human primate (NHP) research support. Thus, it is projected that COBRE phase 111 funding for these facilities will be easily replaced by fee-for-sen/ice income, ensuring a self-sustaining future for MIPC facilities. It is envisioned that increasing collaboration among LSU and TNPRC scientists, as evidenced by the presence of three collaborative projects between LSU-SVM and TNPRC scientists and a jointly hired faculty member (recruitment in process), will lead to enhancement of know-how and support functions for all MIPC facilities. Certain functions ofthe MIPC are unique to either location. The MIPC aims to 1) Provide access to specialized equipment and molecular immunopathological and microscopy expertise to CEIDR researchers. 2) Train investigators and their staff in the theory and use of technologies available in MIPC. 3) Promote the development and use of new technologies and assays that can be used to characterize pathogen-host interactions in vitro and in experimental animal infections (small animals and NHP).

在COBRE“实验传染病研究中心”的前两个阶段， （CEIDR）"，CEIDR分子免疫病理学核心（MIPC）利用多个核心的支持， LSU和杜兰国家灵长类动物研究中心（TNPRC）的设施和设备，以支持 NIH资助的传染病研究。原来的MIPC保持不变，除了两个专门的 处理分子生物学、NGS和生物信息学的职能现在由Genelab承担， 蛋白质和抗体的生产和蛋白质表征由PCL涵盖。MIPC现在利用 并协调ISU-SVM和TNPRC的流式细胞术，病理学和显微镜检查的核心活动。 所有这三项活动都构成了已建立的核心实验室，它们作为一个成本中心联盟， ISU-SVM和TNPRC。MIPC单元很可能在未来得到维持，因为目前， 提供高达80%的人员费用，而TNPC设施由NIH灵长类中心提供支持 基本补助金和强劲的服务费收入。路易斯安那州立大学的设施主要集中在啮齿动物和节肢动物 热带太平洋区域中心的设施几乎完全侧重于非人灵长类动物的研究支助。 因此，预计COBRE第111阶段为这些设施提供的资金将很容易被以下资金取代： 服务费收入，确保MIPC设施的自我维持未来。据估计，增加 路易斯安那州立大学和TNPRC科学家之间的合作，证明了三个合作的存在 LSU-SVM和TNPRC科学家之间的项目和联合聘请的教员（招聘 这一进程）将加强MIPC所有设施的专门知识和支助职能。某些 MIPC的功能在这两个地方都是独一无二的。MIPC的目标是：1）提供专业的 设备和分子免疫病理学和显微镜专业知识CEIDR研究人员。2)火车 调查人员及其工作人员在理论和使用技术的MIPC。3)推进 开发和使用可用于鉴定病原体-宿主关系的新技术和测定法 体外和实验动物感染（小动物和NHP）中的相互作用。