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Neural Mechanisms for Early Development of Pervasive Anger and Irritability

普遍愤怒和易怒早期发展的神经机制

基本信息

批准号：
8656145
负责人：
Susan B Perlman
金额：
$ 15.4万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-20 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8656145
关键词：
9 year old Affective Age Amygdaloid structure Anger Anterior Attention Behavior Behavioral Biological Markers Brain Caregivers Categories Child Child Behavior Child Behavior Checklist Child Psychiatry Clinic Clinical Clinical Services Clinical Skills DSM-V Development Diagnosis Diagnostic Disease Dorsal Emotional Emotions Functional Magnetic Resonance Imaging Functional disorder Future Goals Knowledge Measures Mediating Mental Health Mood Disorders Nature Parents Psychiatric Diagnosis Psychiatrist Psychopathology Publications Questionnaires Relative (related person)Reporting Research Research Training Risk Sampling Scanning Schedule School-Age Population Scientist Secure Severities Staging Support System Symptoms System Therapeutic Intervention Training affective neuroscience base behavior measurement career clinical Diagnosis clinical care cognitive neuroscience developmental psychology early onset emotion regulation experience meetings neuroimaging neuromechanism novel diagnostics psychosocial relating to nervous system research clinical testing teacher

项目摘要

DESCRIPTION (provided by applicant): The goal of this research is to use functional magnetic resonance imaging (fMRI) to study the neural basis of attentional dyscontrol and emotion dysregulation in a sample of young children (ages 6-9) who are displaying early onset pervasive anger and irritability. These symptoms represent a significant mental health concern that some say requires a new diagnostic category in the DSM-V revision in order to secure the research and clinical services that these children require. The proposed study will be the first to examine brain mechanisms for attentional dyscontrol and emotion dysregulation, which signify key behavioral deficits, in these young school-age, unmedicated children upon first clinic presentation. Obtaining these measures of functional abnormalities in attentional control and emotion regulatory neural systems in young children presenting with pervasive anger and irritability relative to age-matched healthy counterparts will first help us to identify which children show greater levels of dysfunction within these neural systems. It is also a first step toward the longer term goal of examining the extent to which these neural system abnormalities may represent biological markers that can help distinguish relevant developmental trajectories of psychopathology, so that different treatments can be applied at this early stage of symptomatology. Well-validated experimental paradigms, including one paradigm developed by the PI, and behavioral measures will be employed. Primary analyses will probe the neural activity within specific regions related to attentional dyscontrol and emotion dysregulation, and connectivity amongst them, in order to define brain deficits for this illness. Exploratory analyses will examine the extent to which these neural system abnormalities may predict symptom severity and clinical diagnosis by correlating activity in these neural systems with parent reported symptom severity and clinician diagnostic report. Finally, long term plans for this research include a future proposal to complete a longitudinal neuroimaging study in which young children presenting with pervasive anger and irritability will be scanned yearly to increase our understanding of the neural and clinical trajectories of these symptoms. The P.I. already possesses general knowledge of developmental psychology with specific emphasis on emotional development and has extensive experience in the neuroimaging of young children, but lacks the clinical skill set necessary to become an independent scientist in the field of child psychiatry. Therefore, the proposed training plan is aimed at acquiring the relevant clinical skill set necessary to conduct neurodevelopmental research regarding early risk for child psychopathology. The P.I. will complete coursework, train with experts in the field, and author empirical and theoretical publications in order to develop an understanding of child clinical issues. This cross-disciplinary research and training plan, therefore, allows for a stepwise approach to a career in the cognitive and affective neuroscience of child psychopathology.

描述(申请人提供)：这项研究的目标是使用功能磁共振成像(FMRI)来研究注意控制障碍和情绪障碍的神经基础，样本为6-9岁的幼儿，他们表现出早期发作的普遍愤怒和易怒。这些症状代表了一个重要的心理健康问题，一些人说，需要在DSM-V修订版中增加一个新的诊断类别，以确保这些儿童所需的研究和临床服务。这项拟议的研究将首次检查这些学龄儿童首次出现临床症状时未服用药物的儿童的注意力控制失调和情绪失调的大脑机制，这意味着关键的行为缺陷。与年龄匹配的健康儿童相比，在表现出普遍愤怒和易怒的幼儿中，获得注意力控制和情绪调节神经系统功能异常的这些测量将首先帮助我们确定哪些儿童在这些神经系统中表现出更大程度的功能障碍。这也是朝着更长期目标迈出的第一步，即检查这些神经系统异常在多大程度上可能代表有助于区分相关精神病理学发展轨迹的生物标记物，以便在症状学的早期阶段应用不同的治疗方法。将采用经过充分验证的实验范式，包括由PI开发的一个范式和行为测量。初步分析将探索与注意力控制障碍和情绪调节障碍相关的特定区域内的神经活动，以及它们之间的联系，以确定这种疾病的大脑缺陷。探索性分析将通过将这些神经系统的活动与父母报告的症状严重程度和临床诊断报告相关联，检查这些神经系统异常可以预测症状严重程度和临床诊断的程度。最后，这项研究的长期计划包括一项未来的建议，即完成一项纵向神经成像研究，在该研究中，将每年对表现出普遍愤怒和易怒的幼儿进行扫描，以增加我们对这些症状的神经和临床轨迹的了解。私家侦探已经具备了发展心理学的常识，特别注重情绪发展，在幼儿的神经成像方面也有丰富的经验，但缺乏成为儿童精神病学领域独立科学家所需的临床技能。因此，拟议的培训计划旨在获得必要的相关临床技能，以进行关于儿童精神病理学早期风险的神经发育研究。P.I.将完成课程作业，与该领域的专家进行培训，并撰写经验性和理论性出版物，以发展对儿童临床问题的理解。因此，这种跨学科的研究和培训计划允许逐步进入儿童精神病理学的认知和情感神经科学的职业生涯。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neuroimaging in child clinical populations: considerations for a successful research program.

儿童临床人群的神经影像学：成功研究计划的考虑因素。

DOI：
10.1016/j.jaac.2012.09.008
发表时间：
2012
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry
影响因子：
13.3
作者：
Perlman,SusanB
通讯作者：
Perlman,SusanB

Emotional face processing in pediatric bipolar disorder: evidence for functional impairments in the fusiform gyrus.

DOI：
10.1016/j.jaac.2013.09.004
发表时间：
2013-12
期刊：
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
影响因子：
13.3
作者：
Perlman, Susan B.;Fournier, Jay C.;Bebko, Genna;Bertocci, Michele A.;Hinze, Amanda K.;Bonar, Lisa;Almeida, Jorge R. C.;Versace, Amelia;Schirda, Claudiu;Travis, Michael;Gill, Mary Kay;Demeter, Christine;Diwadkar, Vaibhav A.;Sunshine, Jeffrey L.;Holland, Scott K.;Kowatch, Robert A.;Birmaher, Boris;Axelson, David;Horwitz, Sarah M.;Arnold, L. Eugene;Fristad, Mary A.;Youngstrom, Eric A.;Findling, Robert L.;Phillips, Mary L.
通讯作者：
Phillips, Mary L.

Developmental Differences in Affective Representation Between Prefrontal and Subcortical Structures.