Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health

青春期的日常经验和成人健康早期风险的生物标志物

• 批准号: 8720550
• 负责人: ANDREW J FULIGNI
• 金额: $ 37.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-19 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8720550
• 关键词: 20 year old; Address; Adolescence; Adolescent; Adrenal Glands; Adult; Age-Years; American; Asian Americans; Asians; Automobile Driving; Behavior; Behavior assessment; Biological; Biological Markers; Biology; Blood; Blood Pressure; Blood specimen; Body mass index; Cardiovascular Diseases; Caregivers; Chinese People; Cholesterol; Chronic; Conflict (Psychology); Cytokine Gene; Data; Demographic Survey; Development; Early identification; Education; Emotions; Ethnic group; European; Event; Family; Gene Expression; Genes; Health; Health behavior; High Density Lipoprotein Cholesterol; Hydrocortisone; Hypothalamic structure; Income; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Interview; Knowledge; Latino; Link; Longitudinal Studies; Measures; Mexican; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Parents; Participant; Persons; Pharmaceutical Preparations; Physical activity; Pituitary Gland; Plasma; Play; Population; Prevention; Process; Proteins; Reporting; Research; Risk; Risk Factors; Role; Salivary; Sampling; Signal Pathway; Sleep; Smoking; Social Conditions; Source; Spottings; Surveys; Testing; Time; United States; Waist-Hip Ratio; Wrist; base; diaries; drinking; emotional distress; experience; indexing; middle age; peripheral blood; public health relevance; social; socioeconomics; stem; stressor

DESCRIPTION (provided by applicant): Despite calls for the identification of early risk factors for the development of chronic health conditions, there has been little longitudinal research on biomarkers of health that has been conducted in persons younger than 25 years of age. In addition, there is only a minimal understanding of how biological indices of early risk for adult health develop among adolescents with Latin American and Asian backgrounds, the two fastest rising ethnic groups in the United States, who are at differential risk for adverse health outcomes as compared to European Americans. An understanding of these processes is necessary for the development of ethnically and culturally relevant prevention efforts. We propose a 3-wave longitudinal study of adolescents and their caregivers from Mexican, Chinese and European backgrounds in order to assess the impact of daily experience on biological indicators of early risk for adult health. Our focus on daily experience stems from the need to identify the mechanisms by which global social factors identified in demographic surveys, such as lower education and income, play themselves out in individuals' daily lives. Daily experiences such as social conflict, excessive demands, emotional distress, threat, and sleep behaviors have been shown to be linked to both global risk factors and multiple biological indices of health risk among adults. The project will include both intensive behavioral assessments and detailed biological markers of health risk from both adolescents and their parents in order to address the following specific aims: (1) describe the development during adolescence of biological indices of early risk for adult health; (2) assess the role of daily experience in the development of early health risk; (3) examine the existence of ethnic disparities in early health risk; and (4) explore the role of potential protective factors in the development of early health risk. Approximately 540 pairs of adolescents and primary caregivers (180 from each ethnic group) will be assessed when the adolescents are approximately 15-16, 17-18, and 19-20 years of age. Each year, both adolescents and caregivers will participate in interviews that include measures of global social factors such as socioeconomic background and potential protective factors such as social connectedness. Participants will report daily experiences using a nightly diary checklist for 9 consecutive days. Salivary cortisol will be obtained at 4 time points each day for 4 of these days in order to analyze HPA activity, and participants will wear wrist actigraphs for the same 4 days to measure objective sleep behaviors. Blood pressure, BMI, and waist/hip ratio will be assessed, and dried blood spots will be obtained for the assessment of c-reactive-protein (CRP), cholesterol, and high density lipoproteins (HDL). Finally, peripheral blood samples will be provided by a subsample of 120 families for the assessment of plasma interleukin-6 (IL-6), a pro-inflammatory cytokine, and for gene expression analyses of molecular signaling pathways driving inflammatory biology.

描述（由申请人提供）：尽管呼吁确定慢性健康状况发展的早期风险因素，但在25岁以下人群中进行的健康生物标志物的纵向研究很少。此外，对于拉丁美洲和亚洲背景的青少年成年健康早期风险的生物学指标是如何发展的了解很少，这是美国增长最快的两个种族群体，与欧洲裔美国人相比，他们面临着不良健康结果的不同风险。了解这些过程对于开展与种族和文化有关的预防工作是必要的。我们提议对来自墨西哥、中国和欧洲背景的青少年及其照顾者进行三波纵向研究，以评估日常经历对成年健康早期风险生物学指标的影响。我们对日常经验的关注源于需要确定在人口调查中确定的全球社会因素（如较低的教育和收入）在个人日常生活中发挥作用的机制。社会冲突、过度要求、情绪困扰、威胁和睡眠行为等日常经历已被证明与成人健康风险的全球风险因素和多种生物学指标有关。该项目将包括对青少年及其父母的健康风险进行深入的行为评估和详细的生物学标记，以实现以下具体目标：(1)描述青春期早期成年健康风险生物学指标的发展情况；(2)评估日常经历在早期健康风险发展中的作用；(3)检验早期健康风险存在的种族差异；(4)探讨潜在保护因素在早期健康风险发展中的作用。在青少年大约15-16岁、17-18岁和19-20岁时，将对大约540对青少年和主要照顾者（每个族裔180对）进行评估。每年，青少年和照顾者都将参加访谈，其中包括衡量全球社会因素，如社会经济背景和潜在的保护因素，如社会联系。参与者将连续9天使用夜间日记清单报告每天的经历。为了分析HPA活动，研究人员将在4天内每天4个时间点采集唾液皮质醇，参与者将在同样的4天内佩戴手腕活动仪来测量客观睡眠行为。评估血压、BMI和腰臀比，并获得干血点以评估c反应蛋白（CRP）、胆固醇和高密度脂蛋白（HDL）。最后，外周血样本将由120个家族的亚样本提供，用于评估血浆白细胞介素-6 (IL-6)，一种促炎细胞因子，以及驱动炎症生物学的分子信号通路的基因表达分析。