UCSF Older Americans Independence Center

描述（由申请人提供）：晚期残疾，定义为日常活动需要帮助，对患者，家庭和社会来说是常见的，负担沉重的和昂贵的。晚年残疾受医疗脆弱性（包括共病、医疗护理、药物、程序、神经精神疾病和行为方面）、社会脆弱性（社会支持、财政资源、沟通和识字以及种族）及其相互作用的影响。UCSF OAIC将把工作重点放在解决这些弱势人群中晚期残疾的预测因素，特征和结果上，这些弱势人群的残疾或死亡风险增加。UCSF OAIC的首要目标是通过以下目标改善弱势老年人的医疗保健和生活质量：1）通过作为汇集学者和利用资源的中心，催化UCSF弱势老年人的残疾研究; 2）提供有形的，高价值的支持，以资助项目在加州大学旧金山分校，刺激对残疾的新研究，并导致新的研究机会，为高级和初级研究人员; 3）支持试点研究，加速科学和导致研究资金在晚年残疾; 4）确定老年医学研究的未来领导人，并支持他们的职业发展资金和特殊的指导; 5）建立一个促进跨学科合作的领导和行政结构，使OAIC大于其各部分的总和。为了实现其目标，UCSF OAIC将在PI Ken Covinsky的领导下支持5个核心。LAC将为整个UCSF OAIC提供领导支持。RCDC将利用RCDC学者和高级学者计划来识别，支持和培养将成为老龄化研究国家领导人的初级研究人员。RDAC将加强对外部资助赠款（外部项目）、OAIC试点项目和RCDC项目的分析，并将开展一个发展项目。DMAC将帮助研究人员设计具有残疾研究理想数据源的研究，支持研究人员在正在进行的研究中增加残疾指标， 并进行DP。该PESC将促进创新和有前途的研究，提高我们的理解的方式，可以减轻晚年残疾，并导致投资回报率的资金。通过评估医疗和社会脆弱性如何促进残疾过程，UCSF OAIC将为我们理解如何最好地照顾有残疾风险或发展残疾的老年人，推进研究和指导临床实践做出有意义的贡献。

DESCRIPTION (provided by applicant): Late-life disability, defined as needing help with daily activities, is common, burdensome, and costly to patients, families, and society. Late-life disability is influenced by medical vulnerabilities (including comorbid illnesses, aspects of medical care, medicines, procedures, neuropsychiatric conditions, and behaviors), social vulnerabilities (social supports, financial resources, communication and literacy, and ethnicity), and their interaction. The UCSF OAIC will focus its efforts on addressing predictors, characteristics, and outcomes of late-life disability in these vulnerable populations at increased risk for disability or death. The overriding goal of the UCSF OAIC will be to improve the health care and quality of life of vulnerable older adults with or at risk for disability through the follwing aims: 1) Catalyze research on disability in vulnerable older persons at UCSF by serving as a hub that brings together scholars and leverages resources; 2) Provide tangible, high-value support to funded projects at UCSF that stimulate new research on disability, and lead to new research opportunities for senior and junior investigators; 3) Support pilot studies that accelerat science and lead to research funding in late life disability; 4) Identify the future leaders of geriatrics research and support them with career development funding and exceptional mentoring; and 5) Develop a leadership and administrative structure that spurs interdisciplinary collaboration, making the OAIC greater than the sum of its parts. To achieve its aims, the UCSF OAIC will support 5 Cores under the leadership of PI Ken Covinsky. The LAC will provide leadership support for the entire UCSF OAIC. The RCDC will utilize the RCDC Scholars and Advanced Scholars Programs to identify, support, and nurture junior investigators who will become national leaders in aging research. The RDAC will enhance analyses of extramurally funded grants (External Projects), OAIC pilot projects, and RCDC projects, and will conduct a Development Project (DP). The DMAC will help investigators design studies with data sources ideal for disability research, support investigators adding disability measures to ongoing studies, and conduct a DP. The PESC will promote innovative and promising research that enhances our understanding in ways that can mitigate late-life disability, and that leads to ROI funding. By evaluating how medical and social vulnerabilities contribute to the disablement process, the UCSF OAIC will make a meaningful contribution to our understanding of how to best care for older adults who are at risk for or developing disability, advance research and guide clinical practice.