University of Iowa Institute for Clinical and Translational Science

描述(由申请者提供)：爱荷华大学(Ul)临床与翻译科学研究所(ICTS)非常适合实现CTSA计划的最终目标--促进研究从长凳到床边、到社区、到个别患者和回来的真正转化。自成立以来，ICTS成功地聘请了来自UL所有11所学院--医学、公共卫生、牙科、护理、药学、工程、文理、教育、法律、商业和研究生--的研究人员、实习生和研究人员。ICTS还与爱荷华州立大学、退伍军人管理局中西部医疗保健网络、爱荷华州初级保健协会以及临床网络合作，为农村和其他服务不足的人群提供护理，并支持T2-T4翻译研究。这一应用将进一步增强我们的基础设施，促进更复杂的翻译研究，使ICTS在改进监管程序方面发挥更大的机构作用，并使我们的合作组织更容易获得临床研究支持和数据仓库，以及其他CTSA机构对我们独特资源的访问。与这些努力相关的四个目标是：1)通过以下方式促进创新的T1-T4科学：支持跨学科高影响力研究的新试点计划；促进BASCH、临床和以人群为基础的科学家之间的新合作；改善团队科学的环境；以及药物发现和开发方面的新计划。2)通过以下方式提高研究效率：增加受试者招募和降低数据收集成本的新方法；采用共享的IRB安排和总合同；支持NIH多站点研究网络；以及将项目评估数据与资源分配决策紧密联系起来。3)与以下机构建立和培育伙伴关系：UL研究中心，以利用资源并避免服务重复；区域医疗保健提供者，以扩大T2-T4研究的机会；其他CTSA机构，以传播新的UL产品，并引入有前途的科学和管理方法；以及私营生物技术公司。4)构建动态的教育、服务和信息学基础设施，以：支持跨职业范围的翻译调查人员的培训需求；支持T1-T4调查人员的研究服务需求；并实现高效、安全和可靠的研究。

DESCRIPTION (provided by applicant): The University of Iowa (Ul) Institute for Clinical and Translational Science (ICTS) is ideally positioned to accomplish the ultimate goal of the CTSA initiative - to promote the true translation of research from bench to bedside, to community, to individual patient, and back. Since its creation, the ICTS has successfully engaged investigators, trainees, and research staff from all 11 Ul colleges -- Medicine, Public Health, Dentistry, Nursing, Pharmacy, Engineering, Liberal Arts and Sciences, Education, Law, Business, and Graduate. The ICTS also crafted collaborations with Iowa State University, the VA Midwest Health Care Network, the Iowa Primary Care Association, and clinical networks that care for rural and other underserved populations and that support T2 - T4 translational studies. This application will further enhance our infrastructures, facilitate more sophisticated translational research, position the ICTS to assume an even greater institutional role in improving regulatory procedures, and increase access of our collaborating organizations to clinical research support and data warehousing and access of other CTSA institutions to our unique resources. The four aims related to these efforts are to: 1) Catalyze innovative T1 - T4 Science through: new pilot programs to support interdisciplinary high impact research; facilitation of new collaborations between bench, clinical, and population-based scientists; enhancement of the environment for team science; and a new program in drug discovery and development. 2) Improve research efficiency through: novel approaches to increase subject recruitment and decrease data collection costs; adoption of shared IRB arrangements and master contracts; supporting NIH multi-site research networks; and tightly linking program evaluation data to decisions about resource allocation. 3) Create and nurture partnerships with: Ul research centers to leverage resources and avoid duplication of services; regional healthcare providers to expand opportunities for T2 - T4 research; other CTSA institutions to disseminate novel Ul products and import promising scientific and administrative approaches; and private biotechnology firms. 4) Build dynamic educational, service, and informatics infrastructures to: support the training needs of translational investigators across the career spectrum; support the research services needs of T1 - T4 investigators; and enable highly productive, safe and secure research.