University of Iowa Institute for Clinical and Translational Science

描述（由申请人提供）：爱荷华大学临床与转化科学研究所（ICTS）的理想定位是实现CTSA倡议的最终目标-促进研究从实验室到床边，到社区，到个体患者，再到返回的真正转化。自成立以来，信息通信技术中心已成功地聘请了来自大学所有11个学院——医学、公共卫生、牙科、护理、药学、工程、文科和理科、教育、法律、商业和研究生院的调查人员、学员和研究人员。ict还与爱荷华州立大学、VA中西部卫生保健网络、爱荷华初级保健协会以及为农村和其他服务不足人群提供服务并支持T2 - T4转化研究的临床网络进行了合作。这一应用程序将进一步加强我们的基础设施，促进更复杂的转化研究，使ict在改进监管程序方面发挥更大的机构作用，并增加我们的合作组织对临床研究支持和数据仓库的访问，以及其他CTSA机构对我们独特资源的访问。与这些努力相关的四个目标是：1)通过新的试点项目来促进创新的T1 - T4科学，以支持跨学科的高影响力研究；促进实验室、临床和基于人群的科学家之间的新合作；改善团队科学的环境；还有一个药物发现和开发的新项目。2)通过以下方式提高研究效率：采用新颖的方法增加受试者招募，降低数据收集成本；采用共同的内部审核安排和主合同；支持NIH多站点研究网络；并将项目评估数据与资源分配决策紧密联系起来。3)与以下研究中心建立和培育合作伙伴关系：利用资源，避免重复服务；区域医疗保健提供者扩大T2 - T4研究的机会；其他CTSA机构推广新颖的Ul产品和引进有前途的科学和管理方法；以及私人生物技术公司。4)建立动态的教育、服务和信息基础设施，以支持跨职业范围的转化研究人员的培训需求；支持T1 - T4调查员的研究服务需求；使高效、安全、可靠的研究成为可能。

DESCRIPTION (provided by applicant): The University of Iowa (Ul) Institute for Clinical and Translational Science (ICTS) is ideally positioned to accomplish the ultimate goal of the CTSA initiative - to promote the true translation of research from bench to bedside, to community, to individual patient, and back. Since its creation, the ICTS has successfully engaged investigators, trainees, and research staff from all 11 Ul colleges -- Medicine, Public Health, Dentistry, Nursing, Pharmacy, Engineering, Liberal Arts and Sciences, Education, Law, Business, and Graduate. The ICTS also crafted collaborations with Iowa State University, the VA Midwest Health Care Network, the Iowa Primary Care Association, and clinical networks that care for rural and other underserved populations and that support T2 - T4 translational studies. This application will further enhance our infrastructures, facilitate more sophisticated translational research, position the ICTS to assume an even greater institutional role in improving regulatory procedures, and increase access of our collaborating organizations to clinical research support and data warehousing and access of other CTSA institutions to our unique resources. The four aims related to these efforts are to: 1) Catalyze innovative T1 - T4 Science through: new pilot programs to support interdisciplinary high impact research; facilitation of new collaborations between bench, clinical, and population-based scientists; enhancement of the environment for team science; and a new program in drug discovery and development. 2) Improve research efficiency through: novel approaches to increase subject recruitment and decrease data collection costs; adoption of shared IRB arrangements and master contracts; supporting NIH multi-site research networks; and tightly linking program evaluation data to decisions about resource allocation. 3) Create and nurture partnerships with: Ul research centers to leverage resources and avoid duplication of services; regional healthcare providers to expand opportunities for T2 - T4 research; other CTSA institutions to disseminate novel Ul products and import promising scientific and administrative approaches; and private biotechnology firms. 4) Build dynamic educational, service, and informatics infrastructures to: support the training needs of translational investigators across the career spectrum; support the research services needs of T1 - T4 investigators; and enable highly productive, safe and secure research.