The University of Iowa Clinical and Translational Science Award

爱荷华大学临床和转化科学奖

基本信息

批准号：
8995815
负责人：
GARY E ROSENTHAL
金额：
$ 352.86万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-14 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8995815
关键词：
Academic Medical Centers Academy Acceleration Adoption Affect American Area Arts Award Behavioral Caring Child Child Abuse Clinic Clinical Clinical Data Clinical Research Clinical Sciences Clinical Trials Collaborations Communication Communities Community Practice Computerized Medical Record Data Development Dimensions Discipline Disease Distance Learning Elderly Enabling Factors Epidemiologic Studies Estrogens Faculty Family Physicians Fostering Funding Genetic Goals Grant Health Health Alliance Health system Healthcare Heart Hereditary Disease Hospitals Human Subject Research Individual Informatics Institute of Medicine (U.S.)Institutes Institution Iowa Knowledge Lead Learning Link Locales Longevity Longitudinal Studies Measurable Medical Mental disorders Methods Mission Modeling Multicenter Neonatal Research Network Patients Persons Pharmacists Phase Physicians Population Positioning Attribute Postmenopause Process Recruitment Activity Research Research Design Research Infrastructure Research Methodology Research Personnel Resources Risk Factors Rural Rural Community Rural Health Rural Population School Nursing Science Shapes Site Solutions Stable Populations Statistical Methods System Technology Testing Textiles Touch sensation Training Translating Translational Research Translations Trust United States National Academy of Sciences United States National Institutes of Health Universities Vision Woman Women&apos s Health Work base cardiovascular risk factor catalyst clinical practice community organizations critical access hospital evidence base functional decline health care delivery improved innovation interest medical specialties meetings member multidisciplinary next generation novel novel strategies population health programs public health relevance social working group

项目摘要

DESCRIPTION (provided by applicant): The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) was established by the Board of Regents to realize three objectives - first, to lead the development of translational science at the UI; second, to advance translational science as a distinct academic discipline; and third, to disseminate capacities in translational science across the State of Iowa. This mandate enabled us to tackle large problems affecting translational science that required institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well-trained clinical and translational researchers. The task for this new application is extend our impact and to build a model learning health system (LHS) to integrate research and practice across the lifespan and across the T0 - T4 translational spectrum with the intent of accelerating the translation of discovery to improved population health. Becoming an exemplary next generation CTSA that can produce logarithmic acceleration requires refocusing many current programs and creating new resources to: (1) promote workforce development; (2) systematically engage stakeholders; (3) integrate translational research along several distinct dimensions; and (4) spur innovation. The milestones for this application have a special focus on rural health, community engagement, research- practice integration, clinical research efficiency, innovative statistical methods, and rare genetic diseases. In addition, some of the milestones reflect our interest in working with other CTSA hubs to empirically test different approaches and for developing an evidence base of proven strategies for accelerating translation that can be more broadly disseminated. In this way we can incentivize the development and adoption of new methods and promote innovation in everyday research processes throughout Iowa and beyond our borders. In particular, we will engage investigators and stakeholders across Iowa using approaches that overcome the geographic barriers in a rural state and that build on our established community practice networks of family physicians, clinics, school nurses and pharmacists, with particular examples related to lifespan research and child abuse. To build this LHS we will engage and train undergraduates, pre and postdoctoral trainees, established investigators research staff and clinicians at the UI and in the newly formed UI Health Alliance (an integrated network of 58 hospitals, 175 clinics, critical access hospitals in rural communities regional medical centers, and the UI) which touches 60% of the population in Iowa to drive clinical and translational discovery and to change healthcare practice in a variety of clinical settings.

描述（由应用程序提供）：董事会建立了爱荷华大学（UI）的临床与转化科学研究所（ICT），以实现三个目标 - 首先，领导UI的转化科学发展；其次，将转化科学作为一门独特的学科发展；第三，在爱荷华州传播转化科学的能力。这项任务使我们能够解决影响需要机构解决方案的转化科学的大型问题，例如改造人类受试者研究的监管过程，开发用于整合电子医疗记录和其他医疗保健数据的信息基础架构，与社区组织建立双向关系，并使训练有素的临床和翻译临床和翻译研究人员复兴。这项新应用程序的任务扩大了我们的影响，并建立模型学习卫生系统（LHS），以整合整个寿命和T0 -T4转化频谱的研究和实践，并加快发现发现以改善人口健康的意图。成为可以产生对数加速的下一代CTSA的典范，需要重新调整许多当前程序并创造新的资源以：（1）促进劳动力发展；（2）系统地吸引利益相关者；（3）沿几个不同维度的综合翻译研究；（4）刺激创新。该应用程序的里程碑特别关注粗糙的健康，社区参与，研究实践融合，临床研究效率，创新的统计方法和罕见的遗传疾病。此外，一些里程碑反映了我们对与其他CTSA枢纽合作的兴趣，以经验测试不同的方法，并开发了可以更广泛传播的可加速翻译策略的证据基础。通过这种方式，我们可以激励新方法的发展和采用，并在整个爱荷华州及我们的边界之外的每天研究过程中促进创新。特别是，我们将使用在崎rough的状态下克服地理障碍的方法与爱荷华州各地的调查人员和利益相关者互动，这些方法建立在我们既定的家庭医师，诊所，学校护士和药剂师的社区实践网络上，并具有与寿命研究和儿童虐待有关的特别例子。为了构建该LHS，我们将在UI和新成立的UI Health Alliance（175家综合医院，175个临床综合网络，175个临床，关键的访问医院的关键访问医疗中心和UI的临床范围内转换为60％的人群中的人群中，在UI和新成立的UI Health Alliance（175个综合医院，175个临床的综合网络，175个临床医院）中，在UI和新成立的UI Health Alliance（175个综合医院，175个医院的综合网络，175个临床的综合网络，175个临床的综合网络）中，成立的研究人员和临床医生将参与并培训本科生的研究人员和临床医生。在各种临床环境中练习。