The University of Iowa Clinical and Translational Science Award

 描述（由申请人提供）：爱荷华州大学（UI）的临床和转化科学研究所（ICTS）由董事会成立，旨在实现三个目标-第一，领导UI的转化科学发展;第二，推进转化科学作为一个独特的学科;第三，在整个爱荷华州传播转化科学的能力。这项任务使我们能够解决影响转化科学的大问题，这些问题需要制度性的解决方案，例如改变人类受试者研究的监管流程，开发用于整合电子病历和其他医疗保健数据的信息学基础设施，与社区组织建立双向关系，以及振兴训练有素的临床和转化研究人员的管道。这项新应用的任务是扩大我们的影响，并建立一个模型学习健康系统（LHS），以整合整个生命周期和T0 - T4转化谱的研究和实践，旨在加速将发现转化为改善人口健康。成为一个可以产生对数加速的示范性下一代CTSA需要重新关注许多当前的计划并创造新的资源：（1）促进劳动力发展;（2）系统地参与利益相关者;（3）沿着沿着几个不同的维度整合转化研究;（4）刺激创新。 该应用程序的里程碑特别关注农村健康，社区参与，研究-实践整合，临床研究效率，创新统计方法和罕见遗传疾病。此外，一些里程碑反映了我们有兴趣与其他CTSA中心合作，对不同的方法进行经验测试，并为加速翻译开发一个可以更广泛传播的证据库。通过这种方式，我们可以激励新方法的开发和采用，并在整个爱荷华州和我们的边界以外的日常研究过程中促进创新。特别是，我们将参与整个爱荷华州的调查人员和利益相关者使用的方法，克服了在农村国家的地理障碍，并建立在我们建立的家庭医生，诊所，学校护士和药剂师的社区实践网络，特别是与寿命研究和虐待儿童有关的例子。为了建立这个LHS，我们将在UI和新成立的UI健康联盟中参与和培训本科生，博士前和博士后学员，既定的研究人员和临床医生（一个由58家医院、175家诊所、农村社区的关键医院和区域医疗中心组成的综合网络，和UI），涉及爱荷华州60%的人口，以推动临床和转化发现，并改变各种临床环境中的医疗保健实践。

 DESCRIPTION (provided by applicant): The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) was established by the Board of Regents to realize three objectives - first, to lead the development of translational science at the UI; second, to advance translational science as a distinct academic discipline; and third, to disseminate capacities in translational science across the State of Iowa. This mandate enabled us to tackle large problems affecting translational science that required institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well-trained clinical and translational researchers. The task for this new application is extend our impact and to build a model learning health system (LHS) to integrate research and practice across the lifespan and across the T0 - T4 translational spectrum with the intent of accelerating the translation of discovery to improved population health. Becoming an exemplary next generation CTSA that can produce logarithmic acceleration requires refocusing many current programs and creating new resources to: (1) promote workforce development; (2) systematically engage stakeholders; (3) integrate translational research along several distinct dimensions; and (4) spur innovation. The milestones for this application have a special focus on rural health, community engagement, research- practice integration, clinical research efficiency, innovative statistical methods, and rare genetic diseases. In addition, some of the milestones reflect our interest in working with other CTSA hubs to empirically test different approaches and for developing an evidence base of proven strategies for accelerating translation that can be more broadly disseminated. In this way we can incentivize the development and adoption of new methods and promote innovation in everyday research processes throughout Iowa and beyond our borders. In particular, we will engage investigators and stakeholders across Iowa using approaches that overcome the geographic barriers in a rural state and that build on our established community practice networks of family physicians, clinics, school nurses and pharmacists, with particular examples related to lifespan research and child abuse. To build this LHS we will engage and train undergraduates, pre and postdoctoral trainees, established investigators research staff and clinicians at the UI and in the newly formed UI Health Alliance (an integrated network of 58 hospitals, 175 clinics, critical access hospitals in rural communities regional medical centers, and the UI) which touches 60% of the population in Iowa to drive clinical and translational discovery and to change healthcare practice in a variety of clinical settings.