NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 8641711
• 负责人: CHRISTIANE E DAMMANN
• 金额: $ 0.76万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8641711
• 关键词: Admission activity; Area; Beds; Birth; Boston; Caring; Catchment Area; Childhood; Clinical; Clinical Investigator; Clinical Research; Clinical Services; Clinical Trials; Collaborations; Databases; Development; Discipline of obstetrics; Doctor of Philosophy; Enrollment; Environmental Exposure; Expenditure; Faculty; Genomics; Gestational Age; Goals; Gynecology; Health Services Research; Hospitals; Individual; Infant; Institutes; Instruction; Judgment; Leadership; Massachusetts; Medical; Medical center; Medicine; Monitor; Morbidity - disease rate; Mothers; Multicenter Neonatal Research Network; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Newborn Infant; Nurseries; Ophthalmology; Patients; Pediatric Hospitals; Pediatric Surgical Procedures; Perinatal; Population; Principal Investigator; Productivity; Protocols documentation; RNA; Recording of previous events; Records; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Proposals; Resources; Safety; Salivary; Science; Site; Societies; Source; System; Testing; Translational Research; Universities; burden of illness; computerized; data management; design; experience; fetal medicine; flexibility; follow-up; high risk infant; improved; innovation; member; mortality; novel strategies; patient population; programs; public health relevance; research study; success

DESCRIPTION (provided by applicant): This competing renewal application aims to demonstrate that the Floating Hospital for Children at Tufts Medical Center has the patient population, faculty and staff expertise, clinical services, research resources, and enrollment and follow-up successes to continue as an outstanding and productive member of the NICHD's Neonatal Research Network (NRN). Tufts has a long history of leadership in collaborative multicenter clinical research studies, as exemplified by one of the highest track records in the NRN for both enrollment (55%) and follow-up (97%) in the recently completed SUPPORT trial. Tufts draws upon an ethnically and geographically diverse neonatal population that receives its care in one of the largest level III nurseries in Boston. Approximately 600 infants (70% inborn) are admitted annually to its 41-bed NICU. In addition, both the Newborn Medicine and Maternal-Fetal Medicine programs have well-established affiliations with regional hospitals that result in referrals from a catchment area of 19,000 annual births. The Principal Investigator, Dr. Ivan D. Frantz III, and the Division of Newborn Medicine's faculty, have shown that they have the organizational strengths and research experience to design, implement, and actively participate in clinical trials. Our application is enhanced by an innovative concept application that incorporates a noninvasive genomic approach to explain the mechanisms underlying clinical variability in newborn infants of similar gestational ages and environmental exposures through analysis of salivary RNA. The Tufts program has broad institutional support and outstanding resources for the conduct of clinical research, data management and safety monitoring. Furthermore, the recent development of a Clinical Translational Science Institute (CTSI) at Tufts University and a Mother Infant Research Institute at Tufts Medical Center provide both infrastructure and additional collaborations.

描述(由申请人提供)：这份竞争性续签申请旨在证明塔夫茨医疗中心的浮动儿童医院拥有患者人数、教职员工专业知识、临床服务、研究资源以及注册和后续成功，能够继续成为NICHD新生儿研究网络(NRN)的杰出和富有成效的成员。塔夫茨在协作性多中心临床研究方面有着悠久的领导历史，最近完成的支持试验中，NRN在登记(55%)和随访(97%)方面的最高记录之一就是例证。塔夫茨吸引了种族和地理上多样化的新生儿人口，他们在波士顿最大的III级托儿所之一接受护理。每年约有600名婴儿(70%为新生儿)进入其41个床位的NICU。此外，新生儿医学和母婴医学方案都与地区医院建立了良好的联系，导致每年有19,000名新生儿的集水区进行转诊。首席研究员Ivan D.Frantz III博士和新生医学部的教职员工已经表明，他们拥有设计、实施和积极参与临床试验的组织力量和研究经验。我们的应用程序通过一种创新的概念应用程序得到增强，该应用程序结合了一种非侵入性基因组方法，通过分析唾液RNA来解释类似胎龄和环境暴露的新生儿临床变异的潜在机制。塔夫茨计划在进行临床研究、数据管理和安全监测方面拥有广泛的机构支持和出色的资源。此外，塔夫茨大学的临床转化科学研究所(CTSI)和塔夫茨医学中心的母婴研究所最近的发展提供了基础设施和更多的合作。