NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 8826788
• 负责人: CHRISTIANE E DAMMANN
• 金额: $ 0.78万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8826788
• 关键词: Admission activity; Area; Beds; Birth; Boston; Caring; Catchment Area; Childhood; Clinical; Clinical Investigator; Clinical Research; Clinical Services; Clinical Trials; Collaborations; Databases; Development; Discipline of obstetrics; Doctor of Philosophy; Enrollment; Environmental Exposure; Expenditure; Faculty; Genomic approach; Genomics; Gestational Age; Goals; Gynecology; Health; Health Services Research; Hospitals; Individual; Infant; Institutes; Instruction; Judgment; Leadership; Massachusetts; Medical; Medical center; Medicine; Monitor; Morbidity - disease rate; Mothers; Multicenter Neonatal Research Network; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care Units; Newborn Infant; Nurseries; Ophthalmology; Patients; Pediatric Hospitals; Pediatric Surgical Procedures; Perinatal; Population; Principal Investigator; Productivity; Protocols documentation; RNA; Recording of previous events; Records; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Proposals; Resources; Safety; Salivary; Science; Site; Societies; Source; System; Testing; Translational Research; Universities; burden of illness; computerized; data management; design; experience; fetal medicine; flexibility; follow-up; high risk infant; improved; innovation; member; mortality; novel strategies; patient population; programs; research study; success

DESCRIPTION (provided by applicant): This competing renewal application aims to demonstrate that the Floating Hospital for Children at Tufts Medical Center has the patient population, faculty and staff expertise, clinical services, research resources, and enrollment and follow-up successes to continue as an outstanding and productive member of the NICHD's Neonatal Research Network (NRN). Tufts has a long history of leadership in collaborative multicenter clinical research studies, as exemplified by one of the highest track records in the NRN for both enrollment (55%) and follow-up (97%) in the recently completed SUPPORT trial. Tufts draws upon an ethnically and geographically diverse neonatal population that receives its care in one of the largest level III nurseries in Boston. Approximately 600 infants (70% inborn) are admitted annually to its 41-bed NICU. In addition, both the Newborn Medicine and Maternal-Fetal Medicine programs have well-established affiliations with regional hospitals that result in referrals from a catchment area of 19,000 annual births. The Principal Investigator, Dr. Ivan D. Frantz III, and the Division of Newborn Medicine's faculty, have shown that they have the organizational strengths and research experience to design, implement, and actively participate in clinical trials. Our application is enhanced by an innovative concept application that incorporates a noninvasive genomic approach to explain the mechanisms underlying clinical variability in newborn infants of similar gestational ages and environmental exposures through analysis of salivary RNA. The Tufts program has broad institutional support and outstanding resources for the conduct of clinical research, data management and safety monitoring. Furthermore, the recent development of a Clinical Translational Science Institute (CTSI) at Tufts University and a Mother Infant Research Institute at Tufts Medical Center provide both infrastructure and additional collaborations.

描述（由申请人提供）：此竞争性更新申请旨在证明塔夫茨医疗中心的儿童浮动医院拥有患者群体、教职员工的专业知识、临床服务、研究资源以及注册和后续成功，可以继续作为 NICHD 新生儿研究网络 (NRN) 的杰出和富有成效的成员。塔夫茨大学在协作多中心临床研究方面拥有悠久的领导地位，最近完成的 SUPPORT 试验是 NRN 中入组率 (55%) 和随访率 (97%) 最高的记录之一。塔夫茨大学拥有种族和地域多样化的新生儿群体，他们在波士顿最大的三级托儿所之一接受护理。每年约有 600 名婴儿（70% 是出生婴儿）入住其 41 个床位的新生儿重症监护病房 (NICU)。此外，新生儿医学和母胎医学项目都与地区医院建立了良好的联系，每年有 19,000 名新生儿从该地区转诊。首席研究员 Ivan D. Frantz III 博士和新生儿医学部的教员表明，他们拥有设计、实施和积极参与临床试验的组织优势和研究经验。我们的应用通过创新概念应用得到增强，该应用结合了非侵入性基因组方法，通过分析唾液 RNA 来解释相似胎龄和环境暴露的新生儿临床变异的机制。塔夫茨大学项目拥有广泛的机构支持和出色的资源，可用于临床研究、数据管理和安全监测。此外，塔夫茨大学临床转化科学研究所 (CTSI) 和塔夫茨医学中心母婴研究所最近的发展提供了基础设施和额外的合作。