A Novel Risk Factor for Cardiovascular Disease: The Insomnia-Short Sleep Phenotyp
A Novel Risk Factor for Cardiovascular Disease: The Insomnia-Short Sleep Phenotyp
批准号:
8633831
负责人:
Christopher Edward Kline
金额:
$13.29万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-01-01 至 2018-12-31
关键词:
AccountingAddressAdultAffectAreaArousalAttenuatedBedsBehavior TherapyBehavioralCardiovascular DiseasesCardiovascular systemClinicalCognitive TherapyCombined Modality TherapyDataDevelopmentDiagnosisDiagnostic and Statistical Manual of Mental DisordersDietDisease MarkerElectroencephalographyEpidemiologic StudiesEpidemiologyExerciseExhibitsFoundationsFrequenciesGoalsHigh PrevalenceHydrocortisoneHypertensionInsulin ResistanceK-Series Research Career ProgramsLinkMeasurementMeasuresMediatingMental DepressionMetabolicMorbidity - disease rateMyocardial InfarctionNeurosecretory SystemsObstructive Sleep ApneaParticipantPhenotypePhysiologicalPopulationPrognostic MarkerRandomized Controlled TrialsResearchResearch PersonnelRiskRisk FactorsRoleSafetySamplingSeveritiesSleepSleep Apnea SyndromesSleep DisordersSleep disturbancesSleeplessnessTestingTimeTrainingTreatment EfficacyWorkbrachial arterycardiovascular disorder riskcareerclinically relevantdesignexperienceheart rate variabilityimprovedindexinginsulin sensitivitymeetingsmortalitynovelpopulation basedprimary outcomepublic health relevancesecondary outcomeurinary
中文摘要
描述(由申请人提供):心血管疾病(CVD)是世界上发病率和死亡率的主要原因,越来越多的证据表明,睡眠障碍-约三分之一的成年人长期经历-可能是一个突出的风险因素。到目前为止,大多数研究都集中在睡眠呼吸障碍的心血管后果上,尽管有令人信服的流行病学证据表明失眠,特别是睡眠时间短的失眠,可能与心血管疾病风险增加有关。对于这种睡眠表型的CVD风险增加的鉴定将具有显著意义。
英文摘要
DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the world's leading cause of morbidity and mortality, and evidence is mounting that sleep disturbance-which is chronically experienced by approximately one-third of the adult population-may be a prominent risk factor. The majority of research thus far has focused on the cardiovascular consequences of sleep disordered breathing, though there is compelling epidemiologic evidence that insomnia, particularly insomnia with short sleep duration, may be associated with increased CVD risk. Identification of increased CVD risk for this sleep phenotype would have significant
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