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A Novel Risk Factor for Cardiovascular Disease: The Insomnia-Short Sleep Phenotyp

心血管疾病的新危险因素：失眠-睡眠不足表型

基本信息

批准号：
9197927
负责人：
Christopher Edward Kline
金额：
$ 17.06万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9197927
关键词：
Address Adult Affect Area Arousal Attenuated Beds Behavior Therapy Behavioral Cardiovascular Diseases Cardiovascular system Chronic Clinical Cognitive Therapy Combined Modality Therapy DSM-V Data Development Diagnosis Diet Disease Marker Electroencephalography Epidemiology Exercise Exhibits Foundations Frequencies Functional disorder Goals High Prevalence Hydrocortisone Hypertension Insulin Resistance K-Series Research Career Programs Link Measurement Measures Mediating Mental Depression Metabolic Morbidity - disease rate Myocardial Infarction Neurosecretory Systems Obstructive Sleep Apnea Participant Phenotype Physiological Population Prognostic Marker Randomized Controlled Trials Research Research Personnel Risk Risk Factors Role Sampling Severities Sleep Sleep Apnea Syndromes Sleep Disorders Sleep disturbances Sleeplessness Smoking Testing Time Training Treatment Efficacy Work behavioral study brachial artery cardiovascular disorder risk cardiovascular risk factor career clinically relevant design epidemiology study exercise training experience heart rate variability improved indexing insulin sensitivity mortality novel physical inactivity population based primary outcome public health relevance safety and feasibility secondary outcome urinary

项目摘要

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the world's leading cause of morbidity and mortality, and evidence is mounting that sleep disturbance-which is chronically experienced by approximately one-third of the adult population-may be a prominent risk factor. The majority of research thus far has focused on the cardiovascular consequences of sleep disordered breathing, though there is compelling epidemiologic evidence that insomnia, particularly insomnia with short sleep duration, may be associated with increased CVD risk. Identification of increased CVD risk for this sleep phenotype would have significant

描述（由申请人提供）：心血管疾病（CVD）是世界上发病率和死亡率的主要原因，越来越多的证据表明，睡眠障碍-约三分之一的成年人长期经历-可能是一个突出的风险因素。到目前为止，大多数研究都集中在睡眠呼吸障碍的心血管后果上，尽管有令人信服的流行病学证据表明失眠，特别是睡眠时间短的失眠，可能与心血管疾病风险增加有关。对于这种睡眠表型的CVD风险增加的鉴定将具有显著意义。